(141 nodes) RAC1 GTPase cycle network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD22724	GD22724. (931 aa)
	DsimGD23746	GD23746. (332 aa)
	DsimGD11248	GD11248. (956 aa)
	DsimGD25964	GD25964. (695 aa)
	DsimGD24253	GD24253. (1134 aa)
	DsimGD15401	GD15401. (635 aa)
	DsimGD15403	GD15403. (499 aa)
	DsimGD17672	GD17672. (306 aa)
	DsimGD17610	GD17610. (213 aa)
	DsimGD17605	GD17605. (494 aa)
	DsimGD11924	GD11924. (134 aa)
	DsimGD15478	GD15478. (226 aa)
	DsimGD24498	GD24498. (275 aa)
	DsimGD24847	GD24847. (239 aa)
	DsimGD24441	GD24441. (116 aa)
	DsimGD18487	GD18487. (85 aa)
	DsimGD23783	GD23783. (888 aa)
	DsimGD24279	GD24279. (1090 aa)
	DsimGD23367	GD23367. (118 aa)
	DsimGD23870	GD23870. (344 aa)
	DsimGD22551	GD22551. (478 aa)
	Sos	Sos. (1595 aa)
	DsimGD22022	GD22022. (1358 aa)
	DsimGD22999	GD22999; Belongs to the DOCK family. (2064 aa)
	DsimGD22490	GD22490; Belongs to the DOCK family. (2202 aa)
	DsimGD21979	GD21979. (312 aa)
	DsimGD21980	GD21980. (346 aa)
	DsimGD23016	GD23016. (496 aa)
	DsimGD22964	GD22964. (450 aa)
	DsimGD24014	GD24014. (1021 aa)
	DsimGD22353	GD22353. (129 aa)
	DsimGD22352	GD22352. (594 aa)
	DsimGD21769	GD21769. (546 aa)
	DsimGD23745	GD23745. (260 aa)
	DsimGD21752	GD21752. (722 aa)
	DsimGD21733	GD21733. (1842 aa)
	DsimGD21753	GD21753. (503 aa)
	DsimGD17456	GD17456. (191 aa)
	DsimGD17441	GD17441. (104 aa)
	DsimGD17440	GD17440. (523 aa)
	DsimGD15601	GD15601. (784 aa)
	DsimGD15602	GD15602. (532 aa)
	RhoGAP1A	RhoGAP1A. (1221 aa)
	DsimGD17385	GD17385. (760 aa)
	DsimGD17354	GD17354. (1731 aa)
	DsimGD17349	GD17349. (1117 aa)
	DsimGD16887	GD16887. (512 aa)
	DsimGD16886	GD16886. (496 aa)
	DsimGD15678	GD15678. (351 aa)
	DsimGD17335	GD17335. (398 aa)
	DsimGD16875	Integrin beta; Belongs to the integrin beta chain family. (838 aa)
	DsimGD17324	GD17324. (314 aa)
	DsimGD17288	GD17288. (404 aa)
	DsimGD16254	GD16254. (495 aa)
	DsimGD15533	GD15533. (1804 aa)
	DsimGD24409	GD24409. (971 aa)
	DsimGD21040	GD21040; Belongs to the DOCK family. (1466 aa)
	DsimGD21039	GD21039. (484 aa)
	DsimGD19391	GD19391. (625 aa)
	DsimGD18910	GD18910. (1044 aa)
	DsimGD20009	GD20009. (1168 aa)
	DsimGD20968	GD20968. (668 aa)
	DsimGD20455	GD20455. (473 aa)
	DsimGD20423	GD20423. (1017 aa)
	DsimGD19928	GD19928. (362 aa)
	DsimGD18994	GD18994. (804 aa)
	DsimGD21384	GD21384; Belongs to the DOCK family. (2149 aa)
	DsimGD19013	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1243 aa)
	DsimGD19869	Non-specific serine/threonine protein kinase. (701 aa)
	DsimGD19574	GD19574. (765 aa)
	DsimGD18079	GD18079. (939 aa)
	DsimGD18089	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1388 aa)
	DsimGD20287	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (405 aa)
	DsimGD20779	GD20779. (373 aa)
	DsimGD19636	GD19636. (198 aa)
	DsimGD19756	GD19756. (601 aa)
	DsimGD19755	GD19755. (2680 aa)
	DsimGD19754	GD19754. (406 aa)
	DsimGD20766	GD20766. (939 aa)
	DsimGD19719	GD19719. (225 aa)
	DsimGD18728	GD18728. (572 aa)
	DsimGD19262	GD19262. (306 aa)
	DsimGD19266	GD19266. (210 aa)
	DsimGD21608	GD21608. (1826 aa)
	DsimGD19322	GD19322. (731 aa)
	DsimGD18324	GD18324. (651 aa)
	DsimGD21052	GD21052. (90 aa)
	DsimGD12711	Non-specific serine/threonine protein kinase. (1854 aa)
	DsimGD13896	GD13896. (2022 aa)
	DsimGD12229	GD12229. (180 aa)
	DsimGD14840	GD14840. (201 aa)
	DsimGD14362	GD14362. (57 aa)
	DsimGD14361	GD14361. (287 aa)
	DsimGD13848	GD13848. (265 aa)
	DsimGD12282	GD12282. (154 aa)
