(65 nodes) Positive regulation of neurogenesis network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK12809	Uncharacterized protein. (201 aa)
	DwilGK14458	Uncharacterized protein. (223 aa)
	DwilGK23144	Uncharacterized protein. (224 aa)
	DwilGK23247	Uncharacterized protein. (617 aa)
	DwilGK17279	Uncharacterized protein. (2653 aa)
	DwilGK16344	Uncharacterized protein. (1710 aa)
	DwilGK12234	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (788 aa)
	DwilGK17105	Uncharacterized protein. (534 aa)
	DwilHsp83	Hsp83. (721 aa)
	DwilGK17436	CS domain-containing protein. (315 aa)
	DwilGK12498	CS domain-containing protein. (326 aa)
	DwilGK20892	Uncharacterized protein. (589 aa)
	DwilGK16325	Uncharacterized protein. (377 aa)
	DwilGK16299	RBR-type E3 ubiquitin transferase. (507 aa)
	DwilGK27490	Ig-like domain-containing protein. (478 aa)
	DwilGK10361	Uncharacterized protein. (2528 aa)
	DwilGK24277	TGF_BETA_2 domain-containing protein. (592 aa)
	DwilGK14619	Uncharacterized protein. (885 aa)
	DwilGK14661	Uncharacterized protein. (385 aa)
	DwilGK15407	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DwilGK23802	CS domain-containing protein. (324 aa)
	DwilGK17304	Uncharacterized protein. (2757 aa)
	DwilGK23810	GCM domain-containing protein. (496 aa)
	DwilGK15907	HATPase_c domain-containing protein. (716 aa)
	DwilGK15770	Uncharacterized protein. (465 aa)
	DwilGK21945	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (997 aa)
	DwilGK21386	GK21386. (391 aa)
	DwilGK21914	GK21914. (733 aa)
	DwilGK21519	GK21519. (222 aa)
	DwilGK21803	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (605 aa)
	DwilGK11290	Uncharacterized protein, isoform B. (1814 aa)
	DwilGK17989	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (431 aa)
	DwilGK19483	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family. (3600 aa)
	DwilGK28247	NUDE_C domain-containing protein. (328 aa)
	DwilGK24370	Uncharacterized protein, isoform C. (742 aa)
	DwilGK12202	Uncharacterized protein, isoform B. (718 aa)
	DwilGK13431	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (684 aa)
	DwilGK17953	Uncharacterized protein, isoform G. (8749 aa)
	DwilGK18880	Uncharacterized protein. (758 aa)
	DwilGK12696	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (423 aa)
	DwilGK10469	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (633 aa)
	DwilGK10424	Uncharacterized protein, isoform A. (1284 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK20520	GK20520. (109 aa)
	DwilGK20531	GK20531. (392 aa)
	DwilGK17881	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (647 aa)
	DwilGK21118	Uncharacterized protein. (1108 aa)
	DwilGK11982	Uncharacterized protein. (503 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	DwilGK10964	Uncharacterized protein, isoform A. (542 aa)
	DwilGK12252	Uncharacterized protein. (330 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (777 aa)
	DwilGK24998	Uncharacterized protein. (1774 aa)
	DwilGK24988	Mothers against decapentaplegic homolog. (490 aa)
	DwilGK24977	BHLH domain-containing protein. (785 aa)
	DwilGK24915	Uncharacterized protein. (3117 aa)
	DwilGK25610	Uncharacterized protein. (626 aa)
	DwilGK22414	Uncharacterized protein. (182 aa)
	DwilGK22387	Homeobox domain-containing protein. (611 aa)
	DwilGK13667	Sema domain-containing protein. (2061 aa)
	DwilGK13684	Uncharacterized protein, isoform A. (1950 aa)
	DwilGK14251	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
	DwilGK13706	TGF_BETA_2 domain-containing protein. (901 aa)
	DwilGK12926	RIO domain-containing protein. (545 aa)
	DwilGK14455	Uncharacterized protein. (209 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10424	DwilGK15907	B4N4P0	B4MRW8	Uncharacterized protein, isoform A.	HATPase_c domain-containing protein.	0.560
DwilGK10424	DwilGK21914	B4N4P0	B4MQP4	Uncharacterized protein, isoform A.	GK21914.	0.464
DwilGK10424	DwilGK28247	B4N4P0	A0A0Q9WZT9	Uncharacterized protein, isoform A.	NUDE_C domain-containing protein.	0.478
DwilGK10424	DwilHsp83	B4N4P0	B4MMG6	Uncharacterized protein, isoform A.	Hsp83.	0.560
DwilGK10469	DwilGK12926	B4N4M5	B4NIU7	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	RIO domain-containing protein.	0.937
DwilGK10964	DwilGK14661	B4N8U3	B4MV91	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.506
DwilGK10964	DwilGK16325	B4N8U3	B4N1K8	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.461
DwilGK10964	spas	B4N8U3	B4NBP4	Uncharacterized protein, isoform A.	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.	0.631
DwilGK12078	DwilGK22414	B4N8K5	B4NG51	Uncharacterized protein.	Uncharacterized protein.	0.456
DwilGK12234	DwilGK14251	A0A0Q9X5J3	B4NHT7	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family.	0.991
DwilGK12234	DwilGK21914	A0A0Q9X5J3	B4MQP4	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	GK21914.	0.738
DwilGK12234	spas	A0A0Q9X5J3	B4NBP4	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.	0.400
DwilGK12498	DwilGK28247	B4N3A7	A0A0Q9WZT9	CS domain-containing protein.	NUDE_C domain-containing protein.	0.656
DwilGK12696	DwilGK19483	B4N3F9	A0A0Q9X069	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family.	0.722
DwilGK12696	DwilGK21945	B4N3F9	B4MQU9	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.981
DwilGK12696	DwilGK23247	B4N3F9	B4NN35	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.853
DwilGK12696	DwilGK25610	B4N3F9	B4NEA1	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.994
DwilGK12809	DwilGK14458	B4NK25	B4NK30	Uncharacterized protein.	Uncharacterized protein.	0.999
DwilGK12926	DwilGK10469	B4NIU7	B4N4M5	RIO domain-containing protein.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.937
DwilGK13667	DwilGK13684	B4NHI8	B4NHL1	Sema domain-containing protein.	Uncharacterized protein, isoform A.	0.532