(22 nodes) Inclusion body network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD12138	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (482 aa)
	DsimGD12632	GD12632. (152 aa)
	DsimGD13960	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (462 aa)
	DsimGD25593	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (731 aa)
	DsimGD17732	GD17732. (290 aa)
	DsimGD24651	GD24651. (197 aa)
	DsimGD21515	GD21515. (59 aa)
	DsimGD13409	GD13409. (206 aa)
	DsimGD22467	GD22467. (465 aa)
	ref(2)P	Refractory to sigma P. (599 aa)
	DsimGD25005	GD25005. (531 aa)
	DsimGD10819	GD10819. (76 aa)
	DsimGD25609	GD25609; Belongs to the protein kinase superfamily. (294 aa)
	DsimGD16479	GD16479. (92 aa)
	HDAC6	HDAC6. (777 aa)
	DsimGD18067	GD18067. (100 aa)
	DsimGD18068	GD18068. (513 aa)
	DsimGD19118	T-complex protein 1 subunit gamma. (544 aa)
	DsimGD18186	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (509 aa)
	DsimGD14885	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (527 aa)
	DsimGD14365	GD14365. (292 aa)
	DsimGD13318	GD13318. (323 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD12138	DsimGD13318	B4QJN9	B4QPY5	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	GD13318.	0.601
DsimGD12138	DsimGD14885	B4QJN9	B4QRZ4	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.582
DsimGD12138	DsimGD18068	B4QJN9	B4QY24	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	GD18068.	0.570
DsimGD12138	DsimGD25005	B4QJN9	B4QB08	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	GD25005.	0.637
DsimGD12138	DsimGD25609	B4QJN9	B4QGW7	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	GD25609; Belongs to the protein kinase superfamily.	0.452
DsimGD12138	HDAC6	B4QJN9	B4R564	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	HDAC6.	0.625
DsimGD12138	ref(2)P	B4QJN9	B4QA06	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Refractory to sigma P.	0.914
DsimGD13318	DsimGD12138	B4QPY5	B4QJN9	GD13318.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.601
DsimGD13960	DsimGD19118	B4QJE8	B4QWG0	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	T-complex protein 1 subunit gamma.	0.546
DsimGD14885	DsimGD12138	B4QRZ4	B4QJN9	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.582
DsimGD14885	DsimGD18067	B4QRZ4	B4QY25	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD18067.	0.704
DsimGD14885	DsimGD18068	B4QRZ4	B4QY24	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD18068.	0.805
DsimGD14885	DsimGD25005	B4QRZ4	B4QB08	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD25005.	0.594
DsimGD14885	DsimGD25609	B4QRZ4	B4QGW7	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD25609; Belongs to the protein kinase superfamily.	0.666
DsimGD14885	HDAC6	B4QRZ4	B4R564	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	HDAC6.	0.541
DsimGD18067	DsimGD14885	B4QY25	B4QRZ4	GD18067.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.704
DsimGD18067	DsimGD25005	B4QY25	B4QB08	GD18067.	GD25005.	0.702
DsimGD18067	DsimGD25609	B4QY25	B4QGW7	GD18067.	GD25609; Belongs to the protein kinase superfamily.	0.848
DsimGD18067	HDAC6	B4QY25	B4R564	GD18067.	HDAC6.	0.627
DsimGD18068	DsimGD12138	B4QY24	B4QJN9	GD18068.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.570