(97 nodes) mTOR signaling pathway network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK28245	Uncharacterized protein. (84 aa)
	DwilGK27265	RRM domain-containing protein. (469 aa)
	DwilGK14296	Uncharacterized protein, isoform B. (567 aa)
	DwilGK27764	Uncharacterized protein. (334 aa)
	DwilGK27587	Raptor_N domain-containing protein. (1479 aa)
	DwilGK17534	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
	DwilGK27294	IlGF domain-containing protein. (136 aa)
	DwilGK23361	Protein kinase domain-containing protein. (163 aa)
	DwilGK10660	Uncharacterized protein. (211 aa)
	DwilGK10295	Uncharacterized protein. (117 aa)
	DwilGK17185	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (229 aa)
	DwilGK17201	Uncharacterized protein. (1530 aa)
	DwilGK16938	Rap-GAP domain-containing protein. (1845 aa)
	DwilGK17359	Protein kinase domain-containing protein. (861 aa)
	DwilGK21742	GK21742; Belongs to the WD repeat SEC13 family. (356 aa)
	DwilGK21478	GK21478. (591 aa)
	DwilGK21945	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (997 aa)
	DwilGK22030	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (700 aa)
	DwilGK22032	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
	DwilGK15749	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	DwilGK15922	Uncharacterized protein. (1633 aa)
	DwilGK19795	Uncharacterized protein. (101 aa)
	DwilGK15265	Uncharacterized protein. (531 aa)
	DwilGK15310	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2447 aa)
	DwilGK15126	Uncharacterized protein, isoform A. (541 aa)
	DwilGK15144	Uncharacterized protein. (894 aa)
	DwilGK15307	Uncharacterized protein. (614 aa)
	DwilGK15309	Uncharacterized protein. (588 aa)
	DwilGK14815	Uncharacterized protein. (614 aa)
	DwilGK20927	Uncharacterized protein, isoform A; Belongs to the eukaryotic initiation factor 4E family. (266 aa)
	DwilGK21025	Protein kinase domain-containing protein. (886 aa)
	DwilGK18423	Uncharacterized protein. (180 aa)
	DwilGK16740	Uncharacterized protein. (174 aa)
	DwilGK22115	Uncharacterized protein. (358 aa)
	DwilGK24299	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (472 aa)
	DwilGK24297	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (220 aa)
	Dwilwg	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (477 aa)
	DwilGK24728	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (497 aa)
	DwilGK24390	Uncharacterized protein. (1586 aa)
	DwilGK24182	Uncharacterized protein. (123 aa)
	DwilGK16256	Uncharacterized protein. (1921 aa)
	DwilGK16243	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (360 aa)
	DwilGK12583	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (235 aa)
	DwilGK12696	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (423 aa)
	DwilGK25541	UDENN FLCN/SMCR8-type domain-containing protein. (469 aa)
	DwilGK10990	IlGF domain-containing protein. (151 aa)
	DwilGK10979	IlGF domain-containing protein. (148 aa)
	DwilGK12461	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (826 aa)
	DwilGK20434	GK20434. (1426 aa)
	DwilGK17738	Uncharacterized protein. (339 aa)
	DwilGK21065	Uncharacterized protein. (506 aa)
	DwilGK11128	Uncharacterized protein. (1076 aa)
	DwilGK12034	Uncharacterized protein. (517 aa)
	DwilGK12078	Uncharacterized protein. (1910 aa)
	DwilGK12091	Uncharacterized protein. (891 aa)
	DwilGK12168	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (260 aa)
	DwilGK12172	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
	DwilGK11443	F-box domain-containing protein. (590 aa)
	DwilGK11167	WD_REPEATS_REGION domain-containing protein. (763 aa)
	DwilGK11157	Uncharacterized protein. (1132 aa)
	DwilGK11937	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (279 aa)
	DwilGK25730	Uncharacterized protein. (170 aa)
	DwilGK25774	Non-specific serine/threonine protein kinase. (919 aa)
	DwilGK25150	Uncharacterized protein. (774 aa)
	DwilGK25820	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (642 aa)
