(49 nodes) Toll Like Receptor 7/8 (TLR7/8) Cascade network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK18589	Ubiquitin-like domain-containing protein. (156 aa)
	DwilGK20005	Uncharacterized protein, isoform B. (342 aa)
	DwilGK25841	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (226 aa)
	DwilGK23361	Protein kinase domain-containing protein. (163 aa)
	DwilGK28304	Uncharacterized protein. (321 aa)
	DwilGK10734	Uncharacterized protein. (813 aa)
	DwilGK17319	UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
	DwilGK21648	GK21648. (397 aa)
	DwilGK21643	GK21643; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	DwilGK21677	GK21677. (374 aa)
	DwilGK21594	GK21594. (281 aa)
	DwilGK21421	GK21421. (383 aa)
	DwilGK21402	GK21402. (127 aa)
	DwilGK22011	GK22011. (208 aa)
	DwilGK19915	Uncharacterized protein. (418 aa)
	DwilGK20056	Protein kinase domain-containing protein. (886 aa)
	DwilGK19779	Ubiquitinyl hydrolase 1. (1157 aa)
	DwilGK23721	Serine/threonine-protein phosphatase. (310 aa)
	DwilGK23715	ANK_REP_REGION domain-containing protein. (531 aa)
	DwilGK20481	Uncharacterized protein. (611 aa)
	DwilGK18192	Mitogen-activated protein kinase. (368 aa)
	DwilGK24609	Uncharacterized protein, isoform A. (128 aa)
	DwilGK24159	Uncharacterized protein. (591 aa)
	DwilGK24830	RHD domain-containing protein. (974 aa)
	DwilGK12522	KxDL domain-containing protein. (205 aa)
	DwilGK13379	Non-specific serine/threonine protein kinase. (1163 aa)
	DwilGK12504	Uncharacterized protein. (526 aa)
	DwilGK17808	Uncharacterized protein. (388 aa)
	DwilGK18676	Uncharacterized protein, isoform A. (309 aa)
	DwilGK11979	Uncharacterized protein. (424 aa)
	kay	Transcription factor kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra (By similarity). (620 aa)
	DwilGK11930	Mitogen-activated protein kinase. (365 aa)
	DwilGK25774	Non-specific serine/threonine protein kinase. (919 aa)
	DwilGK25827	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (977 aa)
	DwilGK25846	Uncharacterized protein, isoform A; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	DwilGK10077	Uncharacterized protein. (610 aa)
	DwilGK10232	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (364 aa)
	DwilGK25249	Protein kinase domain-containing protein. (1146 aa)
	DwilGK25671	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (336 aa)
	DwilGK22593	Uncharacterized protein. (506 aa)
	DwilGK22795	C3H1-type domain-containing protein. (528 aa)
	DwilGK12444	Mitogen-activated protein kinase. (371 aa)
	DwilGK13744	Protein kinase domain-containing protein. (580 aa)
	DwilGK18964	Mitogen-activated protein kinase. (352 aa)
	DwilGK14018	Protein kinase domain-containing protein. (603 aa)
	DwilGK14061	Uncharacterized protein. (929 aa)
	DwilGK14073	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (426 aa)
	DwilGK10525	RHD domain-containing protein. (701 aa)
	DwilGK23220	Protein kinase domain-containing protein. (1004 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10077	DwilGK10525	B4NCP0	B4NM36	Uncharacterized protein.	RHD domain-containing protein.	0.431
DwilGK10077	DwilGK10734	B4NCP0	B4MIV3	Uncharacterized protein.	Uncharacterized protein.	0.755
DwilGK10077	DwilGK12522	B4NCP0	B4N341	Uncharacterized protein.	KxDL domain-containing protein.	0.495
DwilGK10077	DwilGK14018	B4NCP0	B4NL18	Uncharacterized protein.	Protein kinase domain-containing protein.	0.528
DwilGK10077	DwilGK14061	B4NCP0	B4NL92	Uncharacterized protein.	Uncharacterized protein.	0.429
DwilGK10077	DwilGK17319	B4NCP0	B4MM13	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.903
DwilGK10077	DwilGK17808	B4NCP0	B4N638	Uncharacterized protein.	Uncharacterized protein.	0.501
DwilGK10077	DwilGK18589	B4NCP0	B4NQD0	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.988
DwilGK10077	DwilGK18676	B4NCP0	B4N7R2	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.481
DwilGK10077	DwilGK19779	B4NCP0	B4MT42	Uncharacterized protein.	Ubiquitinyl hydrolase 1.	0.483
DwilGK10077	DwilGK19915	B4NCP0	B4MSF1	Uncharacterized protein.	Uncharacterized protein.	0.858
DwilGK10077	DwilGK20056	B4NCP0	B4MSY3	Uncharacterized protein.	Protein kinase domain-containing protein.	0.563
DwilGK10077	DwilGK21643	B4NCP0	B4MPA6	Uncharacterized protein.	GK21643; Belongs to the ubiquitin-conjugating enzyme family.	0.853
DwilGK10077	DwilGK22593	B4NCP0	B4NF78	Uncharacterized protein.	Uncharacterized protein.	0.517
DwilGK10077	DwilGK23715	B4NCP0	B4MU63	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.429
DwilGK10077	DwilGK23721	B4NCP0	B4MU43	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.491
DwilGK10077	DwilGK24159	B4NCP0	B4N0Z0	Uncharacterized protein.	Uncharacterized protein.	0.491
DwilGK10077	DwilGK24609	B4NCP0	B4N0N3	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.992
DwilGK10077	DwilGK24830	B4NCP0	B4N1B1	Uncharacterized protein.	RHD domain-containing protein.	0.431
DwilGK10077	DwilGK25846	B4NCP0	B4NCF9	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the ubiquitin-conjugating enzyme family.	0.853