(63 nodes) Positive regulation of reproductive process network (Drosophila willistoni)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK27369	IPPc domain-containing protein. (346 aa)
	DwilGK11109	Uncharacterized protein, isoform B; Belongs to the DOCK family. (2012 aa)
	DwilGK12114	Uncharacterized protein. (651 aa)
	DwilGK18181	Uncharacterized protein, isoform B. (5914 aa)
	DwilGK27491	Uncharacterized protein. (177 aa)
	DwilGK27966	IPPc domain-containing protein. (502 aa)
	DwilGK10684	Uncharacterized protein, isoform A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1811 aa)
	DwilGK10766	Receptor protein-tyrosine kinase. (1386 aa)
	DwilGK20913	Uncharacterized protein. (217 aa)
	DwilGK17201	Uncharacterized protein. (1530 aa)
	DwilGK17359	Protein kinase domain-containing protein. (861 aa)
	DwilGK17397	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (186 aa)
	Dwilvn	Vein. (481 aa)
	DwilGK17606	Protein kinase domain-containing protein. (1144 aa)
	DwilGK19639	F-box domain-containing protein. (686 aa)
	DwilGK21971	GK21971; Belongs to the cullin family. (775 aa)
	DwilGK22007	GK22007. (456 aa)
	DwilGK19099	Uncharacterized protein. (141 aa)
	DwilGK15874	Non-specific serine/threonine protein kinase. (1150 aa)
	DwilGK15955	Uncharacterized protein. (213 aa)
	DwilGK19766	Uncharacterized protein, isoform C. (1472 aa)
	DwilGK23859	Receptor protein-tyrosine kinase. (1496 aa)
	DwilGK15250	Uncharacterized protein. (1387 aa)
	DwilGK15261	DUF667 domain-containing protein. (199 aa)
	DwilGK15310	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2447 aa)
	DwilGK15071	Uncharacterized protein. (2090 aa)
	DwilGK15139	Uncharacterized protein. (760 aa)
	DwilGK15227	EGF-like domain-containing protein. (252 aa)
	DwilGK22090	BZIP domain-containing protein. (456 aa)
	DwilGK18093	Rhodanese domain-containing protein. (426 aa)
	DwilGK24272	COesterase domain-containing protein. (962 aa)
	DwilGK24781	Uncharacterized protein. (422 aa)
	DwilGK24503	Uncharacterized protein. (1202 aa)
	DwilGK24576	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (768 aa)
	DwilGK24165	Uncharacterized protein. (441 aa)
	DwilGK16116	Uncharacterized protein. (1845 aa)
	DwilGK16524	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (329 aa)
	DwilGK25628	Uncharacterized protein, isoform C. (690 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK17892	ORC_WH_C domain-containing protein. (717 aa)
	DwilGK18041	Uncharacterized protein. (930 aa)
	DwilGK12333	EGF-like domain-containing protein. (238 aa)
	DwilGK23971	RING-type domain-containing protein. (457 aa)
	DwilGK11032	Rhodanese domain-containing protein. (503 aa)
	DwilGK12076	E2F_TDP domain-containing protein. (886 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	kay	Transcription factor kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra (By similarity). (620 aa)
	DwilGK25826	Uncharacterized protein. (392 aa)
	DwilGK25599	RING-type domain-containing protein. (261 aa)
	DwilGK25249	Protein kinase domain-containing protein. (1146 aa)
	DwilGK22705	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (749 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK12444	Mitogen-activated protein kinase. (371 aa)
	DwilGK13501	Uncharacterized protein. (512 aa)
	DwilGK14377	Uncharacterized protein. (502 aa)
	DwilGK13876	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (530 aa)
	DwilGK13262	Non-specific serine/threonine protein kinase. (531 aa)
	DwilGK13260	Non-specific serine/threonine protein kinase. (674 aa)
	DwilGK22947	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1505 aa)
	DwilGK23281	Phosphatidylinositol 3-kinase catalytic subunit type 3. (931 aa)
	DwilGK23286	VIR_N domain-containing protein. (1884 aa)
	DwilGK22865	J domain-containing protein. (2430 aa)
	DwilGK17694	Uncharacterized protein. (174 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10766	DwilGK12078	B4MJ19	B4N8K5	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.426
DwilGK10766	DwilGK12333	B4MJ19	B4N6L0	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.971
DwilGK10766	DwilGK13260	B4MJ19	B4NL10	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase.	0.435
DwilGK10766	DwilGK13262	B4MJ19	B4NL09	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase.	0.432
DwilGK10766	DwilGK15227	B4MJ19	B4MWA8	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.971
DwilGK10766	DwilGK16524	B4MJ19	B4N2K6	Receptor protein-tyrosine kinase.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.534
DwilGK10766	DwilGK18041	B4MJ19	B4N6E0	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.999
DwilGK10766	DwilGK20502	B4MJ19	B4N547	Receptor protein-tyrosine kinase.	GK20502.	0.542
DwilGK10766	DwilGK22711	B4MJ19	B4NFV1	Receptor protein-tyrosine kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.837
DwilGK10766	DwilGK22947	B4MJ19	B4NN66	Receptor protein-tyrosine kinase.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.590
DwilGK10766	DwilGK23859	B4MJ19	B4MTK0	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.739
DwilGK10766	DwilGK24576	B4MJ19	B4N0G4	Receptor protein-tyrosine kinase.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.822
DwilGK10766	Dwilvn	B4MJ19	B4MMK9	Receptor protein-tyrosine kinase.	Vein.	0.975
DwilGK11032	DwilGK13501	B4N8G9	B4NIQ3	Rhodanese domain-containing protein.	Uncharacterized protein.	0.658
DwilGK11032	DwilGK15955	B4N8G9	B4MS71	Rhodanese domain-containing protein.	Uncharacterized protein.	0.491
DwilGK11032	DwilGK17892	B4N8G9	B4N5N7	Rhodanese domain-containing protein.	ORC_WH_C domain-containing protein.	0.854
DwilGK11032	DwilGK18093	B4N8G9	B4MZ30	Rhodanese domain-containing protein.	Rhodanese domain-containing protein.	0.460
DwilGK11109	DwilGK15955	A0A0Q9WTI9	B4MS71	Uncharacterized protein, isoform B; Belongs to the DOCK family.	Uncharacterized protein.	0.405
DwilGK11109	DwilGK20502	A0A0Q9WTI9	B4N547	Uncharacterized protein, isoform B; Belongs to the DOCK family.	GK20502.	0.812
DwilGK12076	DwilGK15955	B4N8K4	B4MS71	E2F_TDP domain-containing protein.	Uncharacterized protein.	0.781