(39 nodes) Regulation of circadian sleep/wake cycle, sleep network (Drosophila willistoni)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK16572	Uncharacterized protein, isoform B; Belongs to the potassium channel family. (1609 aa)
	DwilGK20784	Uncharacterized protein, isoform B. (1332 aa)
	DwilGK20005	Uncharacterized protein, isoform B. (342 aa)
	DwilGK27530	BTB domain-containing protein. (556 aa)
	DwilGK18142	Uncharacterized protein, isoform E. (468 aa)
	DwilGK10677	Uncharacterized protein. (236 aa)
	DwilGK20939	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (495 aa)
	cue	Protein cueball; Has a role in spermatogenesis and oogenesis. Belongs to the cueball family. (651 aa)
	DwilGK17217	Uncharacterized protein. (410 aa)
	DwilGK16857	Uncharacterized protein. (580 aa)
	DwilHsp83	Hsp83. (721 aa)
	qvr	Protein quiver; Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability (By similarity). (161 aa)
	DwilGK21996	GK21996. (840 aa)
	DwilGK15907	HATPase_c domain-containing protein. (716 aa)
	DwilGK14675	TIMELESS domain-containing protein. (1425 aa)
	DwilGK15458	Uncharacterized protein; Belongs to the protein kinase superfamily. (353 aa)
	DwilGK15028	AMP-binding domain-containing protein. (691 aa)
	DwilGK15027	AMP-binding domain-containing protein. (666 aa)
	DwilGK20284	Uncharacterized protein. (190 aa)
	DwilGK10694	Uncharacterized protein. (998 aa)
	DwilGK18258	CULLIN_2 domain-containing protein; Belongs to the cullin family. (775 aa)
	DwilGK24217	WH1 domain-containing protein. (565 aa)
	DwilGK16320	BTB domain-containing protein. (742 aa)
	DwilGK16425	Aldo_ket_red domain-containing protein. (599 aa)
	DwilGK18674	Angiotensin-converting enzyme. (632 aa)
	DwilGK11138	Uncharacterized protein, isoform B. (1571 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	DwilGK11177	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (804 aa)
	DwilGK24976	F-box domain-containing protein. (703 aa)
	DwilGK22750	Uncharacterized protein. (558 aa)
	DwilGK19118	BTB domain-containing protein. (459 aa)
	DwilGK22423	BTB domain-containing protein. (548 aa)
	DwilGK14107	ETS domain-containing protein. (671 aa)
	DwilGK12949	Uncharacterized protein. (1466 aa)
	DwilGK13802	Photolyase/cryptochrome alpha/beta domain-containing protein. (543 aa)
	DwilGK18403	Uncharacterized protein. (76 aa)
	DwilGK23078	Uncharacterized protein; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (388 aa)
	DwilGK17943	BTB domain-containing protein; Belongs to the potassium channel family. (639 aa)
	DwilGK14663	BTB domain-containing protein. (213 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10694	DwilGK13802	B4MY18	B4NIT5	Uncharacterized protein.	Photolyase/cryptochrome alpha/beta domain-containing protein.	0.798
DwilGK10694	DwilGK14675	B4MY18	B4MV73	Uncharacterized protein.	TIMELESS domain-containing protein.	0.880
DwilGK10694	DwilGK17217	B4MY18	B4MLH5	Uncharacterized protein.	Uncharacterized protein.	0.958
DwilGK10694	DwilGK21996	B4MY18	B4MR44	Uncharacterized protein.	GK21996.	0.472
DwilGK11138	DwilGK24976	B4N7Y2	B4ND39	Uncharacterized protein, isoform B.	F-box domain-containing protein.	0.437
DwilGK12078	DwilGK21996	B4N8K5	B4MR44	Uncharacterized protein.	GK21996.	0.599
DwilGK13802	DwilGK10694	B4NIT5	B4MY18	Photolyase/cryptochrome alpha/beta domain-containing protein.	Uncharacterized protein.	0.798
DwilGK13802	DwilGK14675	B4NIT5	B4MV73	Photolyase/cryptochrome alpha/beta domain-containing protein.	TIMELESS domain-containing protein.	0.950
DwilGK13802	DwilGK17217	B4NIT5	B4MLH5	Photolyase/cryptochrome alpha/beta domain-containing protein.	Uncharacterized protein.	0.928
DwilGK14663	DwilGK18258	B4NPR7	B4MZ92	BTB domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.939
DwilGK14675	DwilGK10694	B4MV73	B4MY18	TIMELESS domain-containing protein.	Uncharacterized protein.	0.880
DwilGK14675	DwilGK13802	B4MV73	B4NIT5	TIMELESS domain-containing protein.	Photolyase/cryptochrome alpha/beta domain-containing protein.	0.950
DwilGK14675	DwilGK17217	B4MV73	B4MLH5	TIMELESS domain-containing protein.	Uncharacterized protein.	0.814
DwilGK15027	DwilGK15028	B4MVN2	B4MVN0	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.943
DwilGK15028	DwilGK15027	B4MVN0	B4MVN2	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.943
DwilGK15907	DwilHsp83	B4MRW8	B4MMG6	HATPase_c domain-containing protein.	Hsp83.	0.900
DwilGK16425	DwilGK16572	B4N246	A0A0Q9WPB4	Aldo_ket_red domain-containing protein.	Uncharacterized protein, isoform B; Belongs to the potassium channel family.	0.657
DwilGK16425	DwilGK17943	B4N246	B4NPI1	Aldo_ket_red domain-containing protein.	BTB domain-containing protein; Belongs to the potassium channel family.	0.950
DwilGK16425	DwilGK20784	B4N246	A0A0Q9WNN2	Aldo_ket_red domain-containing protein.	Uncharacterized protein, isoform B.	0.476
DwilGK16572	DwilGK16425	A0A0Q9WPB4	B4N246	Uncharacterized protein, isoform B; Belongs to the potassium channel family.	Aldo_ket_red domain-containing protein.	0.657