	DsimGD13812	GD13812. (711 aa)
	DsimGD14289	GD14289. (1071 aa)
	DsimGD14683	GD14683. (1028 aa)
	DsimGD14195	GD14195. (288 aa)
	DsimGD14193	GD14193. (296 aa)
	DsimGD13412	GD13412. (203 aa)
	DsimGD12452	GD12452. (1421 aa)
	DsimGD12485	GD12485. (185 aa)
	DsimGD14623	GD14623. (157 aa)
	DsimGD12495	GD12495. (185 aa)
	DsimGD14611	GD14611. (116 aa)
	DsimGD13487	GD13487. (192 aa)
	DsimGD13598	GD13598. (249 aa)
	DsimGD13500	GD13500. (706 aa)
	DsimGD13501	GD13501. (812 aa)
	DsimGD14560	GD14560. (291 aa)
	DsimGD14559	GD14559. (567 aa)
	DsimGD13031	GD13031. (1374 aa)
	DsimGD14028	GD14028. (1311 aa)
	Hem	Hem. (1126 aa)
	DsimGD12097	GD12097. (1486 aa)
	DsimGD14478	GD14478. (1277 aa)
	DsimGD11240	GD11240. (2562 aa)
	DsimGD25998	GD25998. (152 aa)
	DsimGD25075	GD25075. (1068 aa)
	DsimGD10089	Non-specific serine/threonine protein kinase. (1888 aa)
	DsimGD25144	GD25144. (862 aa)
	DsimGD11618	GD11618. (341 aa)
	DsimGD11101	GD11101. (491 aa)
	DsimGD11011	GD11011. (1064 aa)
	DsimGD11009	GD11009. (899 aa)
	DsimGD25736	GD25736. (625 aa)
	DsimGD11515	GD11515. (447 aa)
	DsimGD11514	GD11514. (774 aa)
	DsimGD10404	Phospholipase. (1364 aa)
	DsimGD11922	GD11922. (305 aa)
	DsimGD25385	GD25385. (932 aa)
	DsimGD25400	GD25400. (424 aa)
	DsimGD10359	GD10359. (318 aa)
	DsimGD11326	GD11326. (196 aa)
	DsimGD24972	GD24972; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1188 aa)
	DsimGD17870	GD17870. (35 aa)
	DsimGD11822	GD11822. (650 aa)
	DsimGD25448	GD25448. (405 aa)
	DsimGD25940	GD25940; Belongs to the MAGUK family. (377 aa)
	DsimGD11249	GD11249. (508 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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same PNG format, but at higher resolution

... as a vector graphic:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10089	DsimGD12711	B4QH71	B4QRN5	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.884
DsimGD10089	DsimGD13487	B4QH71	B4QLZ5	Non-specific serine/threonine protein kinase.	GD13487.	0.794
DsimGD10089	DsimGD14361	B4QH71	B4QR62	Non-specific serine/threonine protein kinase.	GD14361.	0.427
DsimGD10089	DsimGD14362	B4QH71	B4QR63	Non-specific serine/threonine protein kinase.	GD14362.	0.427
DsimGD10089	DsimGD17456	B4QH71	B4R7S5	Non-specific serine/threonine protein kinase.	GD17456.	0.696
DsimGD10089	DsimGD24279	B4QH71	B4Q3H5	Non-specific serine/threonine protein kinase.	GD24279.	0.483
DsimGD10089	DsimGD24972	B4QH71	B4QBJ0	Non-specific serine/threonine protein kinase.	GD24972; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.427
DsimGD10089	RhoGAP1A	B4QH71	B4R720	Non-specific serine/threonine protein kinase.	RhoGAP1A.	0.453
DsimGD10359	DsimGD12711	B4QC39	B4QRN5	GD10359.	Non-specific serine/threonine protein kinase.	0.408
DsimGD10359	DsimGD13500	B4QC39	B4QLH7	GD10359.	GD13500.	0.766
DsimGD10359	DsimGD13501	B4QC39	B4QLH6	GD10359.	GD13501.	0.409
DsimGD10359	DsimGD17349	B4QC39	B4R6L8	GD10359.	GD17349.	0.442
DsimGD10359	DsimGD19574	B4QC39	B4QXM1	GD10359.	GD19574.	0.583
DsimGD10359	DsimGD21733	B4QC39	B4QA30	GD10359.	GD21733.	0.582
DsimGD10359	DsimGD21752	B4QC39	B4Q9Z5	GD10359.	GD21752.	0.625
DsimGD10359	DsimGD21753	B4QC39	B4Q9Z4	GD10359.	GD21753.	0.625
DsimGD10359	DsimGD21979	B4QC39	B4Q5X8	GD10359.	GD21979.	0.509
DsimGD10359	DsimGD21980	B4QC39	B4Q5Y0	GD10359.	GD21980.	0.509
DsimGD10359	DsimGD25448	B4QC39	B4QBC6	GD10359.	GD25448.	0.583
DsimGD10404	DsimGD11101	B4QD83	B4QGE1	Phospholipase.	GD11101.	0.482