(88 nodes) Signal release network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK24963	Uncharacterized protein; Belongs to the synaptobrevin family. (211 aa)
	DwilGK25575	Uncharacterized protein. (3257 aa)
	DwilGK25278	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1681 aa)
	DwilGK22630	Uncharacterized protein. (1041 aa)
	DwilGK14159	Uncharacterized protein. (457 aa)
	DwilGK14186	WD_REPEATS_REGION domain-containing protein. (459 aa)
	DwilGK14515	GOLD domain-containing protein. (209 aa)
	DwilGK18341	Uncharacterized protein. (745 aa)
	DwilGK13183	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	DwilGK12803	PH domain-containing protein. (685 aa)
	DwilGK13863	Sec8_exocyst domain-containing protein. (991 aa)
	DwilGK14379	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	bai	Transmembrane emp24 domain-containing protein bai; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected (By similarity); Belongs to the EMP24/GP25L family. (206 aa)
	DwilGK12908	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (195 aa)
	DwilGK12948	Uncharacterized protein. (859 aa)
	DwilGK13680	Uncharacterized protein. (415 aa)
	DwilGK13058	Uncharacterized protein. (750 aa)
	DwilGK11144	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (213 aa)
	DwilGK27970	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (291 aa)
	DwilGK28066	Uncharacterized protein. (167 aa)
	DwilGK27403	Uncharacterized protein. (1426 aa)
	DwilGK13659	Uncharacterized protein. (3205 aa)
	DwilGK13625	MHD1 domain-containing protein. (628 aa)
	DwilGK12005	Uncharacterized protein. (490 aa)
	DwilGK27107	PH domain-containing protein. (152 aa)
	DwilGK13019	Uncharacterized protein, isoform B; Belongs to the MAGUK family. (928 aa)
	DwilGK27345	Uncharacterized protein. (87 aa)
	DwilGK21153	Uncharacterized protein. (204 aa)
	DwilGK10340	Uncharacterized protein, isoform B. (656 aa)
	DwilGK10259	MSP domain-containing protein. (265 aa)
	DwilGK20891	Uncharacterized protein, isoform A; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	DwilGK20954	t-SNARE coiled-coil homology domain-containing protein. (338 aa)
	DwilGK16673	Uncharacterized protein. (1430 aa)
	DwilGK16949	Uncharacterized protein. (292 aa)
	DwilGK17413	Uncharacterized protein, isoform A. (594 aa)
	DwilGK17426	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (290 aa)
	DwilGK17427	SynN domain-containing protein. (213 aa)
	DwilGK17463	Uncharacterized protein. (1665 aa)
	DwilGK17108	Uncharacterized protein, isoform C. (248 aa)
	DwilGK19661	Uncharacterized protein. (220 aa)
	DwilGK19680	Uncharacterized protein, isoform A. (1021 aa)
	DwilGK21716	GK21716. (170 aa)
	DwilGK21818	GK21818. (288 aa)
	DwilGK21820	GK21820. (312 aa)
	DwilGK21821	GK21821. (1148 aa)
	DwilGK21930	GK21930. (300 aa)
	DwilGK21967	GK21967. (738 aa)
	DwilGK15806	t-SNARE coiled-coil homology domain-containing protein. (286 aa)
	DwilGK15875	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (512 aa)
	DwilObp56h	Odorant-binding protein 56h. (137 aa)
	DwilGK19999	Uncharacterized protein. (187 aa)
	DwilGK20001	Uncharacterized protein. (187 aa)
	DwilGK20006	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (537 aa)
	DwilGK20009	Secretory carrier-associated membrane protein. (347 aa)
	DwilGK20022	UBP-type domain-containing protein. (1187 aa)
	DwilGK19732	GOLD domain-containing protein. (224 aa)
	DwilGK19716	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (353 aa)
	DwilGK23817	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (894 aa)
	DwilGK11384	t-SNARE coiled-coil homology domain-containing protein. (239 aa)
	DwilGK18165	Uncharacterized protein. (495 aa)
	DwilGK18145	Uncharacterized protein, isoform A. (474 aa)
	DwilGK24481	SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. (136 aa)
	DwilGK24240	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa)
	DwilGK16189	UDENN domain-containing protein. (2040 aa)
	DwilGK12542	Uncharacterized protein. (1359 aa)
	DwilGK12664	Uncharacterized protein. (370 aa)
