(180 nodes) Zinc finger, RING/FYVE/PHD-type network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD15170	GD15170. (241 aa)
	dor	Deep orange. (986 aa)
	DsimGD24619	GD24619. (151 aa)
	DsimGD24575	GD24575. (320 aa)
	DsimGD24519	GD24519. (564 aa)
	DsimGD24472	Inhibitor of growth protein. (288 aa)
	DsimGD24862	GD24862. (484 aa)
	DsimGD24872	GD24872. (211 aa)
	DsimGD24366	GD24366. (255 aa)
	DsimGD22698	GD22698. (164 aa)
	DsimGD24275	GD24275. (267 aa)
	DsimGD23368	GD23368. (689 aa)
	DsimGD22616	GD22616. (1091 aa)
	DsimGD22092	GD22092. (1210 aa)
	DsimGD22576	GD22576. (433 aa)
	DsimGD22064	Inhibitor of growth protein. (253 aa)
	DsimGD23424	GD23424. (993 aa)
	DsimGD22545	GD22545. (91 aa)
	DsimGD22543	GD22543. (570 aa)
	DsimGD22050	GD22050. (332 aa)
	DsimGD23509	GD23509. (505 aa)
	DsimGD23513	GD23513. (919 aa)
	DsimGD23049	GD23049. (186 aa)
	DsimGD24047	GD24047. (176 aa)
	DsimGD22391	GD22391. (85 aa)
	DsimGD20205	GD20205. (2270 aa)
	DsimGD20672	GD20672. (96 aa)
	DsimGD18753	GD18753. (813 aa)
	DsimGD19234	GD19234. (112 aa)
	DsimGD20128	GD20128. (542 aa)
	DsimGD21606	GD21606. (205 aa)
	DsimGD21603	GD21603. (626 aa)
	DsimGD21594	GD21594. (1662 aa)
	DsimGD20581	GD20581. (1169 aa)
	DsimGD16392	GD16392. (635 aa)
	DsimGD18324	GD18324. (651 aa)
	DsimGD19361	GD19361. (1140 aa)
	DsimGD12263	GD12263. (501 aa)
	DsimGD12268	GD12268. (2208 aa)
	DsimGD12272	GD12272. (1737 aa)
	Chd3	GD14801. (893 aa)
	DsimGD14320	GD14320. (429 aa)
	DsimGD13798	GD13798. (338 aa)
	DsimGD13307	GD13307. (163 aa)
	DsimGD12329	GD12329. (259 aa)
	DsimGD12336	Ubiquitin carboxyl-terminal hydrolase. (496 aa)
	DsimGD14237	RBR-type E3 ubiquitin transferase. (341 aa)
	DsimGD13355	Ubiquitin carboxyl-terminal hydrolase. (826 aa)
	DsimGD13360	GD13360. (284 aa)
	qjt	GD14711. (233 aa)
	DsimGD13376	GD13376. (642 aa)
	DsimGD13395	GD13395. (984 aa)
	DsimGD14672	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (321 aa)
	DsimGD14671	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (384 aa)
	DsimGD12929	GD12929. (206 aa)
	DsimGD12443	GD12443. (601 aa)
	DsimGD14649	GD14649. (222 aa)
	DsimGD13459	GD13459. (247 aa)
	DsimGD13625	GD13625. (299 aa)
	DsimGD13467	GD13467. (708 aa)
	DsimGD12476	GD12476. (651 aa)
	DsimGD14094	GD14094. (596 aa)
	DsimGD12518	GD12518. (430 aa)
	DsimGD12522	GD12522. (1169 aa)
	DsimGD14579	GD14579. (314 aa)
	DsimGD14082	GD14082. (285 aa)
	DsimGD15058	General transcription factor IIH subunit. (438 aa)
	DsimGD13033	GD13033. (393 aa)
	DsimGD13529	GD13529. (1963 aa)
	DsimGD13535	GD13535. (980 aa)
