(70 nodes) Cortical cytoskeleton organization network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK15407	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DwilGK14733	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	DwilGK14890	WH2 domain-containing protein. (656 aa)
	DwilGK20025	Uncharacterized protein. (230 aa)
	DwilGK21821	GK21821. (1148 aa)
	DwilGK21820	GK21820. (312 aa)
	DwilGK21818	GK21818. (288 aa)
	DwilGK19661	Uncharacterized protein. (220 aa)
	DwilGK17072	Uncharacterized protein. (1126 aa)
	DwilGK17109	Protein kinase domain-containing protein. (828 aa)
	DwilGK17653	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1646 aa)
	DwilGK16738	Uncharacterized protein. (1787 aa)
	DwilGK17233	Uncharacterized protein. (575 aa)
	DwilGK16960	Uncharacterized protein. (792 aa)
	DwilGK16805	Uncharacterized protein. (192 aa)
	DwilGK17195	Uncharacterized protein. (355 aa)
	DwilGK17037	Uncharacterized protein. (1171 aa)
	DwilGK10641	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
	DwilGK10680	PH domain-containing protein. (1242 aa)
	DwilGK10907	Uncharacterized protein, isoform B. (467 aa)
	DwilGK12150	Uncharacterized protein, isoform B. (2394 aa)
	DwilGK12160	Uncharacterized protein, isoform C. (1874 aa)
	DwilGK26907	Uncharacterized protein. (520 aa)
	DwilGK17798	Uncharacterized protein, isoform B. (354 aa)
	DwilGK17953	Uncharacterized protein, isoform G. (8749 aa)
	DwilGK16737	Uncharacterized protein. (435 aa)
	DwilGK17312	Uncharacterized protein. (191 aa)
	DwilGK23297	Uncharacterized protein. (1719 aa)
	DwilGK23171	PH domain-containing protein. (1493 aa)
	DwilGK23137	Uncharacterized protein. (192 aa)
	DwilGK10551	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (887 aa)
	DwilGK14089	Uncharacterized protein. (736 aa)
	DwilGK12803	PH domain-containing protein. (685 aa)
	DwilGK12817	Elongation of very long chain fatty acids protein. (322 aa)
	DwilGK13863	Sec8_exocyst domain-containing protein. (991 aa)
	DwilGK13835	Uncharacterized protein. (3963 aa)
	DwilGK13484	Uncharacterized protein. (272 aa)
	DwilGK14310	Uncharacterized protein. (2000 aa)
	DwilGK14185	Uncharacterized protein. (214 aa)
	DwilGK22450	Uncharacterized protein. (436 aa)
	DwilGK22329	Uncharacterized protein. (2134 aa)
	DwilGK25713	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1379 aa)
	DwilGK25227	Uncharacterized protein. (637 aa)
	DwilGK25241	Uncharacterized protein, isoform A; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (876 aa)
	DwilGK25744	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (629 aa)
	DwilGK11781	Uncharacterized protein. (1598 aa)
	DwilGK11381	Uncharacterized protein. (1078 aa)
	DwilGK11633	Uncharacterized protein. (151 aa)
	DwilGK11116	HTH OST-type domain-containing protein. (581 aa)
	DwilGK11117	OSK domain-containing protein. (304 aa)
	DwilGK11135	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1291 aa)
	DwilGK18056	Uncharacterized protein. (909 aa)
	DwilGK18055	DH domain-containing protein. (628 aa)
	DwilGK17824	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (617 aa)
	DwilGK20383	GK20383. (86 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK12371	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1879 aa)
	DwilGK12619	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1867 aa)
	DwilGK16189	UDENN domain-containing protein. (2040 aa)
	DwilGK24828	Uncharacterized protein. (756 aa)
	DwilGK24679	Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (550 aa)
	DwilGK18265	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
	DwilGK22086	Uncharacterized protein, isoform B. (1646 aa)
	DwilGK21125	GBD/FH3 domain-containing protein. (1102 aa)
	DwilGK20641	Nudix hydrolase domain-containing protein. (833 aa)
	DwilGK14913	Uncharacterized protein, isoform A. (1096 aa)
	DwilGK15146	Uncharacterized protein. (296 aa)
	DwilGK15003	Uncharacterized protein. (223 aa)
	DwilGK15093	Uncharacterized protein. (1301 aa)
	DwilGK15399	Myotubularin phosphatase domain-containing protein. (620 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10551	DwilGK10680	B4NLZ7	B4MIP6	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	PH domain-containing protein.	0.834
DwilGK10551	DwilGK11633	B4NLZ7	B4N9S0	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.628
DwilGK10551	DwilGK12619	B4NLZ7	B4N337	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.737
DwilGK10551	DwilGK17233	B4NLZ7	B4MLL0	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.899
DwilGK10551	DwilGK18055	B4NLZ7	B4N6G8	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	DH domain-containing protein.	0.746
DwilGK10551	DwilGK18056	B4NLZ7	B4N6G9	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.746
DwilGK10551	DwilGK23137	B4NLZ7	B4NMF8	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.496
DwilGK10551	DwilGK23171	B4NLZ7	B4NML4	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	PH domain-containing protein.	0.525
DwilGK10641	DwilGK12619	B4MIX8	B4N337	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.422
DwilGK10641	DwilGK14913	B4MIX8	B4MWB5	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein, isoform A.	0.461
DwilGK10641	DwilGK15407	B4MIX8	B4MUZ7	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.775
DwilGK10641	DwilGK16960	B4MIX8	B4MLJ6	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein.	0.483
DwilGK10641	DwilGK17312	B4MIX8	B4NQ65	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein.	0.593
DwilGK10641	DwilGK18265	B4MIX8	B4MZA3	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.444
DwilGK10641	DwilGK23137	B4MIX8	B4NMF8	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein.	0.518
DwilGK10641	DwilGK25227	B4MIX8	B4NES5	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein.	0.543
DwilGK10641	DwilGK25713	B4MIX8	B4NEV8	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.527
DwilGK10680	DwilGK10551	B4MIP6	B4NLZ7	PH domain-containing protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.834
DwilGK10680	DwilGK11633	B4MIP6	B4N9S0	PH domain-containing protein.	Uncharacterized protein.	0.564
DwilGK10680	DwilGK12619	B4MIP6	B4N337	PH domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.990