(71 nodes) Toll and Imd signaling pathway network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD17149	Bendless; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	DsimGD15385	GD15385. (289 aa)
	DsimGD15111	GD15111. (295 aa)
	DsimGD15186	CLIP domain-containing serine protease; Belongs to the peptidase S1 family. CLIP subfamily. (419 aa)
	DsimGD24678	GD24678. (345 aa)
	lic	Licorne. (334 aa)
	DsimGD24476	GD24476; Belongs to the peptidase S1 family. (199 aa)
	DsimGD23919	Mitogen-activated protein kinase. (365 aa)
	DsimGD21999	GD21999; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	cact	Cact. (479 aa)
	Dif	Dif. (662 aa)
	dl	Dl, isoform A. (679 aa)
	DsimGD22800	GD22800. (1466 aa)
	DsimGD22289	Mitogen-activated protein kinase. (372 aa)
	DsimGD11363	GD11363. (45 aa)
	DsimGD11365	GD11365. (45 aa)
	DsimGD11366	GD11366. (39 aa)
	imd	Imd. (273 aa)
	key	Key. (440 aa)
	DsimGD11905	GD11905. (381 aa)
	DsimGD11417	Diptericin A2. (84 aa)
	DsimGD11418	GD11418. (124 aa)
	DsimGD11419	GD11419. (120 aa)
	DsimGD11443	GD11443. (832 aa)
	DsimGD25246	GD25246. (42 aa)
	DsimGD10589	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (185 aa)
	DsimPGRP-SC1a	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (185 aa)
	DsimGD25179	GD25179. (199 aa)
	DsimGD25587	GD25587. (498 aa)
	DsimGD10085	GD10085. (537 aa)
	DsimGD25573	GD25573. (695 aa)
	DsimGD13054	GD13054. (243 aa)
	PGRP-SD	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (186 aa)
	DsimGD13039	GD13039. (1346 aa)
	DsimGD14138	GD14138. (490 aa)
	PGRP-LA	PGRP-LA, isoform A. (368 aa)
	DsimGD14166	GD14166. (500 aa)
	DsimGD14168	GD14168. (337 aa)
	PGRP-SB2	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (182 aa)
	PGRP-SB1	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (190 aa)
	dro2	Drosomycin-2. (89 aa)
	dro5	Drosomycin-5. (69 aa)
	dro1	Drosomycin-1. (69 aa)
	GNBP1	GNBP1. (492 aa)
	DsimGD13202	GD13202. (145 aa)
	DsimGD18319	Mitogen-activated protein kinase. (347 aa)
	DsimGD18318	Mitogen-activated protein kinase. (366 aa)
	DsimGD20154	GD20154. (1621 aa)
	DsimGD20271	GD20271; Belongs to the peptidase S1 family. (738 aa)
	Tl	Toll; Belongs to the Toll-like receptor family. (1096 aa)
	Rel	Rel. (972 aa)
	spz	Spz. (350 aa)
	ird5	Ird5. (733 aa)
	DsimGD20917	GD20917. (239 aa)
	DsimGD20402	GD20402; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	DsimGD21462	GD21462. (212 aa)
	DsimGD18431	GD18431; Belongs to the protein kinase superfamily. (190 aa)
	DsimGD20006	GD20006. (510 aa)
	CecA1	CecA1. (63 aa)
	DsimGD20035	GD20035; Belongs to the protein kinase superfamily. (393 aa)
	DsimGD21025	CLIP domain-containing serine protease; Belongs to the peptidase S1 family. CLIP subfamily. (400 aa)
	PGRP-SA	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (202 aa)
	Dredd	Dredd. (183 aa)
	CecB	Cecropin-B; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family. (63 aa)
	CecC	Cecropin-C; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family. (63 aa)
	dro3	Dro3 protein. (71 aa)
	Drs	Drs protein. (70 aa)
	dro4	Dro4 protein. (71 aa)
	dro6	Dro6 protein. (72 aa)
	PGRP-SC2	Peptidoglycan-recognition protein SC2; N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity). Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (184 aa)
	Def	Defensin. (92 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CecA1	CecB	B4R1K2	P67792	CecA1.	Cecropin-B; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family.	0.900
CecA1	CecC	B4R1K2	P84021	CecA1.	Cecropin-C; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family.	0.900
CecA1	Def	B4R1K2	Q86BW0	CecA1.	Defensin.	0.802
CecA1	Dif	B4R1K2	B4Q7X7	CecA1.	Dif.	0.968
CecA1	DsimGD11417	B4R1K2	B4QDJ7	CecA1.	Diptericin A2.	0.820
CecA1	DsimGD11418	B4R1K2	B4QDJ8	CecA1.	GD11418.	0.754
CecA1	DsimGD11419	B4R1K2	B4QDJ9	CecA1.	GD11419.	0.754
CecA1	DsimGD14166	B4R1K2	B4QMR5	CecA1.	GD14166.	0.698
CecA1	DsimGD15111	B4R1K2	B4NTA1	CecA1.	GD15111.	0.589
CecA1	DsimGD24678	B4R1K2	B4NTM3	CecA1.	GD24678.	0.610
CecA1	DsimGD25179	B4R1K2	B4QGI3	CecA1.	GD25179.	0.522
CecA1	PGRP-SA	B4R1K2	B4R346	CecA1.	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.	0.573
CecA1	PGRP-SD	B4R1K2	B4QKW5	CecA1.	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.	0.614
CecA1	Rel	B4R1K2	B4QXA6	CecA1.	Rel.	0.971
CecA1	dl	B4R1K2	B4Q7Y0	CecA1.	Dl, isoform A.	0.906
CecA1	dro2	B4R1K2	B4QPH0	CecA1.	Drosomycin-2.	0.572
CecA1	imd	B4R1K2	B4QCF0	CecA1.	Imd.	0.800
CecA1	spz	B4R1K2	B4QXD7	CecA1.	Spz.	0.506
CecB	CecA1	P67792	B4R1K2	Cecropin-B; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family.	CecA1.	0.900
CecB	CecC	P67792	P84021	Cecropin-B; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family.	Cecropin-C; Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria; Belongs to the cecropin family.	0.989