(13 nodes) cAMP metabolic process, and 35-cyclic nucleotide phosphodiesterase, conserved site network (Drosophila willistoni)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK10356	Phosphodiesterase. (1089 aa)
	DwilGK16713	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1079 aa)
	DwilGK15719	Uncharacterized protein. (383 aa)
	DwilGK20007	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1726 aa)
	DwilGK14971	Phosphodiesterase. (836 aa)
	DwilGK15554	Uncharacterized protein. (1124 aa)
	DwilGK24656	Phosphodiesterase. (1456 aa)
	DwilGK24141	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1182 aa)
	DwilGK12535	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1158 aa)
	DwilGK12673	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1720 aa)
	Pde6	cGMP-specific 3',5'-cyclic phosphodiesterase; Has a role regulating cGMP transport in Malpighian tubule principal cells. (1127 aa)
	DwilGK23066	Uncharacterized protein; Belongs to the cyclic nucleotide phosphodiesterase family. (960 aa)
	DwilGK18424	Uncharacterized protein, isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (2214 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10356	DwilGK12535	A0A0Q9WZA2	B4N305	Phosphodiesterase.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.919
DwilGK10356	DwilGK12673	A0A0Q9WZA2	B4N3B2	Phosphodiesterase.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.919
DwilGK10356	DwilGK14971	A0A0Q9WZA2	B4MVY8	Phosphodiesterase.	Phosphodiesterase.	0.555
DwilGK10356	DwilGK15554	A0A0Q9WZA2	B4MWX8	Phosphodiesterase.	Uncharacterized protein.	0.919
DwilGK10356	DwilGK16713	A0A0Q9WZA2	B4MMI7	Phosphodiesterase.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.919
DwilGK10356	DwilGK18424	A0A0Q9WZA2	B4NPP7	Phosphodiesterase.	Uncharacterized protein, isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.946
DwilGK10356	DwilGK20007	A0A0Q9WZA2	B4MSP0	Phosphodiesterase.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.929
DwilGK10356	DwilGK23066	A0A0Q9WZA2	B4NMM0	Phosphodiesterase.	Uncharacterized protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.952
DwilGK10356	DwilGK24141	A0A0Q9WZA2	B4N130	Phosphodiesterase.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.919
DwilGK12535	DwilGK10356	B4N305	A0A0Q9WZA2	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.919
DwilGK12535	DwilGK14971	B4N305	B4MVY8	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.911
DwilGK12535	DwilGK15554	B4N305	B4MWX8	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.905
DwilGK12535	DwilGK15719	B4N305	B4MRN1	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.653
DwilGK12535	DwilGK20007	B4N305	B4MSP0	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.510
DwilGK12535	DwilGK23066	B4N305	B4NMM0	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.905
DwilGK12535	DwilGK24656	B4N305	B4MZG4	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.919
DwilGK12535	Pde6	B4N305	B4NAL6	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cGMP-specific 3',5'-cyclic phosphodiesterase; Has a role regulating cGMP transport in Malpighian tubule principal cells.	0.717
DwilGK12673	DwilGK10356	B4N3B2	A0A0Q9WZA2	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.919
DwilGK12673	DwilGK14971	B4N3B2	B4MVY8	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.911
DwilGK12673	DwilGK15719	B4N3B2	B4MRN1	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.630