(42 nodes) Neuron remodeling network (Drosophila virilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DvirGJ16389	Uncharacterized protein. (499 aa)
	DvirGJ18738	Uncharacterized protein, isoform U. (1952 aa)
	DvirGJ23329	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (665 aa)
	DvirGJ12529	Uncharacterized protein, isoform A. (1051 aa)
	DvirGJ11811	Uncharacterized protein. (1718 aa)
	DvirGJ12339	Uncharacterized protein. (409 aa)
	DvirGJ13743	Uncharacterized protein. (774 aa)
	DvirGJ13250	Uncharacterized protein; Belongs to the peptidase C2 family. (918 aa)
	DvirGJ13253	Uncharacterized protein; Belongs to the peptidase C14A family. (445 aa)
	DvirGJ12080	Chromo domain-containing protein. (381 aa)
	DvirGJ20887	Uncharacterized protein, isoform A. (851 aa)
	DvirGJ20835	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1230 aa)
	DvirGJ20232	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (210 aa)
	DvirGJ22346	Uncharacterized protein; Belongs to the peptidase C14A family. (314 aa)
	DvirGJ22348	Phosphatidylinositol 3-kinase catalytic subunit type 3. (943 aa)
	DvirGJ20462	Uncharacterized protein; Belongs to the peptidase C2 family. (821 aa)
	DvirGJ21897	Uncharacterized protein, isoform A. (506 aa)
	DvirGJ13343	Uncharacterized protein. (725 aa)
	DvirGJ12548	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DvirGJ21335	SCD domain-containing protein. (1129 aa)
	DvirGJ20786	Uncharacterized protein. (721 aa)
	DvirGJ19552	Uncharacterized protein; Belongs to the peptidase C14A family. (271 aa)
	DvirGJ17250	Uncharacterized protein. (5521 aa)
	DvirGJ17377	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (734 aa)
	DvirGJ23418	Uncharacterized protein; Belongs to the peptidase C14A family. (300 aa)
	DvirGJ22988	Protein kinase domain-containing protein. (722 aa)
	DvirGJ22971	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	DvirGJ24312	Uncharacterized protein, isoform A. (1364 aa)
	DvirGJ22902	Uncharacterized protein. (4783 aa)
	DvirGJ23355	Ubiquitin carboxyl-terminal hydrolase. (906 aa)
	DvirGJ24096	Uncharacterized protein; Belongs to the peptidase C14A family. (345 aa)
	DvirGJ19444	Uncharacterized protein; Belongs to the peptidase C2 family. (666 aa)
	DvirGJ18657	Uncharacterized protein, isoform A. (650 aa)
	DvirGJ10720	Uncharacterized protein. (663 aa)
	DvirGJ16581	Uncharacterized protein; Belongs to the AAA ATPase family. (442 aa)
	DvirGJ18055	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2504 aa)
	DvirGJ17965	Uncharacterized protein. (712 aa)
	DvirGJ14197	Structural maintenance of chromosomes protein. (1240 aa)
	DvirGJ14539	Uncharacterized protein. (422 aa)
	DvirGJ18577	Uncharacterized protein. (228 aa)
	DvirGJ15034	Uncharacterized protein, isoform A. (536 aa)
	DvirGJ14974	Uncharacterized protein. (577 aa)

Your Current Organism:

Drosophila virilis

NCBI taxonomy Id: 7244
Other names: D. virilis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DvirGJ11811	DvirGJ12339	B4LDN0	B4LE79	Uncharacterized protein.	Uncharacterized protein.	0.712
DvirGJ11811	DvirGJ16581	B4LDN0	B4M6S6	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.578
DvirGJ11811	DvirGJ17377	B4LDN0	B4LUT9	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.679
DvirGJ11811	DvirGJ18577	B4LDN0	B4ME56	Uncharacterized protein.	Uncharacterized protein.	0.996
DvirGJ11811	DvirGJ20232	B4LDN0	B4LJL4	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.510
DvirGJ11811	DvirGJ20786	B4LDN0	B4LS62	Uncharacterized protein.	Uncharacterized protein.	0.938
DvirGJ11811	DvirGJ23355	B4LDN0	B4LYC8	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.441
DvirGJ12080	DvirGJ13343	B4LH19	B4LQE4	Chromo domain-containing protein.	Uncharacterized protein.	0.582
DvirGJ12339	DvirGJ11811	B4LE79	B4LDN0	Uncharacterized protein.	Uncharacterized protein.	0.712
DvirGJ12339	DvirGJ16581	B4LE79	B4M6S6	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.750
DvirGJ12339	DvirGJ17377	B4LE79	B4LUT9	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.979
DvirGJ12339	DvirGJ18577	B4LE79	B4ME56	Uncharacterized protein.	Uncharacterized protein.	0.893
DvirGJ12339	DvirGJ20232	B4LE79	B4LJL4	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.999
DvirGJ12339	DvirGJ20786	B4LE79	B4LS62	Uncharacterized protein.	Uncharacterized protein.	0.955
DvirGJ12529	DvirGJ15034	B4LC88	B4MFH3	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.777
DvirGJ13250	DvirGJ18577	B4LGL7	B4ME56	Uncharacterized protein; Belongs to the peptidase C2 family.	Uncharacterized protein.	0.403
DvirGJ13253	DvirGJ22971	B4LGM4	B4LW93	Uncharacterized protein; Belongs to the peptidase C14A family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.412
DvirGJ13343	DvirGJ12080	B4LQE4	B4LH19	Uncharacterized protein.	Chromo domain-containing protein.	0.582
DvirGJ13343	DvirGJ14197	B4LQE4	B4MBZ5	Uncharacterized protein.	Structural maintenance of chromosomes protein.	0.999
DvirGJ13343	DvirGJ21335	B4LQE4	B4LRG7	Uncharacterized protein.	SCD domain-containing protein.	0.981