STRINGSTRING
DsimGD14249 DsimGD14249 His4 His4 DsimGD15662 DsimGD15662 DsimGD16141 DsimGD16141 DsimGD21470 DsimGD21470 DsimGD19497 DsimGD19497 DsimGD20884 DsimGD20884 DsimGD20882 DsimGD20882 DsimGD18194 DsimGD18194 DsimGD18195 DsimGD18195 WRNexo WRNexo DsimGD20659 DsimGD20659 DsimGD14810 DsimGD14810 DsimGD14808 DsimGD14808 DsimGD14791 DsimGD14791 DsimGD13291 DsimGD13291 DsimGD13015 DsimGD13015 DsimGD12597 DsimGD12597 DsimGD25225 DsimGD25225 DsimGD11503 DsimGD11503 DsimGD10909 DsimGD10909 DsimGD10829 DsimGD10829 DsimGD10828 DsimGD10828 DsimGD11839 DsimGD11839 DsimGD25957 DsimGD25957 DsimGD22189 DsimGD22189 DsimGD22190 DsimGD22190 DsimGD22729 DsimGD22729 DsimGD22755 DsimGD22755 DsimGD23698 DsimGD23698 DsimGD21967 DsimGD21967 DsimGD23411 DsimGD23411 DsimGD22597 DsimGD22597 DsimGD21638 DsimGD21638 DsimGD24311 DsimGD24311 DsimGD14701 DsimGD14701 DsimGD13834 DsimGD13834 DsimGD24561 DsimGD24561
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DsimGD14249GD14249. (142 aa)
His4Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
DsimGD15662GD15662. (208 aa)
DsimGD16141GD16141. (486 aa)
DsimGD21470GD21470. (1976 aa)
DsimGD19497GD19497. (604 aa)
DsimGD20884GD20884. (268 aa)
DsimGD20882Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
DsimGD18194GD18194. (1098 aa)
DsimGD18195GD18195. (212 aa)
WRNexoWerner Syndrome-like exonuclease; Essential for the formation of DNA replication focal centers. Has an important role in maintaining genome stability. Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction (By similarity); Belongs to the WRNexo family. (354 aa)
DsimGD20659GD20659. (541 aa)
DsimGD14810GD14810. (648 aa)
DsimGD14808GD14808. (424 aa)
DsimGD14791RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (481 aa)
DsimGD13291GD13291. (331 aa)
DsimGD13015GD13015. (659 aa)
DsimGD12597GD12597. (178 aa)
DsimGD25225H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (240 aa)
DsimGD11503GD11503. (303 aa)
DsimGD10909GD10909. (1001 aa)
DsimGD10829GD10829. (417 aa)
DsimGD10828GD10828. (1128 aa)
DsimGD11839GD11839. (508 aa)
DsimGD25957GD25957. (64 aa)
DsimGD22189GD22189. (227 aa)
DsimGD22190GD22190. (128 aa)
DsimGD22729GD22729. (978 aa)
DsimGD22755ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (663 aa)
DsimGD23698GD23698. (332 aa)
DsimGD21967GD21967. (433 aa)
DsimGD23411GD23411. (1507 aa)
DsimGD22597GD22597. (466 aa)
DsimGD21638Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (74 aa)
DsimGD24311GD24311; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1267 aa)
DsimGD14701GD14701; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (65 aa)
DsimGD13834GD13834. (230 aa)
DsimGD24561GD24561. (285 aa)
Your Current Organism:
Drosophila simulans
NCBI taxonomy Id: 7240
Other names: D. simulans
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