(27 nodes) Negative regulation of autophagy network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK24988	Mothers against decapentaplegic homolog. (490 aa)
	DwilGK20470	Uncharacterized protein. (614 aa)
	DwilGK24277	TGF_BETA_2 domain-containing protein. (592 aa)
	DwilGK16281	Uncharacterized protein, isoform A; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
	DwilGK16461	DUF4206 domain-containing protein. (814 aa)
	DwilGK12345	Myotubularin phosphatase domain-containing protein. (623 aa)
	DwilGK18692	Plug_translocon domain-containing protein. (476 aa)
	DwilGK11959	FK506-binding protein. (358 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	DwilGK11389	Uncharacterized protein. (4031 aa)
	DwilGK25150	Uncharacterized protein. (774 aa)
	DwilGK25784	Uncharacterized protein. (219 aa)
	DwilGK25826	Uncharacterized protein. (392 aa)
	DwilGK15144	Uncharacterized protein. (894 aa)
	DwilGK25612	WW domain-containing protein. (968 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK22414	Uncharacterized protein. (182 aa)
	DwilGK14416	UBIQUITIN_CONJUGAT_2 domain-containing protein. (4901 aa)
	DwilGK17989	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (431 aa)
	DwilGK23361	Protein kinase domain-containing protein. (163 aa)
	DwilGK16998	Uncharacterized protein; Belongs to the BI1 family. (244 aa)
	Usp36	Ubiquitin carboxyl-terminal hydrolase 36; Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins; Belongs to the peptidase C19 family. (1311 aa)
	DwilGK19628	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (100 aa)
	DwilGK19452	Uncharacterized protein. (96 aa)
	DwilGK21742	GK21742; Belongs to the WD repeat SEC13 family. (356 aa)
	DwilGK15310	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2447 aa)
	DwilGK14712	Lipid_DES domain-containing protein; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (321 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK11389	DwilGK14416	B4NAF9	B4NJP6	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.407
DwilGK11959	DwilGK15310	B4N7Z0	B4MUG4	FK506-binding protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.415
DwilGK12078	DwilGK14416	B4N8K5	B4NJP6	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.536
DwilGK12078	DwilGK15310	B4N8K5	B4MUG4	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.468
DwilGK12078	DwilGK22414	B4N8K5	B4NG51	Uncharacterized protein.	Uncharacterized protein.	0.456
DwilGK12078	DwilGK22711	B4N8K5	B4NFV1	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.958
DwilGK14416	DwilGK11389	B4NJP6	B4NAF9	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.407
DwilGK14416	DwilGK12078	B4NJP6	B4N8K5	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.536
DwilGK14416	DwilGK15310	B4NJP6	B4MUG4	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.440
DwilGK14416	DwilGK17989	B4NJP6	A0A0Q9X2Q0	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.536
DwilGK14416	DwilGK21742	B4NJP6	B4MPP5	UBIQUITIN_CONJUGAT_2 domain-containing protein.	GK21742; Belongs to the WD repeat SEC13 family.	0.647
DwilGK14416	DwilGK23361	B4NJP6	A0A0Q9X6S0	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Protein kinase domain-containing protein.	0.536
DwilGK14416	DwilGK25150	B4NJP6	B4NC38	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.536
DwilGK15144	DwilGK15310	B4MVU7	B4MUG4	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.544
DwilGK15144	DwilGK20470	B4MVU7	B4MXT1	Uncharacterized protein.	Uncharacterized protein.	0.987
DwilGK15144	DwilGK21742	B4MVU7	B4MPP5	Uncharacterized protein.	GK21742; Belongs to the WD repeat SEC13 family.	0.999
DwilGK15144	DwilGK22414	B4MVU7	B4NG51	Uncharacterized protein.	Uncharacterized protein.	0.634
DwilGK15144	DwilGK25826	B4MVU7	B4NCB0	Uncharacterized protein.	Uncharacterized protein.	0.999
DwilGK15310	DwilGK11959	B4MUG4	B4N7Z0	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	FK506-binding protein.	0.415
DwilGK15310	DwilGK12078	B4MUG4	B4N8K5	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.468