(86 nodes) Cell cortex region network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK15320	Uncharacterized protein. (690 aa)
	DwilGK17953	Uncharacterized protein, isoform G. (8749 aa)
	DwilGK10130	Uncharacterized protein, isoform B. (666 aa)
	DwilGK27403	Uncharacterized protein. (1426 aa)
	DwilGK13659	Uncharacterized protein. (3205 aa)
	DwilGK22469	Uncharacterized protein, isoform C. (765 aa)
	DwilGK17594	Uncharacterized protein, isoform D. (4655 aa)
	DwilGK28239	Uncharacterized protein. (268 aa)
	DwilGK16229	Uncharacterized protein, isoform F; Belongs to the MAGUK family. (973 aa)
	DwilGK17969	Uncharacterized protein. (1207 aa)
	DwilGK12678	Uncharacterized protein, isoform E. (584 aa)
	DwilGK11290	Uncharacterized protein, isoform B. (1814 aa)
	DwilGK10907	Uncharacterized protein, isoform B. (467 aa)
	DwilGK26812	Uncharacterized protein. (100 aa)
	DwilGK20934	CABIT domain-containing protein. (807 aa)
	DwilGK17195	Uncharacterized protein. (355 aa)
	DwilGK17241	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (217 aa)
	DwilGK16812	Uncharacterized protein. (1543 aa)
	DwilGK16977	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (725 aa)
	DwilGK17219	GRASP55_65 domain-containing protein. (500 aa)
	DwilGK17294	SH2 domain-containing protein. (393 aa)
	DwilGK16599	Uncharacterized protein. (978 aa)
	DwilGK21803	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (605 aa)
	DwilGK21818	GK21818. (288 aa)
	DwilGK21819	GK21819. (515 aa)
	DwilGK21820	GK21820. (312 aa)
	DwilGK21821	GK21821. (1148 aa)
	DwilGK21843	GK21843. (1617 aa)
	DwilGK21844	GK21844. (1379 aa)
	DwilGK21918	GK21918. (2615 aa)
	DwilGK21386	GK21386. (391 aa)
	DwilGK21943	GK21943. (668 aa)
	DwilGK15789	UBX domain-containing protein. (442 aa)
	DwilGK15788	Uncharacterized protein. (116 aa)
	DwilGK15703	Uncharacterized protein. (636 aa)
	DwilGK20155	Uncharacterized protein. (2674 aa)
	DwilGK23851	Uncharacterized protein. (1100 aa)
	DwilGK20085	Uncharacterized protein. (1688 aa)
	DwilGK20614	Uncharacterized protein. (486 aa)
	DwilGK22103	Uncharacterized protein. (3288 aa)
	DwilGK22102	Uncharacterized protein. (4799 aa)
	DwilGK22054	Uncharacterized protein. (855 aa)
	DwilGK18265	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
	DwilGK18067	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2167 aa)
	DwilGK24337	Uncharacterized protein. (489 aa)
	DwilGK24796	Uncharacterized protein. (121 aa)
	DwilGK16335	Uncharacterized protein. (200 aa)
	DwilGK16408	Uncharacterized protein. (361 aa)
	DwilGK16488	Uncharacterized protein. (3076 aa)
	DwilGK12542	Uncharacterized protein. (1359 aa)
	DwilGK12507	Uncharacterized protein. (2267 aa)
	DwilGK10424	Uncharacterized protein, isoform A. (1284 aa)
	DwilGK20329	GK20329. (867 aa)
	DwilGK24127	ANK_REP_REGION domain-containing protein. (957 aa)
	DwilGK23617	Uncharacterized protein. (1228 aa)
	DwilGK21118	Uncharacterized protein. (1108 aa)
	DwilGK18706	Uncharacterized protein. (408 aa)
	DwilGK11117	OSK domain-containing protein. (304 aa)
	DwilGK11116	HTH OST-type domain-containing protein. (581 aa)
	DwilGK10886	Uncharacterized protein, isoform D. (2396 aa)
	Kibra	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...] (1288 aa)
	DwilGK11381	Uncharacterized protein. (1078 aa)
	DwilGK11758	TPR_REGION domain-containing protein. (652 aa)
