(63 nodes) Positive regulation of cell migration network (Drosophila willistoni)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK10547	WD_REPEATS_REGION domain-containing protein. (436 aa)
	DwilGK13260	Non-specific serine/threonine protein kinase. (674 aa)
	DwilGK13262	Non-specific serine/threonine protein kinase. (531 aa)
	DwilGK14377	Uncharacterized protein. (502 aa)
	DwilGK13501	Uncharacterized protein. (512 aa)
	DwilGK12444	Mitogen-activated protein kinase. (371 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK25249	Protein kinase domain-containing protein. (1146 aa)
	DwilGK25059	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1281 aa)
	kay	Transcription factor kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra (By similarity). (620 aa)
	DwilGK11836	Fibroblast growth factor receptor. (758 aa)
	DwilGK12252	Uncharacterized protein. (330 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	DwilGK11982	Uncharacterized protein. (503 aa)
	DwilGK18750	Sema domain-containing protein; Belongs to the semaphorin family. (1105 aa)
	DwilGK23971	RING-type domain-containing protein. (457 aa)
	DwilGK12333	EGF-like domain-containing protein. (238 aa)
	DwilGK18041	Uncharacterized protein. (930 aa)
	DwilGK17997	Uncharacterized protein. (1471 aa)
	DwilGK17966	WH1 domain-containing protein. (713 aa)
	DwilGK17883	Uncharacterized protein. (492 aa)
	DwilGK17892	ORC_WH_C domain-containing protein. (717 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK16524	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (329 aa)
	DwilGK16116	Uncharacterized protein. (1845 aa)
	DwilGK24165	Uncharacterized protein. (441 aa)
	DwilGK24576	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (768 aa)
	DwilGK24503	Uncharacterized protein. (1202 aa)
	DwilGK24781	Uncharacterized protein. (422 aa)
	DwilGK24272	COesterase domain-containing protein. (962 aa)
	DwilGK24740	PDGF_2 domain-containing protein. (205 aa)
	DwilGK24738	PDGF_2 domain-containing protein. (252 aa)
	DwilGK22090	BZIP domain-containing protein. (456 aa)
	DwilGK15227	EGF-like domain-containing protein. (252 aa)
	DwilGK14947	Uncharacterized protein. (1551 aa)
	DwilGK15139	Uncharacterized protein. (760 aa)
	DwilGK15071	Uncharacterized protein. (2090 aa)
	DwilGK23859	Receptor protein-tyrosine kinase. (1496 aa)
	DwilGK19766	Uncharacterized protein, isoform C. (1472 aa)
	DwilGK15918	Sema domain-containing protein; Belongs to the semaphorin family. (782 aa)
	DwilGK15874	Non-specific serine/threonine protein kinase. (1150 aa)
	DwilGK22019	GK22019. (2234 aa)
	DwilGK21847	GK21847. (1406 aa)
	DwilGK21702	GK21702; Belongs to the semaphorin family. (721 aa)
	DwilGK21697	GK21697; Belongs to the semaphorin family. (731 aa)
	DwilGK19542	Uncharacterized protein. (2185 aa)
	DwilGK17606	Protein kinase domain-containing protein. (1144 aa)
	Dwilvn	Vein. (481 aa)
	DwilGK16738	Uncharacterized protein. (1787 aa)
	DwilGK17319	UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
	DwilGK17220	Sema domain-containing protein. (1106 aa)
	DwilGK17505	FAM110_C domain-containing protein. (813 aa)
	DwilGK20644	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (435 aa)
	DwilGK10766	Receptor protein-tyrosine kinase. (1386 aa)
	DwilGK10614	Uncharacterized protein. (1072 aa)
	DwilGK27491	Uncharacterized protein. (177 aa)
	DwilGK18181	Uncharacterized protein, isoform B. (5914 aa)
	DwilGK12114	Uncharacterized protein. (651 aa)
	DwilGK11109	Uncharacterized protein, isoform B; Belongs to the DOCK family. (2012 aa)
	DwilGK22947	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1505 aa)
	DwilGK23286	VIR_N domain-containing protein. (1884 aa)
	DwilGK22865	J domain-containing protein. (2430 aa)
	DwilGK17694	Uncharacterized protein. (174 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10614	DwilGK17966	B4MJ18	B4N5Y7	Uncharacterized protein.	WH1 domain-containing protein.	0.422
DwilGK10614	DwilGK19542	B4MJ18	B4MNM8	Uncharacterized protein.	Uncharacterized protein.	0.647
DwilGK10766	DwilGK12078	B4MJ19	B4N8K5	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.426
DwilGK10766	DwilGK12333	B4MJ19	B4N6L0	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.971
DwilGK10766	DwilGK13260	B4MJ19	B4NL10	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase.	0.435
DwilGK10766	DwilGK13262	B4MJ19	B4NL09	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase.	0.432
DwilGK10766	DwilGK15227	B4MJ19	B4MWA8	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.971
DwilGK10766	DwilGK15918	B4MJ19	B4MRZ5	Receptor protein-tyrosine kinase.	Sema domain-containing protein; Belongs to the semaphorin family.	0.446
DwilGK10766	DwilGK16524	B4MJ19	B4N2K6	Receptor protein-tyrosine kinase.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.534
DwilGK10766	DwilGK17220	B4MJ19	B4MLI3	Receptor protein-tyrosine kinase.	Sema domain-containing protein.	0.446
DwilGK10766	DwilGK18041	B4MJ19	B4N6E0	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.999
DwilGK10766	DwilGK18750	B4MJ19	B4N7S2	Receptor protein-tyrosine kinase.	Sema domain-containing protein; Belongs to the semaphorin family.	0.446
DwilGK10766	DwilGK20502	B4MJ19	B4N547	Receptor protein-tyrosine kinase.	GK20502.	0.542
DwilGK10766	DwilGK21697	B4MJ19	B4MPG4	Receptor protein-tyrosine kinase.	GK21697; Belongs to the semaphorin family.	0.446
DwilGK10766	DwilGK21702	B4MJ19	B4MPH4	Receptor protein-tyrosine kinase.	GK21702; Belongs to the semaphorin family.	0.446
DwilGK10766	DwilGK22711	B4MJ19	B4NFV1	Receptor protein-tyrosine kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.837
DwilGK10766	DwilGK22947	B4MJ19	B4NN66	Receptor protein-tyrosine kinase.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.590
DwilGK10766	DwilGK23859	B4MJ19	B4MTK0	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.739
DwilGK10766	DwilGK24576	B4MJ19	B4N0G4	Receptor protein-tyrosine kinase.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.822
DwilGK10766	DwilGK25059	B4MJ19	B4NCL7	Receptor protein-tyrosine kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.934