(40 nodes) TGF-beta signaling pathway network (Drosophila willistoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DwilGK17534	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
	DwilGK17989	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (431 aa)
	DwilGK23361	Protein kinase domain-containing protein. (163 aa)
	DwilGK15981	RING-type domain-containing protein. (112 aa)
	DwilGK10721	Uncharacterized protein. (1075 aa)
	DwilGK20831	RING-type domain-containing protein. (112 aa)
	DwilGK20901	Zinc finger FYVE domain-containing protein. (1296 aa)
	DwilGK17325	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (147 aa)
	DwilGK17326	Uncharacterized protein; Belongs to the SKP1 family. (158 aa)
	DwilGK21971	GK21971; Belongs to the cullin family. (775 aa)
	DwilGK21342	GK21342; Belongs to the SKP1 family. (161 aa)
	DwilGK15709	TGF_BETA_2 domain-containing protein. (457 aa)
	DwilGK19998	Uncharacterized protein. (833 aa)
	DwilGK23940	TGF_BETA_2 domain-containing protein. (603 aa)
	DwilGK23721	Serine/threonine-protein phosphatase. (310 aa)
	DwilGK14879	Uncharacterized protein. (1291 aa)
	DwilGK13170	RING-type domain-containing protein. (121 aa)
	DwilGK22220	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (573 aa)
	DwilGK18268	Mothers against decapentaplegic homolog. (514 aa)
	DwilGK24159	Uncharacterized protein. (591 aa)
	DwilGK16427	RING-type domain-containing protein. (108 aa)
	DwilGK16428	Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
	DwilGK20357	GK20357. (123 aa)
	DwilGK18023	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (934 aa)
	DwilGK21070	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
	DwilGK21054	E2F_TDP domain-containing protein. (379 aa)
	DwilGK11724	Mothers against decapentaplegic homolog. (794 aa)
	DwilGK24988	Mothers against decapentaplegic homolog. (490 aa)
	DwilGK24977	BHLH domain-containing protein. (785 aa)
	Dwilsog	Short gastrulation. (950 aa)
	DwilGK25713	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1379 aa)
	DwilGK22408	Uncharacterized protein; Belongs to the SKP1 family. (144 aa)
	DwilGK13706	TGF_BETA_2 domain-containing protein. (901 aa)
	DwilGK14450	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
	DwilGK14024	Uncharacterized protein. (815 aa)
	DwilGK23137	Uncharacterized protein. (192 aa)
	DwilGK23150	Uncharacterized protein. (1444 aa)
	DwilGK23055	Uncharacterized protein; Belongs to the SKP1 family. (154 aa)
	DwilGK18099	RING-type domain-containing protein. (160 aa)
	DwilGK10799	Zf-rbx1 domain-containing protein. (112 aa)

Your Current Organism:

Drosophila willistoni

NCBI taxonomy Id: 7260
Other names: D. willistoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DwilGK10721	DwilGK11724	B4MIS4	B4NAI3	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.899
DwilGK10721	DwilGK14450	B4MIS4	B4NK20	Uncharacterized protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.663
DwilGK10721	DwilGK17534	B4MIS4	A0A0Q9X1F0	Uncharacterized protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.404
DwilGK10721	DwilGK17989	B4MIS4	A0A0Q9X2Q0	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.969
DwilGK10721	DwilGK18023	B4MIS4	B4N6A0	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.696
DwilGK10721	DwilGK18268	B4MIS4	B4MZB1	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.839
DwilGK10721	DwilGK21070	B4MIS4	B4N790	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.701
DwilGK10721	DwilGK22220	B4MIS4	B4MYH3	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.699
DwilGK10721	DwilGK23137	B4MIS4	B4NMF8	Uncharacterized protein.	Uncharacterized protein.	0.706
DwilGK10721	DwilGK23940	B4MIS4	B4MU02	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.681
DwilGK10721	DwilGK24988	B4MIS4	B4ND09	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.905
DwilGK10799	DwilGK16428	B4NRD7	B4N250	Zf-rbx1 domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.887
DwilGK10799	DwilGK17325	B4NRD7	B4MM20	Zf-rbx1 domain-containing protein.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.887
DwilGK10799	DwilGK17326	B4NRD7	B4MM22	Zf-rbx1 domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.887
DwilGK10799	DwilGK21342	B4NRD7	B4MR16	Zf-rbx1 domain-containing protein.	GK21342; Belongs to the SKP1 family.	0.887
DwilGK10799	DwilGK21971	B4NRD7	B4MQZ7	Zf-rbx1 domain-containing protein.	GK21971; Belongs to the cullin family.	0.983
DwilGK10799	DwilGK22408	B4NRD7	B4NG64	Zf-rbx1 domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.887
DwilGK10799	DwilGK23055	B4NRD7	B4NMP0	Zf-rbx1 domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.887
DwilGK10799	DwilGK23721	B4NRD7	B4MU43	Zf-rbx1 domain-containing protein.	Serine/threonine-protein phosphatase.	0.427
DwilGK10799	DwilGK24159	B4NRD7	B4N0Z0	Zf-rbx1 domain-containing protein.	Uncharacterized protein.	0.402