(61 nodes) Phosphatidylinositol signaling system network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK28263	SAC domain-containing protein. (1228 aa)
	DwilGK23786	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1331 aa)
	DwilGK27586	IPPc domain-containing protein. (750 aa)
	DwilGK25304	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (711 aa)
	DwilGK27203	Uncharacterized protein. (423 aa)
	DwilGK27125	IPPc domain-containing protein. (815 aa)
	DwilGK16220	Diacylglycerol kinase. (660 aa)
	DwilGK28140	Uncharacterized protein. (854 aa)
	DwilGK15712	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1095 aa)
	DwilGK20789	PIPK domain-containing protein. (772 aa)
	DwilGK17369	Inositol-1-monophosphatase. (279 aa)
	DwilGK16697	Uncharacterized protein. (175 aa)
	DwilGK17416	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (268 aa)
	DwilGK17653	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1646 aa)
	DwilGK19565	Kinase; Belongs to the inositol phosphokinase (IPK) family. (977 aa)
	DwilGK21452	GK21452. (158 aa)
	DwilGK21353	Diacylglycerol kinase. (1239 aa)
	DwilGK19414	GK19414; Belongs to the calmodulin family. (148 aa)
	DwilGK21975	GK21975; Belongs to the calmodulin family. (147 aa)
	DwilGK22030	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (700 aa)
	DwilGK22032	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
	DwilGK20073	Kinase; Belongs to the inositol phosphokinase (IPK) family. (454 aa)
	DwilGK15265	Uncharacterized protein. (531 aa)
	DwilGK15332	Uncharacterized protein. (2843 aa)
	DwilGK15399	Myotubularin phosphatase domain-containing protein. (620 aa)
	DwilGK20000	Phosphatidate cytidylyltransferase; Belongs to the CDS family. (455 aa)
	DwilGK21146	SAC domain-containing protein. (590 aa)
	DwilGK22183	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	DwilGK24631	Kinase; Belongs to the inositol phosphokinase (IPK) family. (342 aa)
	DwilGK24866	Kinase; Belongs to the inositol phosphokinase (IPK) family. (454 aa)
	DwilGK12371	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1879 aa)
	DwilGK20398	GK20398. (704 aa)
	DwilGK17833	Diacylglycerol kinase. (551 aa)
	DwilGK24463	Inositol-1-monophosphatase. (284 aa)
	DwilGK24473	Inositol-1-monophosphatase. (281 aa)
	DwilGK24484	Inositol-1-monophosphatase. (290 aa)
	DwilGK21094	Uncharacterized protein. (149 aa)
	DwilGK12027	Diacylglycerol kinase. (1772 aa)
	DwilGK11488	Diacylglycerol kinase. (1550 aa)
	DwilGK25720	Uncharacterized protein. (1297 aa)
	DwilGK25174	PH domain-containing protein. (1247 aa)
	DwilGK25095	Uncharacterized protein. (152 aa)
	DwilGK25066	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2134 aa)
	DwilGK25059	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1281 aa)
	DwilGK22680	Uncharacterized protein. (372 aa)
	DwilGK22694	Uncharacterized protein. (149 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK22749	Uncharacterized protein, isoform A. (1147 aa)
	DwilGK13624	PIPK domain-containing protein. (404 aa)
	DwilGK13780	PI3K/PI4K domain-containing protein. (600 aa)
	DwilGK18987	Uncharacterized protein. (167 aa)
	DwilGK18988	Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
	DwilGK18374	Uncharacterized protein. (528 aa)
	DwilGK23060	Uncharacterized protein. (762 aa)
	DwilGK23281	Phosphatidylinositol 3-kinase catalytic subunit type 3. (931 aa)
	DwilGK23304	Myotubularin phosphatase domain-containing protein. (735 aa)
	DwilGK23306	Uncharacterized protein. (1831 aa)
	DwilGK22881	PIPK domain-containing protein. (780 aa)
	DwilGK23328	Uncharacterized protein. (659 aa)
	DwilGK15267	Uncharacterized protein. (155 aa)
	DwilGK15994	CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (226 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK11488	DwilGK15712	B4N9E3	A0A0Q9X6K4	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.931
DwilGK11488	DwilGK20000	B4N9E3	B4MXE3	Diacylglycerol kinase.	Phosphatidate cytidylyltransferase; Belongs to the CDS family.	0.932
DwilGK11488	DwilGK23786	B4N9E3	A0A0Q9WRM6	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.947
DwilGK11488	DwilGK25059	B4N9E3	B4NCL7	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.910
DwilGK12027	DwilGK15712	B4N8C6	A0A0Q9X6K4	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.903
DwilGK12027	DwilGK20000	B4N8C6	B4MXE3	Diacylglycerol kinase.	Phosphatidate cytidylyltransferase; Belongs to the CDS family.	0.905
DwilGK12027	DwilGK23786	B4N8C6	A0A0Q9WRM6	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.903
DwilGK12027	DwilGK25059	B4N8C6	B4NCL7	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.907
DwilGK12371	DwilGK13780	B4N4K5	B4NIP6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	PI3K/PI4K domain-containing protein.	0.908
DwilGK12371	DwilGK15265	B4N4K5	B4MUD5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.944
DwilGK12371	DwilGK15399	B4N4K5	B4MUY5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Myotubularin phosphatase domain-containing protein.	0.962
DwilGK12371	DwilGK15712	B4N4K5	A0A0Q9X6K4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.902
DwilGK12371	DwilGK15994	B4N4K5	B4NQ43	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	CDP-diacylglycerol--inositol 3-phosphatidyltransferase.	0.900
DwilGK12371	DwilGK17653	B4N4K5	B4MN82	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family.	0.901
DwilGK12371	DwilGK18374	B4N4K5	B4NLM7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.960
DwilGK12371	DwilGK20789	B4N4K5	B4MJL7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	PIPK domain-containing protein.	0.912
DwilGK12371	DwilGK21146	B4N4K5	B4MXY9	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	SAC domain-containing protein.	0.900
DwilGK12371	DwilGK22711	B4N4K5	B4NFV1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.675
DwilGK12371	DwilGK22749	B4N4K5	B4NG12	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein, isoform A.	0.900
DwilGK12371	DwilGK22881	B4N4K5	B4NNJ1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	PIPK domain-containing protein.	0.912