(33 nodes) G-protein mediated events network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK23786	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1331 aa)
	DwilGK23154	Uncharacterized protein, isoform B. (353 aa)
	DwilGK25343	Uncharacterized protein, isoform B. (377 aa)
	DwilGK15712	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1095 aa)
	DwilGK10290	Uncharacterized protein. (3770 aa)
	DwilGK10291	Uncharacterized protein. (103 aa)
	DwilGK17195	Uncharacterized protein. (355 aa)
	DwilGK17483	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1914 aa)
	DwilGK16713	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1079 aa)
	DwilGK21377	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (666 aa)
	DwilGK21366	GK21366. (396 aa)
	DwilGK19414	GK19414; Belongs to the calmodulin family. (148 aa)
	DwilGK22030	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (700 aa)
	DwilGK22032	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
	DwilGK20007	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1726 aa)
	DwilGK15458	Uncharacterized protein; Belongs to the protein kinase superfamily. (353 aa)
	DwilGK14971	Phosphodiesterase. (836 aa)
	DwilGK15554	Uncharacterized protein. (1124 aa)
	DwilGK24375	Uncharacterized protein, isoform A. (770 aa)
	DwilGK24700	Uncharacterized protein. (806 aa)
	DwilGK24141	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1182 aa)
	DwilGK16493	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (695 aa)
	DwilGK12535	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1158 aa)
	DwilGK12673	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1720 aa)
	DwilGK25662	Uncharacterized protein. (396 aa)
	DwilGK12348	Uncharacterized protein. (347 aa)
	DwilGK13114	Uncharacterized protein. (354 aa)
	DwilGK13113	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. (354 aa)
	DwilGK13063	LMWPc domain-containing protein. (155 aa)
	DwilGK13060	LMWPc domain-containing protein. (164 aa)
	DwilGK12910	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (497 aa)
	DwilGK18424	Uncharacterized protein, isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (2214 aa)
	DwilGK10286	Uncharacterized protein. (67 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK12535	DwilGK13113	B4N305	B4NGY9	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	0.543
DwilGK12535	DwilGK14971	B4N305	B4MVY8	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.911
DwilGK12535	DwilGK15458	B4N305	B4MVA0	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.579
DwilGK12535	DwilGK15554	B4N305	B4MWX8	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.905
DwilGK12535	DwilGK17195	B4N305	B4MKT5	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.530
DwilGK12535	DwilGK20007	B4N305	B4MSP0	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.510
DwilGK12535	DwilGK25662	B4N305	B4N3N3	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.484
DwilGK12673	DwilGK14971	B4N3B2	B4MVY8	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.911
DwilGK12673	DwilGK17195	B4N3B2	B4MKT5	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.463
DwilGK12673	DwilGK20007	B4N3B2	B4MSP0	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.454
DwilGK12673	DwilGK25662	B4N3B2	B4N3N3	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.484
DwilGK12910	DwilGK19414	B4NIX0	B4MR07	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	GK19414; Belongs to the calmodulin family.	0.506
DwilGK13060	DwilGK20007	B4NHA0	B4MSP0	LMWPc domain-containing protein.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.405
DwilGK13060	DwilGK25662	B4NHA0	B4N3N3	LMWPc domain-containing protein.	Uncharacterized protein.	0.484
DwilGK13063	DwilGK20007	B4NH99	B4MSP0	LMWPc domain-containing protein.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.405
DwilGK13063	DwilGK25662	B4NH99	B4N3N3	LMWPc domain-containing protein.	Uncharacterized protein.	0.484
DwilGK13113	DwilGK12535	B4NGY9	B4N305	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.543
DwilGK13113	DwilGK13114	B4NGY9	B4NGY8	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.912
DwilGK13113	DwilGK15458	B4NGY9	B4MVA0	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.913
DwilGK13113	DwilGK21366	B4NGY9	B4MQW4	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	GK21366.	0.974