(66 nodes) FoxO signaling pathway network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK27764	Uncharacterized protein. (334 aa)
	DwilGK14491	Uncharacterized protein, isoform C. (916 aa)
	DwilGK27294	IlGF domain-containing protein. (136 aa)
	DwilGK17989	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (431 aa)
	DwilGK23361	Protein kinase domain-containing protein. (163 aa)
	DwilGK10660	Uncharacterized protein. (211 aa)
	DwilGK10766	Receptor protein-tyrosine kinase. (1386 aa)
	DwilGK10295	Uncharacterized protein. (117 aa)
	DwilGK17166	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (331 aa)
	DwilGK17233	Uncharacterized protein. (575 aa)
	DwilGK17547	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (116 aa)
	DwilGK21796	GK21796. (154 aa)
	DwilGK21840	GK21840; Belongs to the cyclin family. (557 aa)
	DwilGK15671	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (217 aa)
	DwilGK15265	Uncharacterized protein. (531 aa)
	DwilGK15314	Uncharacterized protein. (795 aa)
	DwilGK15483	Fork-head domain-containing protein. (346 aa)
	DwilGK15484	Fork-head domain-containing protein. (337 aa)
	DwilGK21025	Protein kinase domain-containing protein. (886 aa)
	SAK	Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...] (787 aa)
	DwilGK18192	Mitogen-activated protein kinase. (368 aa)
	DwilGK24758	acidPPc domain-containing protein. (358 aa)
	DwilGK24448	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (367 aa)
	DwilGK24390	Uncharacterized protein. (1586 aa)
	DwilGK24217	WH1 domain-containing protein. (565 aa)
	DwilGK16501	Uncharacterized protein. (119 aa)
	DwilGK10990	IlGF domain-containing protein. (151 aa)
	DwilGK10979	IlGF domain-containing protein. (148 aa)
	DwilGK12121	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (506 aa)
	DwilGK12401	Uncharacterized protein. (363 aa)
	DwilGK20588	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (520 aa)
	DwilGK17956	Uncharacterized protein. (641 aa)
	DwilGK17957	Uncharacterized protein. (647 aa)
	DwilGK12337	Uncharacterized protein. (209 aa)
	DwilGK18754	Catalase domain-containing protein. (506 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	DwilGK12091	Uncharacterized protein. (891 aa)
	DwilGK11443	F-box domain-containing protein. (590 aa)
	DwilGK11375	CYCLIN domain-containing protein; Belongs to the cyclin family. (578 aa)
	DwilGK11724	Mothers against decapentaplegic homolog. (794 aa)
	DwilGK11930	Mitogen-activated protein kinase. (365 aa)
	DwilGK25150	Uncharacterized protein. (774 aa)
	DwilGK25111	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (397 aa)
	DwilGK25042	Uncharacterized protein; Belongs to the peptidase C19 family. (1174 aa)
	DwilGK24988	Mothers against decapentaplegic homolog. (490 aa)
	DwilGK22559	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (435 aa)
	DwilGK22506	Uncharacterized protein. (121 aa)
	DwilGK22484	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (297 aa)
	DwilGK22483	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (344 aa)
	foxo	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (628 aa)
	DwilGK22466	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (314 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK22753	Uncharacterized protein; Belongs to the cyclin family. (583 aa)
	DwilGK12444	Mitogen-activated protein kinase. (371 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DwilGK18964	Mitogen-activated protein kinase. (352 aa)
	DwilGK13389	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (389 aa)
	DwilGK12780	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2778 aa)
	DwilGK13949	Protein kinase domain-containing protein. (564 aa)
	DwilGK13262	Non-specific serine/threonine protein kinase. (531 aa)
	DwilGK13260	Non-specific serine/threonine protein kinase. (674 aa)
	DwilGK14018	Protein kinase domain-containing protein. (603 aa)
	DwilGK18374	Uncharacterized protein. (528 aa)
	DwilGK23260	AMPKBI domain-containing protein. (341 aa)
	DwilGK15308	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (504 aa)
	DwilGK16296	Non-specific serine/threonine protein kinase. (592 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10295	DwilGK10979	B4MJ58	B4N494	Uncharacterized protein.	IlGF domain-containing protein.	0.957
DwilGK10295	DwilGK10990	B4MJ58	B4N493	Uncharacterized protein.	IlGF domain-containing protein.	0.956
DwilGK10295	DwilGK12078	B4MJ58	B4N8K5	Uncharacterized protein.	Uncharacterized protein.	0.958
DwilGK10295	DwilGK12091	B4MJ58	B4N8M4	Uncharacterized protein.	Uncharacterized protein.	0.924
DwilGK10295	DwilGK27294	B4MJ58	A0A0Q9X2I9	Uncharacterized protein.	IlGF domain-containing protein.	0.957
DwilGK10295	foxo	B4MJ58	B4NFR1	Uncharacterized protein.	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...]	0.461
DwilGK10660	DwilGK10766	B4MIT0	B4MJ19	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.998
DwilGK10660	DwilGK10979	B4MIT0	B4N494	Uncharacterized protein.	IlGF domain-containing protein.	0.531
DwilGK10660	DwilGK11930	B4MIT0	B4NBM5	Uncharacterized protein.	Mitogen-activated protein kinase.	0.439
DwilGK10660	DwilGK12078	B4MIT0	B4N8K5	Uncharacterized protein.	Uncharacterized protein.	0.959
DwilGK10660	DwilGK12091	B4MIT0	B4N8M4	Uncharacterized protein.	Uncharacterized protein.	0.943
DwilGK10660	DwilGK13260	B4MIT0	B4NL10	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.452
DwilGK10660	DwilGK13262	B4MIT0	B4NL09	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.452
DwilGK10660	DwilGK18192	B4MIT0	B4MYQ6	Uncharacterized protein.	Mitogen-activated protein kinase.	0.439
DwilGK10660	DwilGK18374	B4MIT0	B4NLM7	Uncharacterized protein.	Uncharacterized protein.	0.927
DwilGK10660	DwilGK18964	B4MIT0	B4NJI8	Uncharacterized protein.	Mitogen-activated protein kinase.	0.439
DwilGK10660	DwilGK21025	B4MIT0	B4MXB7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.623
DwilGK10660	DwilGK22711	B4MIT0	B4NFV1	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.760
DwilGK10660	DwilGK24390	B4MIT0	B4N0X6	Uncharacterized protein.	Uncharacterized protein.	0.999
DwilGK10660	DwilGK25111	B4MIT0	B4NCB4	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.612