(50 nodes) Regulation of epithelial cell migration network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK12114	Uncharacterized protein. (651 aa)
	DwilGK11109	Uncharacterized protein, isoform B; Belongs to the DOCK family. (2012 aa)
	DwilGK21732	GK21732. (1310 aa)
	DwilGK17694	Uncharacterized protein. (174 aa)
	DwilGK22865	J domain-containing protein. (2430 aa)
	DwilGK23286	VIR_N domain-containing protein. (1884 aa)
	DwilGK22947	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1505 aa)
	DwilGK23082	HDAC_interact domain-containing protein. (2138 aa)
	DwilGK10547	WD_REPEATS_REGION domain-containing protein. (436 aa)
	DwilGK18440	Uncharacterized protein. (711 aa)
	DwilGK13260	Non-specific serine/threonine protein kinase. (674 aa)
	DwilGK13262	Non-specific serine/threonine protein kinase. (531 aa)
	DwilGK14377	Uncharacterized protein. (502 aa)
	DwilGK13501	Uncharacterized protein. (512 aa)
	DwilGK12444	Mitogen-activated protein kinase. (371 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK25249	Protein kinase domain-containing protein. (1146 aa)
	DwilGK25059	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1281 aa)
	kay	Transcription factor kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra (By similarity). (620 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	DwilGK23971	RING-type domain-containing protein. (457 aa)
	DwilGK18041	Uncharacterized protein. (930 aa)
	DwilGK17892	ORC_WH_C domain-containing protein. (717 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK12652	Uncharacterized protein. (1592 aa)
	DwilGK12579	Uncharacterized protein, isoform A. (576 aa)
	DwilGK16524	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (329 aa)
	DwilGK16116	Uncharacterized protein. (1845 aa)
	DwilGK24165	Uncharacterized protein. (441 aa)
	DwilGK24576	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (768 aa)
	DwilGK24503	Uncharacterized protein. (1202 aa)
	DwilGK24781	Uncharacterized protein. (422 aa)
	DwilGK24272	COesterase domain-containing protein. (962 aa)
	DwilGK22090	BZIP domain-containing protein. (456 aa)
	DwilGK13061	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (972 aa)
	DwilGK15519	Uncharacterized protein. (720 aa)
	DwilGK14947	Uncharacterized protein. (1551 aa)
	DwilGK15139	Uncharacterized protein. (760 aa)
	DwilGK15071	Uncharacterized protein. (2090 aa)
	DwilGK23859	Receptor protein-tyrosine kinase. (1496 aa)
	DwilGK19766	Uncharacterized protein, isoform C. (1472 aa)
	DwilGK15874	Non-specific serine/threonine protein kinase. (1150 aa)
	DwilGK21906	GK21906. (321 aa)
	DwilGK21847	GK21847. (1406 aa)
	DwilGK19542	Uncharacterized protein. (2185 aa)
	DwilGK17606	Protein kinase domain-containing protein. (1144 aa)
	Dwilvn	Vein. (481 aa)
	DwilGK10766	Receptor protein-tyrosine kinase. (1386 aa)
	DwilGK27491	Uncharacterized protein. (177 aa)
	DwilGK18181	Uncharacterized protein, isoform B. (5914 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10766	DwilGK12078	B4MJ19	B4N8K5	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.426
DwilGK10766	DwilGK13061	B4MJ19	B4MXA6	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.	0.586
DwilGK10766	DwilGK13260	B4MJ19	B4NL10	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase.	0.435
DwilGK10766	DwilGK13262	B4MJ19	B4NL09	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase.	0.432
DwilGK10766	DwilGK15519	B4MJ19	B4MWQ6	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.586
DwilGK10766	DwilGK16524	B4MJ19	B4N2K6	Receptor protein-tyrosine kinase.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.534
DwilGK10766	DwilGK18041	B4MJ19	B4N6E0	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.999
DwilGK10766	DwilGK18440	B4MJ19	B4NLN4	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.694
DwilGK10766	DwilGK20502	B4MJ19	B4N547	Receptor protein-tyrosine kinase.	GK20502.	0.542
DwilGK10766	DwilGK22711	B4MJ19	B4NFV1	Receptor protein-tyrosine kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.837
DwilGK10766	DwilGK22947	B4MJ19	B4NN66	Receptor protein-tyrosine kinase.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.590
DwilGK10766	DwilGK23859	B4MJ19	B4MTK0	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.739
DwilGK10766	DwilGK24576	B4MJ19	B4N0G4	Receptor protein-tyrosine kinase.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.822
DwilGK10766	DwilGK25059	B4MJ19	B4NCL7	Receptor protein-tyrosine kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.934
DwilGK10766	Dwilvn	B4MJ19	B4MMK9	Receptor protein-tyrosine kinase.	Vein.	0.975
DwilGK11109	DwilGK20502	A0A0Q9WTI9	B4N547	Uncharacterized protein, isoform B; Belongs to the DOCK family.	GK20502.	0.812
DwilGK12078	DwilGK10766	B4N8K5	B4MJ19	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.426
DwilGK12078	DwilGK18041	B4N8K5	B4N6E0	Uncharacterized protein.	Uncharacterized protein.	0.944
DwilGK12078	DwilGK22711	B4N8K5	B4NFV1	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.958
DwilGK12114	DwilGK22947	A0A0Q9WTQ4	B4NN66	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.601