(16 nodes) CD28 dependent PI3K/Akt signaling, and TSC1-TSC2 complex network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK27487	Uncharacterized protein. (952 aa)
	DwilGK27587	Raptor_N domain-containing protein. (1479 aa)
	DwilGK17534	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
	DwilGK16938	Rap-GAP domain-containing protein. (1845 aa)
	DwilGK21478	GK21478. (591 aa)
	DwilGK15310	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2447 aa)
	DwilGK21025	Protein kinase domain-containing protein. (886 aa)
	DwilGK16256	Uncharacterized protein. (1921 aa)
	DwilGK11157	Uncharacterized protein. (1132 aa)
	DwilGK25774	Non-specific serine/threonine protein kinase. (919 aa)
	DwilGK25539	WD_REPEATS_REGION domain-containing protein. (311 aa)
	DwilGK22414	Uncharacterized protein. (182 aa)
	DwilGK14255	Rab-GAP TBC domain-containing protein. (248 aa)
	DwilGK13262	Non-specific serine/threonine protein kinase. (531 aa)
	DwilGK13260	Non-specific serine/threonine protein kinase. (674 aa)
	DwilGK22939	Uncharacterized protein. (547 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK11157	DwilGK13260	B4NBN0	B4NL10	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.980
DwilGK11157	DwilGK13262	B4NBN0	B4NL09	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.980
DwilGK11157	DwilGK14255	B4NBN0	B4NHU4	Uncharacterized protein.	Rab-GAP TBC domain-containing protein.	0.999
DwilGK11157	DwilGK15310	B4NBN0	B4MUG4	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.938
DwilGK11157	DwilGK16256	B4NBN0	B4N1P6	Uncharacterized protein.	Uncharacterized protein.	0.539
DwilGK11157	DwilGK16938	B4NBN0	B4MKW7	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.999
DwilGK11157	DwilGK17534	B4NBN0	A0A0Q9X1F0	Uncharacterized protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.707
DwilGK11157	DwilGK21478	B4NBN0	B4MQ71	Uncharacterized protein.	GK21478.	0.472
DwilGK11157	DwilGK22414	B4NBN0	B4NG51	Uncharacterized protein.	Uncharacterized protein.	0.999
DwilGK11157	DwilGK22939	B4NBN0	B4NN82	Uncharacterized protein.	Uncharacterized protein.	0.550
DwilGK11157	DwilGK25539	B4NBN0	B4NDY4	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.782
DwilGK11157	DwilGK25774	B4NBN0	B4NC19	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.924
DwilGK11157	DwilGK27487	B4NBN0	A0A0Q9WRZ8	Uncharacterized protein.	Uncharacterized protein.	0.414
DwilGK11157	DwilGK27587	B4NBN0	A0A0Q9WW79	Uncharacterized protein.	Raptor_N domain-containing protein.	0.858
DwilGK13260	DwilGK11157	B4NL10	B4NBN0	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.980
DwilGK13260	DwilGK13262	B4NL10	B4NL09	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.900
DwilGK13260	DwilGK14255	B4NL10	B4NHU4	Non-specific serine/threonine protein kinase.	Rab-GAP TBC domain-containing protein.	0.930
DwilGK13260	DwilGK15310	B4NL10	B4MUG4	Non-specific serine/threonine protein kinase.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.980
DwilGK13260	DwilGK16256	B4NL10	B4N1P6	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.858
DwilGK13260	DwilGK16938	B4NL10	B4MKW7	Non-specific serine/threonine protein kinase.	Rap-GAP domain-containing protein.	0.977