	DwilGK25826	Uncharacterized protein. (392 aa)
	DwilGK25111	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (397 aa)
	DwilGK25015	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (248 aa)
	DwilGK24913	Uncharacterized protein. (250 aa)
	DwilGK25539	WD_REPEATS_REGION domain-containing protein. (311 aa)
	DwilGK25580	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (300 aa)
	DwilGK25610	Uncharacterized protein. (626 aa)
	DwilGK25677	Uncharacterized protein. (306 aa)
	DwilGK22514	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (117 aa)
	DwilGK22511	Uncharacterized protein. (226 aa)
	DwilGK22486	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family. (368 aa)
	DwilGK22711	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1113 aa)
	DwilGK22414	Uncharacterized protein. (182 aa)
	DwilGK13026	Uncharacterized protein. (144 aa)
	DwilGK14255	Rab-GAP TBC domain-containing protein. (248 aa)
	DwilGK13566	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (490 aa)
	DwilGK14373	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (235 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DwilGK13358	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (309 aa)
	DwilGK13949	Protein kinase domain-containing protein. (564 aa)
	DwilGK13262	Non-specific serine/threonine protein kinase. (531 aa)
	DwilGK13260	Non-specific serine/threonine protein kinase. (674 aa)
	DwilGK14018	Protein kinase domain-containing protein. (603 aa)
	DwilGK18374	Uncharacterized protein. (528 aa)
	DwilGK18363	Uncharacterized protein. (974 aa)
	DwilGK10548	Uncharacterized protein. (507 aa)
	DwilGK23137	Uncharacterized protein. (192 aa)
	DwilGK23042	Uncharacterized protein, isoform C. (1069 aa)
	DwilGK23039	Uncharacterized protein. (390 aa)
	DwilGK23028	Uncharacterized protein. (247 aa)
	DwilGK23000	Robl_LC7 domain-containing protein. (125 aa)
	DwilGK16296	Non-specific serine/threonine protein kinase. (592 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10295	DwilGK10979	B4MJ58	B4N494	Uncharacterized protein.	IlGF domain-containing protein.	0.957
DwilGK10295	DwilGK10990	B4MJ58	B4N493	Uncharacterized protein.	IlGF domain-containing protein.	0.956
DwilGK10295	DwilGK12078	B4MJ58	B4N8K5	Uncharacterized protein.	Uncharacterized protein.	0.958
DwilGK10295	DwilGK12091	B4MJ58	B4N8M4	Uncharacterized protein.	Uncharacterized protein.	0.924
DwilGK10295	DwilGK27294	B4MJ58	A0A0Q9X2I9	Uncharacterized protein.	IlGF domain-containing protein.	0.957
DwilGK10548	DwilGK12034	B4NM02	B4N8D7	Uncharacterized protein.	Uncharacterized protein.	0.902
DwilGK10548	DwilGK14296	B4NM02	A0A0Q9WVG6	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.949
DwilGK10548	DwilGK21065	B4NM02	B4N798	Uncharacterized protein.	Uncharacterized protein.	0.903
DwilGK10660	DwilGK10979	B4MIT0	B4N494	Uncharacterized protein.	IlGF domain-containing protein.	0.531
DwilGK10660	DwilGK12078	B4MIT0	B4N8K5	Uncharacterized protein.	Uncharacterized protein.	0.959
DwilGK10660	DwilGK12091	B4MIT0	B4N8M4	Uncharacterized protein.	Uncharacterized protein.	0.943
DwilGK10660	DwilGK13260	B4MIT0	B4NL10	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.452
DwilGK10660	DwilGK13262	B4MIT0	B4NL09	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.452
DwilGK10660	DwilGK18374	B4MIT0	B4NLM7	Uncharacterized protein.	Uncharacterized protein.	0.927
DwilGK10660	DwilGK21025	B4MIT0	B4MXB7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.623
DwilGK10660	DwilGK22414	B4MIT0	B4NG51	Uncharacterized protein.	Uncharacterized protein.	0.428
DwilGK10660	DwilGK22711	B4MIT0	B4NFV1	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.760
DwilGK10660	DwilGK23137	B4MIT0	B4NMF8	Uncharacterized protein.	Uncharacterized protein.	0.509
DwilGK10660	DwilGK24390	B4MIT0	B4N0X6	Uncharacterized protein.	Uncharacterized protein.	0.999
DwilGK10660	DwilGK25111	B4MIT0	B4NCB4	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.612