(37 nodes) R8 cell differentiation network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK13592	TGF_BETA_2 domain-containing protein. (525 aa)
	DwilGK10766	Receptor protein-tyrosine kinase. (1386 aa)
	Dwilrho	Rhomboid; Belongs to the peptidase S54 family. (361 aa)
	Dwilvn	Vein. (481 aa)
	DwilGK16654	PH domain-containing protein. (1028 aa)
	DwilGK21397	GK21397. (930 aa)
	DwilGK21386	GK21386. (391 aa)
	DwilGK15709	TGF_BETA_2 domain-containing protein. (457 aa)
	DwilGK15703	Uncharacterized protein. (636 aa)
	DwilGK23721	Serine/threonine-protein phosphatase. (310 aa)
	DwilGK15369	Uncharacterized protein. (1306 aa)
	DwilGK15043	Uncharacterized protein. (970 aa)
	DwilGK19967	Importin N-terminal domain-containing protein. (1051 aa)
	DwilGK18218	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1755 aa)
	DwilGK18219	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1709 aa)
	DwilGK18268	Mothers against decapentaplegic homolog. (514 aa)
	DwilGK24277	TGF_BETA_2 domain-containing protein. (592 aa)
	DwilGK21070	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	DwilGK21101	Uncharacterized protein. (1421 aa)
	DwilGK11118	Uncharacterized protein; Belongs to the MAGUK family. (2450 aa)
	Kibra	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...] (1288 aa)
	DwilGK11390	BHLH domain-containing protein. (331 aa)
	DwilGK25866	FERM domain-containing protein. (636 aa)
	DwilGK10058	Uncharacterized protein, isoform A. (1035 aa)
	DwilGK25063	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (1666 aa)
	DwilGK25062	S8_pro-domain domain-containing protein. (120 aa)
	DwilGK24988	Mothers against decapentaplegic homolog. (490 aa)
	DwilGK13110	Uncharacterized protein. (1146 aa)
	DwilGK13706	TGF_BETA_2 domain-containing protein. (901 aa)
	Dwilsav	Sav. (580 aa)
	DwilGK14450	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
	DwilGK13955	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (669 aa)
	DwilGK14034	Metalloendopeptidase. (912 aa)
	DwilGK15136	Uncharacterized protein; Belongs to the AAA ATPase family. (442 aa)
	DwilGK17989	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (431 aa)
	DwilGK22388	Uncharacterized protein, isoform B; Belongs to the 14-3-3 family. (262 aa)
	DwilGK24370	Uncharacterized protein, isoform C. (742 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10058	DwilGK21386	B4NCK3	B4MQR3	Uncharacterized protein, isoform A.	GK21386.	0.493
DwilGK10766	DwilGK15043	B4MJ19	B4MVK8	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.891
DwilGK10766	DwilGK15369	B4MJ19	B4MUS2	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.545
DwilGK10766	DwilGK21386	B4MJ19	B4MQR3	Receptor protein-tyrosine kinase.	GK21386.	0.815
DwilGK10766	DwilGK21397	B4MJ19	B4MQN8	Receptor protein-tyrosine kinase.	GK21397.	0.437
DwilGK10766	DwilGK23721	B4MJ19	B4MU43	Receptor protein-tyrosine kinase.	Serine/threonine-protein phosphatase.	0.465
DwilGK10766	Dwilrho	B4MJ19	B4MLF4	Receptor protein-tyrosine kinase.	Rhomboid; Belongs to the peptidase S54 family.	0.653
DwilGK10766	Dwilvn	B4MJ19	B4MMK9	Receptor protein-tyrosine kinase.	Vein.	0.975
DwilGK10766	Kibra	B4MJ19	B4NAD3	Receptor protein-tyrosine kinase.	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...]	0.640
DwilGK11118	DwilGK15043	B4N814	B4MVK8	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.512
DwilGK11118	DwilGK18219	B4N814	B4MYV1	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.458
DwilGK11118	DwilGK21386	B4N814	B4MQR3	Uncharacterized protein; Belongs to the MAGUK family.	GK21386.	0.802
DwilGK11118	Kibra	B4N814	B4NAD3	Uncharacterized protein; Belongs to the MAGUK family.	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...]	0.667
DwilGK13110	DwilGK15043	B4NGZ6	B4MVK8	Uncharacterized protein.	Uncharacterized protein.	0.743
DwilGK13110	DwilGK15703	B4NGZ6	B4MRR7	Uncharacterized protein.	Uncharacterized protein.	0.995
DwilGK13110	DwilGK21386	B4NGZ6	B4MQR3	Uncharacterized protein.	GK21386.	0.998
DwilGK13110	DwilGK22388	B4NGZ6	A0A0Q9X1L5	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the 14-3-3 family.	0.528
DwilGK13110	DwilGK25866	B4NGZ6	B4NCJ4	Uncharacterized protein.	FERM domain-containing protein.	0.745
DwilGK13110	Dwilsav	B4NGZ6	B4NHY1	Uncharacterized protein.	Sav.	0.992
DwilGK13110	Kibra	B4NGZ6	B4NAD3	Uncharacterized protein.	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...]	0.985