	DsimGD25390	GD25390. (74 aa)
	DsimGD11347	GD11347. (435 aa)
	DsimGD11346	GD11346. (263 aa)
	DsimGD10828	GD10828. (1128 aa)
	DsimGD11873	GD11873. (867 aa)
	DsimGD11340	GD11340. (1041 aa)
	DsimGD11336	GD11336. (1137 aa)
	DsimGD25438	GD25438. (1815 aa)
	DsimGD25891	GD25891. (113 aa)
	DsimGD25895	GD25895. (2944 aa)
	DsimGD11835	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1225 aa)
	DsimGD11292	GD11292. (839 aa)
	DsimGD11289	GD11289. (2160 aa)
	DsimGD11808	GD11808. (718 aa)
	DsimGD25960	RBR-type E3 ubiquitin transferase. (1119 aa)
	DsimGD25961	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (334 aa)
	DsimGD24252	GD24252. (883 aa)
	DsimGD22709	GD22709. (1183 aa)
	DsimGD23279	GD23279. (483 aa)
	DsimGD21743	GD21743. (447 aa)
	DsimGD24174	GD24174. (1080 aa)
	DsimGD23716	GD23716. (342 aa)
	CHIP	CHIP. (289 aa)
	DsimGD23699	GD23699. (408 aa)
	DsimGD22259	GD22259. (519 aa)
	DsimGD23693	GD23693. (1053 aa)
	DsimGD23216	GD23216. (541 aa)
	DsimGD23202	GD23202. (346 aa)
	DsimGD23189	GD23189. (562 aa)
	DsimGD23175	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (759 aa)
	DsimGD24108	GD24108. (404 aa)
	DsimGD24069	GD24069. (1318 aa)
	DsimGD12110	GD12110. (386 aa)
	DsimGD12138	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (482 aa)
	DsimGD14471	GD14471. (1941 aa)
	DsimGD13124	GD13124. (1229 aa)
	DsimGD13945	GD13945. (1270 aa)
	DsimGD25052	GD25052. (761 aa)
	DsimGD25510	GD25510. (607 aa)
	DsimGD25123	GD25123. (704 aa)
	DsimGD11654	RBR-type E3 ubiquitin transferase. (509 aa)
	DsimGD25587	GD25587. (498 aa)
	DsimGD10632	GD10632. (601 aa)
	DsimGD11597	Zinc finger FYVE domain-containing protein. (1345 aa)
	DsimGD25226	GD25226. (646 aa)
	DsimGD25254	GD25254. (421 aa)
	DsimGD11014	GD11014. (122 aa)
	DsimGD10992	GD10992. (374 aa)
	DsimGD21906	GD21906. (155 aa)
	DsimGD10496	GD10496. (881 aa)
	DsimGD25747	GD25747. (101 aa)
	DsimGD25767	GD25767. (114 aa)
	DsimGD25796	GD25796. (324 aa)
	DsimGD11426	GD11426. (1047 aa)
	DsimGD11423	GD11423. (868 aa)
	DsimGD25803	GD25803. (700 aa)
	DsimGD15571	GD15571. (770 aa)
	DsimGD16520	GD16520. (108 aa)
	DsimGD16050	GD16050. (2427 aa)
	DsimGD16069	GD16069. (794 aa)
	DsimGD17393	GD17393. (675 aa)
	DsimGD16805	GD16805. (273 aa)
	DsimGD16802	GD16802. (734 aa)
	DsimGD16794	GD16794. (80 aa)
	DsimGD15775	GD15775. (277 aa)
	DsimGD15792	GD15792. (232 aa)
	HDAC6	HDAC6. (777 aa)
	DsimGD16731	Ubiquitinyl hydrolase 1. (882 aa)
	DsimGD16331	GD16331. (388 aa)
	Dsim_GD16617	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (627 aa)
	DsimGD16615	GD16615. (316 aa)
