(19 nodes) Mixed, incl. Retromer complex, and WASH complex network (Drosophila guanche)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DGUA_6G011543	Blast:Vacuolar protein sorting-associated protein 26. (512 aa)
	DGUA_6G012727	Blast:WASH complex subunit CCDC53 homolog. (175 aa)
	DGUA_6G012689	Sorting nexin; Involved in several stages of intracellular trafficking. (447 aa)
	DGUA_6G002849	Blast:WAS protein family homolog 1. (489 aa)
	DGUA_6G006084	Blast:Cation-independent mannose-6-phosphate receptor. (932 aa)
	DGUA_6G001379	Blast:WASH complex subunit FAM21 homolog. (1285 aa)
	DGUA_6G002834	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (825 aa)
	DGUA_6G003483	Blast:Heat shock factor protein. (707 aa)
	DGUA_6G009314	Blast:WASH complex subunit strumpellin homolog. (1233 aa)
	DGUA_6G007801	Sorting nexin; Belongs to the sorting nexin family. (561 aa)
	DGUA_6G012748	Blast:Sorting nexin-2. (456 aa)
	DGUA_6G017271	Blast:Sorting nexin-12. (167 aa)
	DGUA_6G012841	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa)
	DGUA_6G011686	Blast:Heat shock factor-binding protein 1. (86 aa)
	DGUA_6G004146	Blast:Sorting nexin-17. (484 aa)
	DGUA_6G015683	Blast:Protein suppressor of variegation 3-7. (668 aa)
	DGUA_6G019474	Blast:Sorting nexin-27. (514 aa)
	DGUA_6G008824	Blast:WASH complex subunit 7 homolog. (1108 aa)
	DGUA_6G009128	Blast:von Willebrand factor A domain-containing protein 8. (1394 aa)

Your Current Organism:

Drosophila guanche

NCBI taxonomy Id: 7266
Other names: D. guanche

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DGUA_6G001379	DGUA_6G002834	A0A3B0JMI3	A0A3B0JNF5	Blast:WASH complex subunit FAM21 homolog.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.747
DGUA_6G001379	DGUA_6G002849	A0A3B0JMI3	A0A3B0JI84	Blast:WASH complex subunit FAM21 homolog.	Blast:WAS protein family homolog 1.	0.892
DGUA_6G001379	DGUA_6G008824	A0A3B0JMI3	A0A3B0KN80	Blast:WASH complex subunit FAM21 homolog.	Blast:WASH complex subunit 7 homolog.	0.792
DGUA_6G001379	DGUA_6G009128	A0A3B0JMI3	A0A3B0KNW3	Blast:WASH complex subunit FAM21 homolog.	Blast:von Willebrand factor A domain-containing protein 8.	0.411
DGUA_6G001379	DGUA_6G009314	A0A3B0JMI3	A0A3B0K0Z1	Blast:WASH complex subunit FAM21 homolog.	Blast:WASH complex subunit strumpellin homolog.	0.851
DGUA_6G001379	DGUA_6G011543	A0A3B0JMI3	A0A3B0JA31	Blast:WASH complex subunit FAM21 homolog.	Blast:Vacuolar protein sorting-associated protein 26.	0.592
DGUA_6G001379	DGUA_6G012727	A0A3B0JMI3	A0A3B0JBT1	Blast:WASH complex subunit FAM21 homolog.	Blast:WASH complex subunit CCDC53 homolog.	0.856
DGUA_6G001379	DGUA_6G012748	A0A3B0JMI3	A0A3B0K2K4	Blast:WASH complex subunit FAM21 homolog.	Blast:Sorting nexin-2.	0.571
DGUA_6G001379	DGUA_6G012841	A0A3B0JMI3	A0A3B0K4P5	Blast:WASH complex subunit FAM21 homolog.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.746
DGUA_6G001379	DGUA_6G015683	A0A3B0JMI3	A0A3B0KHH7	Blast:WASH complex subunit FAM21 homolog.	Blast:Protein suppressor of variegation 3-7.	0.476
DGUA_6G001379	DGUA_6G017271	A0A3B0JMI3	A0A3B0K3P0	Blast:WASH complex subunit FAM21 homolog.	Blast:Sorting nexin-12.	0.442
DGUA_6G001379	DGUA_6G019474	A0A3B0JMI3	A0A3B0KKW3	Blast:WASH complex subunit FAM21 homolog.	Blast:Sorting nexin-27.	0.580
DGUA_6G002834	DGUA_6G001379	A0A3B0JNF5	A0A3B0JMI3	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Blast:WASH complex subunit FAM21 homolog.	0.747
DGUA_6G002834	DGUA_6G002849	A0A3B0JNF5	A0A3B0JI84	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Blast:WAS protein family homolog 1.	0.524
DGUA_6G002834	DGUA_6G004146	A0A3B0JNF5	A0A3B0KBV6	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Blast:Sorting nexin-17.	0.637
DGUA_6G002834	DGUA_6G007801	A0A3B0JNF5	A0A3B0K193	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Sorting nexin; Belongs to the sorting nexin family.	0.652
DGUA_6G002834	DGUA_6G008824	A0A3B0JNF5	A0A3B0KN80	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Blast:WASH complex subunit 7 homolog.	0.442
DGUA_6G002834	DGUA_6G009128	A0A3B0JNF5	A0A3B0KNW3	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Blast:von Willebrand factor A domain-containing protein 8.	0.984
DGUA_6G002834	DGUA_6G009314	A0A3B0JNF5	A0A3B0K0Z1	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Blast:WASH complex subunit strumpellin homolog.	0.551
DGUA_6G002834	DGUA_6G011543	A0A3B0JNF5	A0A3B0JA31	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	Blast:Vacuolar protein sorting-associated protein 26.	0.996