	DwilGK11781	Uncharacterized protein. (1598 aa)
	DwilGK11837	Uncharacterized protein. (2618 aa)
	DwilGK11192	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1400 aa)
	DwilGK25185	Uncharacterized protein, isoform B; Belongs to the MAGUK family. (1169 aa)
	DwilGK25074	Uncharacterized protein. (1095 aa)
	DwilGK25866	FERM domain-containing protein. (636 aa)
	DwilGK25538	PH domain-containing protein. (1250 aa)
	DwilGK25610	Uncharacterized protein. (626 aa)
	DwilGK25324	Uncharacterized protein. (290 aa)
	DwilGK25320	Ras-GAP domain-containing protein. (1980 aa)
	DwilGK25227	Uncharacterized protein. (637 aa)
	DwilGK25713	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1379 aa)
	DwilGK13110	Uncharacterized protein. (1146 aa)
	DwilGK14156	Uncharacterized protein. (851 aa)
	Dwilsav	Sav. (580 aa)
	DwilGK13480	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (863 aa)
	DwilGK23137	Uncharacterized protein. (192 aa)
	DwilGK23256	Uncharacterized protein. (369 aa)
	DwilGK23297	Uncharacterized protein. (1719 aa)
	DwilGK22882	Uncharacterized protein. (830 aa)
	DwilGK17694	Uncharacterized protein. (174 aa)
	DwilGK14763	Uncharacterized protein. (1715 aa)
	DwilGK27507	Uncharacterized protein. (322 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10130	DwilGK10886	A0A0Q9WUC9	B4N9K6	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform D.	0.520
DwilGK10130	DwilGK13110	A0A0Q9WUC9	B4NGZ6	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.976
DwilGK10130	DwilGK21843	A0A0Q9WUC9	B4MQB2	Uncharacterized protein, isoform B.	GK21843.	0.520
DwilGK10130	DwilGK21844	A0A0Q9WUC9	B4MQB3	Uncharacterized protein, isoform B.	GK21844.	0.520
DwilGK10130	Dwilsav	A0A0Q9WUC9	B4NHY1	Uncharacterized protein, isoform B.	Sav.	0.939
DwilGK10424	DwilGK17219	B4N4P0	B4MLH8	Uncharacterized protein, isoform A.	GRASP55_65 domain-containing protein.	0.452
DwilGK10424	DwilGK17594	B4N4P0	A0A0Q9WWM9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform D.	0.754
DwilGK10424	DwilGK23256	B4N4P0	B4NN52	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.536
DwilGK10886	DwilGK10130	B4N9K6	A0A0Q9WUC9	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform B.	0.520
DwilGK10907	DwilGK18265	A0A0Q9X5M6	B4MZA3	Uncharacterized protein, isoform B.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.738
DwilGK10907	DwilGK20085	A0A0Q9X5M6	B4MXF9	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.978
DwilGK10907	DwilGK23137	A0A0Q9X5M6	B4NMF8	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.503
DwilGK10907	DwilGK25185	A0A0Q9X5M6	B4NBV6	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform B; Belongs to the MAGUK family.	0.487
DwilGK11116	DwilGK22054	B4N816	B4MYL8	HTH OST-type domain-containing protein.	Uncharacterized protein.	0.663
DwilGK11117	DwilGK22054	B4N815	B4MYL8	OSK domain-containing protein.	Uncharacterized protein.	0.663
DwilGK11192	DwilGK13480	B4NBF4	B4NIU4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.707
DwilGK11192	DwilGK23617	B4NBF4	B4N730	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.468
DwilGK11381	DwilGK11781	B4NAH1	B4NAU6	Uncharacterized protein.	Uncharacterized protein.	0.598
DwilGK11381	DwilGK25610	B4NAH1	B4NEA1	Uncharacterized protein.	Uncharacterized protein.	0.962
DwilGK11758	DwilGK11781	B4NAQ3	B4NAU6	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.430