(29 nodes) Regulation of axon extension network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK16635	BHLH domain-containing protein. (424 aa)
	DwilGK17105	Uncharacterized protein. (534 aa)
	DwilGK21697	GK21697; Belongs to the semaphorin family. (731 aa)
	DwilGK21702	GK21702; Belongs to the semaphorin family. (721 aa)
	DwilGK21945	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (997 aa)
	DwilGK15918	Sema domain-containing protein; Belongs to the semaphorin family. (782 aa)
	DwilGK15407	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DwilGK14661	Uncharacterized protein. (385 aa)
	DwilGK14922	Uncharacterized protein. (1875 aa)
	DwilGK18219	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1709 aa)
	DwilGK24503	Uncharacterized protein. (1202 aa)
	DwilGK24804	Uncharacterized protein. (1226 aa)
	DwilGK16325	Uncharacterized protein. (377 aa)
	DwilGK12696	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (423 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK18750	Sema domain-containing protein; Belongs to the semaphorin family. (1105 aa)
	DwilGK11982	Uncharacterized protein. (503 aa)
	DwilGK10964	Uncharacterized protein, isoform A. (542 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (777 aa)
	DwilGK19483	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family. (3600 aa)
	DwilGK20074	Uncharacterized protein. (1323 aa)
	DwilGK12202	Uncharacterized protein, isoform B. (718 aa)
	DwilGK20892	Uncharacterized protein. (589 aa)
	DwilGK17039	Uncharacterized protein. (1082 aa)
	DwilGK17220	Sema domain-containing protein. (1106 aa)
	DwilGK23247	Uncharacterized protein. (617 aa)
	DwilGK12904	YTH domain-containing protein. (733 aa)
	DwilGK25610	Uncharacterized protein. (626 aa)
	DwilGK17953	Uncharacterized protein, isoform G. (8749 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10964	DwilGK14661	B4N8U3	B4MV91	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.506
DwilGK10964	DwilGK16325	B4N8U3	B4N1K8	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.461
DwilGK10964	spas	B4N8U3	B4NBP4	Uncharacterized protein, isoform A.	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.	0.631
DwilGK12696	DwilGK19483	B4N3F9	A0A0Q9X069	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family.	0.722
DwilGK12696	DwilGK21945	B4N3F9	B4MQU9	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.981
DwilGK12696	DwilGK23247	B4N3F9	B4NN35	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.853
DwilGK12696	DwilGK25610	B4N3F9	B4NEA1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.994
DwilGK14661	DwilGK10964	B4MV91	B4N8U3	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.506
DwilGK14922	DwilGK24804	B4MWA1	B4N176	Uncharacterized protein.	Uncharacterized protein.	0.686
DwilGK15407	DwilGK17105	B4MUZ7	B4MNC3	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.688
DwilGK15407	DwilGK20502	B4MUZ7	B4N547	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	GK20502.	0.518
DwilGK15407	DwilGK25610	B4MUZ7	B4NEA1	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.414
DwilGK16325	DwilGK10964	B4N1K8	B4N8U3	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.461
DwilGK17105	DwilGK15407	B4MNC3	B4MUZ7	Uncharacterized protein.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.688
DwilGK17953	DwilGK20502	A0A0Q9WS80	B4N547	Uncharacterized protein, isoform G.	GK20502.	0.431
DwilGK18750	DwilGK21702	B4N7S2	B4MPH4	Sema domain-containing protein; Belongs to the semaphorin family.	GK21702; Belongs to the semaphorin family.	0.416
DwilGK19483	DwilGK12696	A0A0Q9X069	B4N3F9	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.722
DwilGK19483	DwilGK23247	A0A0Q9X069	B4NN35	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.771
DwilGK19483	DwilGK25610	A0A0Q9X069	B4NEA1	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.709
DwilGK20502	DwilGK15407	B4N547	B4MUZ7	GK20502.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.518