(19 nodes) Nicotinate and nicotinamide metabolism network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD11991	GD11991. (666 aa)
	DsimGD23867	GD23867. (826 aa)
	DsimGD10747	GD10747. (790 aa)
	DsimGD11273	GD11273; Belongs to the 5'-nucleotidase family. (599 aa)
	DsimGD11274	GD11274; Belongs to the 5'-nucleotidase family. (585 aa)
	DsimGD11275	GD11275; Belongs to the 5'-nucleotidase family. (579 aa)
	DsimGD25021	GD25021. (339 aa)
	DsimGD25753	GD25753. (519 aa)
	DsimGD25750	GD25750. (57 aa)
	DsimGD10107	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (413 aa)
	DsimGD13387	GD13387. (396 aa)
	DsimGD19348	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (386 aa)
	DsimGD21151	Nicotinamide-nucleotide adenylyltransferase. (297 aa)
	DsimGD20725	GD20725. (333 aa)
	DsimGD21410	GD21410. (81 aa)
	DsimGD17001	GD17001. (190 aa)
	DsimGD15878	GD15878. (1059 aa)
	DsimGD16246	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (312 aa)
	DsimGD15638	GD15638. (403 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10107	DsimGD15878	B4QGR4	B4R4E5	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	GD15878.	0.940
DsimGD10107	DsimGD16246	B4QGR4	B4R505	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.900
DsimGD10107	DsimGD19348	B4QGR4	B4QS45	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.900
DsimGD10107	DsimGD20725	B4QGR4	B4QV96	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	GD20725.	0.900
DsimGD10107	DsimGD21151	B4QGR4	B4QU80	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide-nucleotide adenylyltransferase.	0.928
DsimGD10107	DsimGD21410	B4QGR4	B4QZG0	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	GD21410.	0.900
DsimGD10107	DsimGD23867	B4QGR4	B4Q4C2	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	GD23867.	0.900
DsimGD10107	DsimGD25750	B4QGR4	B4QEF6	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	GD25750.	0.929
DsimGD10107	DsimGD25753	B4QGR4	B4QEF3	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	GD25753.	0.983
DsimGD10747	DsimGD11273	B4QAL5	B4QAU6	GD10747.	GD11273; Belongs to the 5'-nucleotidase family.	0.932
DsimGD10747	DsimGD11274	B4QAL5	B4QAU8	GD10747.	GD11274; Belongs to the 5'-nucleotidase family.	0.931
DsimGD10747	DsimGD11275	B4QAL5	B4QAU9	GD10747.	GD11275; Belongs to the 5'-nucleotidase family.	0.937
DsimGD10747	DsimGD11991	B4QAL5	B4NRW0	GD10747.	GD11991.	0.910
DsimGD10747	DsimGD13387	B4QAL5	B4QNJ1	GD10747.	GD13387.	0.944
DsimGD10747	DsimGD15638	B4QAL5	B4R6Z2	GD10747.	GD15638.	0.902
DsimGD10747	DsimGD15878	B4QAL5	B4R4E5	GD10747.	GD15878.	0.505
DsimGD10747	DsimGD17001	B4QAL5	B4R2R1	GD10747.	GD17001.	0.925
DsimGD10747	DsimGD21151	B4QAL5	B4QU80	GD10747.	Nicotinamide-nucleotide adenylyltransferase.	0.935
DsimGD10747	DsimGD25021	B4QAL5	B4QAY1	GD10747.	GD25021.	0.944
DsimGD11273	DsimGD10747	B4QAU6	B4QAL5	GD11273; Belongs to the 5'-nucleotidase family.	GD10747.	0.932