	DsimGD16408	GD16408. (1076 aa)
	DsimGD24410	GD24410. (627 aa)
	DsimGD24408	GD24408. (543 aa)
	DsimGD24381	GD24381. (549 aa)
	DsimGD24403	GD24403. (147 aa)
	DsimGD18381	GD18381. (104 aa)
	DsimGD18889	GD18889. (240 aa)
	DsimGD17101	GD17101. (322 aa)
	DsimGD18432	GD18432. (397 aa)
	DsimGD17753	GD17753. (462 aa)
	DsimGD18468	GD18468. (299 aa)
	DsimGD20397	GD20397. (212 aa)
	DsimGD20379	GD20379. (1332 aa)
	DsimGD19503	GD19503. (329 aa)
	DsimGD19873	GD19873. (537 aa)
	DsimGD18047	GD18047. (567 aa)
	DsimGD18048	GD18048. (219 aa)
	DsimGD18065	GD18065. (436 aa)
	DsimGD19827	GD19827. (329 aa)
	DsimGD18085	GD18085. (493 aa)
	DsimGD18091	GD18091. (820 aa)
	DsimGD18588	GD18588. (379 aa)
	DsimGD20824	GD20824. (671 aa)
	DsimGD18594	GD18594. (816 aa)
	DsimGD24897	GD24897. (510 aa)
	DsimGD19604	GD19604. (2135 aa)
	DsimGD21308	GD21308. (330 aa)
	DsimGD20788	GD20788. (877 aa)
	DsimGD20739	GD20739. (381 aa)
	DsimGD19682	GD19682. (382 aa)
	DsimGD21226	GD21226. (678 aa)
	DsimGD20212	Inhibitor of growth protein. (433 aa)
	DsimGD19337	CG4973 protein. (356 aa)
	DsimGD15310	GD15310. (913 aa)
	DsimGD15350	GD15350. (326 aa)
	DsimGD15224	GD15224. (240 aa)
	DsimGD17597	E3 ubiquitin protein ligase. (1044 aa)
	DsimGD15105	GD15105. (451 aa)
	DsimGD15475	GD15475. (683 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHIP	DsimGD12138	B4Q9A7	B4QJN9	CHIP.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.726
CHIP	DsimGD12522	B4Q9A7	B4QLS7	CHIP.	GD12522.	0.400
CHIP	DsimGD17101	B4Q9A7	B4R1L8	CHIP.	GD17101.	0.605
CHIP	DsimGD22092	B4Q9A7	B4Q4B0	CHIP.	GD22092.	0.617
CHIP	DsimGD23424	B4Q9A7	B4Q4Z7	CHIP.	GD23424.	0.483
CHIP	DsimGD24174	B4Q9A7	B4Q9E8	CHIP.	GD24174.	0.400
Chd3	DsimGD16050	B4QQG0	B4R761	GD14801.	GD16050.	0.406
Chd3	DsimGD20212	B4QQG0	B4QV40	GD14801.	Inhibitor of growth protein.	0.460
Chd3	DsimGD20581	B4QQG0	B4QSY1	GD14801.	GD20581.	0.913
Chd3	HDAC6	B4QQG0	B4R564	GD14801.	HDAC6.	0.923
DsimGD10632	DsimGD11014	B4QGS2	B4QEZ8	GD10632.	GD11014.	0.551
DsimGD10632	DsimGD13033	B4QGS2	B4QKX8	GD10632.	GD13033.	0.695
DsimGD10632	DsimGD13625	B4QGS2	B4QMG3	GD10632.	GD13625.	0.436
DsimGD10632	DsimGD15792	B4QGS2	B4R591	GD10632.	GD15792.	0.601
DsimGD10632	DsimGD16520	B4QGS2	B4R7G5	GD10632.	GD16520.	0.551
DsimGD10632	DsimGD18047	B4QGS2	B4QY57	GD10632.	GD18047.	0.532
DsimGD10632	DsimGD19827	B4QGS2	B4QXL1	GD10632.	GD19827.	0.695
DsimGD10632	qjt	B4QGS2	B4QNV8	GD10632.	GD14711.	0.799
DsimGD10828	DsimGD13529	B4QC55	B4QKV1	GD10828.	GD13529.	0.426
DsimGD10828	DsimGD16050	B4QC55	B4R761	GD10828.	GD16050.	0.401