	DwilGK11715	t-SNARE coiled-coil homology domain-containing protein. (338 aa)
	DwilGK10424	Uncharacterized protein, isoform A. (1284 aa)
	DwilGK20496	GK20496; Belongs to the small GTPase superfamily. Arf family. (182 aa)
	wls	Protein wntless; A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exos [...] (562 aa)
	DwilGK17938	Synaptogyrin. (239 aa)
	DwilGK18016	Uncharacterized protein, isoform B. (151 aa)
	DwilGK18040	Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (694 aa)
	DwilGK23666	Uncharacterized protein, isoform A. (190 aa)
	DwilGK24495	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
	DwilGK24504	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (652 aa)
	DwilGK21099	Uncharacterized protein. (1348 aa)
	DwilGK11126	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	DwilGK11009	Uncharacterized protein; Belongs to the heat shock protein 70 family. (650 aa)
	DwilGK10950	Uncharacterized protein, isoform D. (143 aa)
	DwilGK11253	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (574 aa)
	DwilGK11837	Uncharacterized protein. (2618 aa)
	DwilGK11158	Uncharacterized protein. (710 aa)
	DwilGK25120	Uncharacterized protein, isoform A; Belongs to the STXBP/unc-18/SEC1 family. (599 aa)
	DwilGK10056	Uncharacterized protein. (170 aa)
	DwilGK10123	GOLD domain-containing protein. (233 aa)
	DwilGK24986	EF-hand domain-containing protein. (1967 aa)
	DwilGK25401	t-SNARE coiled-coil homology domain-containing protein. (324 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10056	DwilGK13019	B4NCK1	A0A0Q9X5S6	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the MAGUK family.	0.823
DwilGK10056	DwilGK21716	B4NCK1	B4MPK4	Uncharacterized protein.	GK21716.	0.932
DwilGK10123	DwilGK14515	B4NCY8	B4NPT9	GOLD domain-containing protein.	GOLD domain-containing protein.	0.948
DwilGK10123	DwilGK16949	B4NCY8	B4MLK9	GOLD domain-containing protein.	Uncharacterized protein.	0.690
DwilGK10123	DwilGK20496	B4NCY8	B4N532	GOLD domain-containing protein.	GK20496; Belongs to the small GTPase superfamily. Arf family.	0.541
DwilGK10123	DwilGK24963	B4NCY8	B4ND73	GOLD domain-containing protein.	Uncharacterized protein; Belongs to the synaptobrevin family.	0.712
DwilGK10123	bai	B4NCY8	B4NIY1	GOLD domain-containing protein.	Transmembrane emp24 domain-containing protein bai; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected (By similarity); Belongs to the EMP24/GP25L family.	0.984
DwilGK10259	DwilGK18016	B4MJC1	B4N687	MSP domain-containing protein.	Uncharacterized protein, isoform B.	0.489
DwilGK10340	DwilGK11126	B4MJ74	B4N800	Uncharacterized protein, isoform B.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.452
DwilGK10340	DwilGK11144	B4MJ74	A0A0Q9WT28	Uncharacterized protein, isoform B.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.452
DwilGK10340	DwilGK19661	B4MJ74	B4MNY2	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.749
DwilGK10950	DwilGK11126	B4N926	B4N800	Uncharacterized protein, isoform D.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.653
DwilGK10950	DwilGK11144	B4N926	A0A0Q9WT28	Uncharacterized protein, isoform D.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.613
DwilGK10950	DwilGK11837	B4N926	B4NB68	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.999
DwilGK10950	DwilGK12542	B4N926	B4N2Z6	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.932
DwilGK10950	DwilGK13019	B4N926	A0A0Q9X5S6	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform B; Belongs to the MAGUK family.	0.917
DwilGK10950	DwilGK13659	B4N926	A0A0Q9WUG5	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.673
DwilGK10950	DwilGK15806	B4N926	B4MRC4	Uncharacterized protein, isoform D.	t-SNARE coiled-coil homology domain-containing protein.	0.594
DwilGK10950	DwilGK17108	B4N926	B4MNC8	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform C.	0.623
DwilGK10950	DwilGK18016	B4N926	B4N687	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform B.	0.767