(48 nodes) Regulation of dendrite development network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Dwilsav	Sav. (580 aa)
	DwilGK13262	Non-specific serine/threonine protein kinase. (531 aa)
	DwilGK13504	Uncharacterized protein. (1019 aa)
	DwilGK13431	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (684 aa)
	DwilGK12202	Uncharacterized protein, isoform B. (718 aa)
	DwilGK13699	TGF_BETA_2 domain-containing protein. (577 aa)
	DwilGK23084	Uncharacterized protein, isoform B. (262 aa)
	DwilGK28247	NUDE_C domain-containing protein. (328 aa)
	DwilGK25350	Uncharacterized protein. (1517 aa)
	DwilGK23295	Uncharacterized protein, isoform C. (573 aa)
	DwilGK12234	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (788 aa)
	DwilGK12150	Uncharacterized protein, isoform B. (2394 aa)
	DwilGK10361	Uncharacterized protein. (2528 aa)
	DwilGK20826	Ig-like domain-containing protein. (200 aa)
	DwilGK17215	Uncharacterized protein; Belongs to the protein kinase superfamily. (461 aa)
	DwilGK17436	CS domain-containing protein. (315 aa)
	DwilGK17571	Uncharacterized protein. (3608 aa)
	DwilGK17105	Uncharacterized protein. (534 aa)
	DwilGK21847	GK21847. (1406 aa)
	DwilGK21914	GK21914. (733 aa)
	DwilGK22019	GK22019. (2234 aa)
	DwilGK23802	CS domain-containing protein. (324 aa)
	DwilGK15265	Uncharacterized protein. (531 aa)
	DwilGK14777	Uncharacterized protein, isoform C. (1654 aa)
	DwilGK15535	Uncharacterized protein. (1073 aa)
	DwilGK20663	Uncharacterized protein. (397 aa)
	DwilGK18219	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1709 aa)
	DwilGK24611	Uncharacterized protein. (1603 aa)
	DwilGK16256	Uncharacterized protein. (1921 aa)
	DwilGK16106	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (496 aa)
	DwilGK12556	POU domain protein. (745 aa)
	DwilGK12498	CS domain-containing protein. (326 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK20520	GK20520. (109 aa)
	DwilGK13260	Non-specific serine/threonine protein kinase. (674 aa)
	DwilGK20582	GK20582. (421 aa)
	DwilGK17749	E3 ubiquitin-protein ligase. (937 aa)
	DwilGK12332	Uncharacterized protein. (886 aa)
	DwilGK21110	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1281 aa)
	DwilGK11385	Uncharacterized protein. (366 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (777 aa)
	DwilGK25120	Uncharacterized protein, isoform A; Belongs to the STXBP/unc-18/SEC1 family. (599 aa)
	DwilGK25821	Uncharacterized protein. (785 aa)
	DwilGK24998	Uncharacterized protein. (1774 aa)
	DwilGK22461	Uncharacterized protein. (2454 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK13110	Uncharacterized protein. (1146 aa)
	DwilGK14251	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10361	DwilGK22461	B4MJC0	B4NFV0	Uncharacterized protein.	Uncharacterized protein.	0.618
DwilGK12150	DwilGK20502	A0A0Q9X5K4	B4N547	Uncharacterized protein, isoform B.	GK20502.	0.488
DwilGK12234	DwilGK14251	A0A0Q9X5J3	B4NHT7	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family.	0.991
DwilGK12234	DwilGK21914	A0A0Q9X5J3	B4MQP4	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	GK21914.	0.738
DwilGK12234	DwilGK25120	A0A0Q9X5J3	B4NCA0	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein, isoform A; Belongs to the STXBP/unc-18/SEC1 family.	0.449
DwilGK12234	spas	A0A0Q9X5J3	B4NBP4	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.	0.400
DwilGK12498	DwilGK16106	B4N3A7	B4N2K3	CS domain-containing protein.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.565
DwilGK12498	DwilGK28247	B4N3A7	A0A0Q9WZT9	CS domain-containing protein.	NUDE_C domain-containing protein.	0.656
DwilGK13110	DwilGK15265	B4NGZ6	B4MUD5	Uncharacterized protein.	Uncharacterized protein.	0.470
DwilGK13110	DwilGK17749	B4NGZ6	B4N6E6	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.740
DwilGK13110	DwilGK25350	B4NGZ6	A0A0Q9X3W3	Uncharacterized protein.	Uncharacterized protein.	0.740
DwilGK13110	Dwilsav	B4NGZ6	B4NHY1	Uncharacterized protein.	Sav.	0.992
DwilGK13260	DwilGK13262	B4NL10	B4NL09	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.900
DwilGK13260	DwilGK15265	B4NL10	B4MUD5	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.815
DwilGK13260	DwilGK16256	B4NL10	B4N1P6	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.858
DwilGK13260	DwilGK20502	B4NL10	B4N547	Non-specific serine/threonine protein kinase.	GK20502.	0.415
DwilGK13260	DwilGK22711	B4NL10	B4NFV1	Non-specific serine/threonine protein kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.795
DwilGK13262	DwilGK13260	B4NL09	B4NL10	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.900
DwilGK13262	DwilGK15265	B4NL09	B4MUD5	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.815
DwilGK13262	DwilGK16256	B4NL09	B4N1P6	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.858