(23 nodes) FCERI mediated MAPK activation network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK17655	Uncharacterized protein, isoform B. (996 aa)
	DwilGK10660	Uncharacterized protein. (211 aa)
	DwilGK17307	Uncharacterized protein. (245 aa)
	DwilGK17568	Uncharacterized protein. (454 aa)
	DwilGK21594	GK21594. (281 aa)
	DwilGK15247	Uncharacterized protein. (379 aa)
	DwilGK25249	Protein kinase domain-containing protein. (1146 aa)
	DwilGK24932	Uncharacterized protein, isoform C. (201 aa)
	DwilGK25059	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1281 aa)
	kay	Transcription factor kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra (By similarity). (620 aa)
	DwilGK24247	DDE Tnp4 domain-containing protein. (578 aa)
	DwilGK17751	Uncharacterized protein. (1055 aa)
	DwilGK20502	GK20502. (192 aa)
	DwilGK10437	Uncharacterized protein. (423 aa)
	DwilGK25178	DDE Tnp4 domain-containing protein. (477 aa)
	DwilGK24390	Uncharacterized protein. (1586 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DwilGK16082	Uncharacterized protein. (256 aa)
	DwilGK14073	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (426 aa)
	DwilGK14065	Non-specific serine/threonine protein kinase. (589 aa)
	DwilGK14117	SH2 domain-containing protein. (210 aa)
	DwilGK12444	Mitogen-activated protein kinase. (371 aa)
	DwilGK27242	DDE Tnp4 domain-containing protein. (206 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10660	DwilGK14065	B4MIT0	B4NL97	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.567
DwilGK10660	DwilGK14117	B4MIT0	B4NGS4	Uncharacterized protein.	SH2 domain-containing protein.	0.957
DwilGK10660	DwilGK17568	B4MIT0	B4MMR9	Uncharacterized protein.	Uncharacterized protein.	0.985
DwilGK10660	DwilGK17655	B4MIT0	A0A0Q9X8V1	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.944
DwilGK10660	DwilGK17751	B4MIT0	B4N6E1	Uncharacterized protein.	Uncharacterized protein.	0.697
DwilGK10660	DwilGK20502	B4MIT0	B4N547	Uncharacterized protein.	GK20502.	0.520
DwilGK10660	DwilGK24390	B4MIT0	B4N0X6	Uncharacterized protein.	Uncharacterized protein.	0.999
DwilGK10660	DwilGK24932	B4MIT0	B4NDD6	Uncharacterized protein.	Uncharacterized protein, isoform C.	0.705
DwilGK10660	DwilGK25059	B4MIT0	B4NCL7	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.964
DwilGK10660	Ras85D	B4MIT0	B4NJ72	Uncharacterized protein.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.971
DwilGK12444	DwilGK14065	B4NGJ8	B4NL97	Mitogen-activated protein kinase.	Non-specific serine/threonine protein kinase.	0.537
DwilGK12444	DwilGK14073	B4NGJ8	B4NLB2	Mitogen-activated protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.997
DwilGK12444	DwilGK17751	B4NGJ8	B4N6E1	Mitogen-activated protein kinase.	Uncharacterized protein.	0.450
DwilGK12444	DwilGK20502	B4NGJ8	B4N547	Mitogen-activated protein kinase.	GK20502.	0.962
DwilGK12444	DwilGK21594	B4NGJ8	B4MPI6	Mitogen-activated protein kinase.	GK21594.	0.998
DwilGK12444	DwilGK24932	B4NGJ8	B4NDD6	Mitogen-activated protein kinase.	Uncharacterized protein, isoform C.	0.450
DwilGK12444	DwilGK25249	B4NGJ8	B4NEN2	Mitogen-activated protein kinase.	Protein kinase domain-containing protein.	0.996
DwilGK12444	Ras85D	B4NGJ8	B4NJ72	Mitogen-activated protein kinase.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.469
DwilGK12444	kay	B4NGJ8	B4NBL5	Mitogen-activated protein kinase.	Transcription factor kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra (By similarity).	0.989
DwilGK14065	DwilGK10660	B4NL97	B4MIT0	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.567