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DGUA_6G000409 DGUA_6G000409 DGUA_6G001456 DGUA_6G001456 DGUA_6G001687 DGUA_6G001687 DGUA_6G000452 DGUA_6G000452 DGUA_6G002204 DGUA_6G002204 DGUA_6G007528 DGUA_6G007528 DGUA_6G002888 DGUA_6G002888 DGUA_6G010173 DGUA_6G010173 DGUA_6G010234 DGUA_6G010234 DGUA_6G008030 DGUA_6G008030 DGUA_6G006619 DGUA_6G006619 DGUA_6G007544 DGUA_6G007544 DGUA_6G010172 DGUA_6G010172 DGUA_6G000694 DGUA_6G000694 DGUA_6G000840 DGUA_6G000840 DGUA_6G006036 DGUA_6G006036 DGUA_6G012289 DGUA_6G012289 DGUA_6G006331 DGUA_6G006331 DGUA_6G013280 DGUA_6G013280 DGUA_6G000092 DGUA_6G000092 DGUA_6G004936 DGUA_6G004936 DGUA_6G013998 DGUA_6G013998 DGUA_6G014063 DGUA_6G014063 DGUA_6G014131 DGUA_6G014131 DGUA_6G005098 DGUA_6G005098 DGUA_6G014136 DGUA_6G014136 DGUA_6G014019 DGUA_6G014019 DGUA_6G014187 DGUA_6G014187 DGUA_6G001130 DGUA_6G001130 DGUA_6G017385 DGUA_6G017385 DGUA_6G017766 DGUA_6G017766 DGUA_6G001774 DGUA_6G001774 DGUA_6G013046 DGUA_6G013046 DGUA_6G001245 DGUA_6G001245 DGUA_6G014130 DGUA_6G014130 DGUA_6G017630 DGUA_6G017630 DGUA_6G000897 DGUA_6G000897 DGUA_6G017061 DGUA_6G017061 DGUA_6G017099 DGUA_6G017099 DGUA_6G003799 DGUA_6G003799 DGUA_6G001273 DGUA_6G001273 DGUA_6G006837 DGUA_6G006837 DGUA_6G017819 DGUA_6G017819 DGUA_6G016493 DGUA_6G016493 DGUA_6G015100 DGUA_6G015100 DGUA_6G006660 DGUA_6G006660 DGUA_6G004669 DGUA_6G004669 DGUA_6G004668 DGUA_6G004668 DGUA_6G002775 DGUA_6G002775 DGUA_6G012404 DGUA_6G012404 DGUA_6G010336 DGUA_6G010336 DGUA_6G008972 DGUA_6G008972 DGUA_6G004667 DGUA_6G004667 DGUA_6G009411 DGUA_6G009411 DGUA_6G012120 DGUA_6G012120 DGUA_6G007293 DGUA_6G007293 DGUA_6G012128 DGUA_6G012128 DGUA_6G011526 DGUA_6G011526 DGUA_6G009656 DGUA_6G009656 DGUA_6G009691 DGUA_6G009691 DGUA_6G019836 DGUA_6G019836 DGUA_6G013976 DGUA_6G013976 DGUA_6G012902 DGUA_6G012902 DGUA_6G018704 DGUA_6G018704 DGUA_6G015816 DGUA_6G015816 DGUA_6G018322 DGUA_6G018322 DGUA_6G018343 DGUA_6G018343 DGUA_6G020569 DGUA_6G020569 DGUA_6G016815 DGUA_6G016815 DGUA_6G006262 DGUA_6G006262 DGUA_6G019333 DGUA_6G019333 DGUA_6G019463 DGUA_6G019463 DGUA_6G014188 DGUA_6G014188 DGUA_6G017669 DGUA_6G017669 DGUA_6G017688 DGUA_6G017688 DGUA_6G005824 DGUA_6G005824 DGUA_6M05 DGUA_6M05 DGUA_6M39 DGUA_6M39 DGUA_6G016333 DGUA_6G016333 DGUA_6G004539 DGUA_6G004539 DGUA_6G004739 DGUA_6G004739 DGUA_6G016304 DGUA_6G016304 DGUA_6G017017 DGUA_6G017017 DGUA_6G013635 DGUA_6G013635 DGUA_6G014963 DGUA_6G014963 DGUA_6G017098 DGUA_6G017098 DGUA_6G014301 DGUA_6G014301 DGUA_6G016421 DGUA_6G016421 DGUA_6G017388 DGUA_6G017388 DGUA_6G014775 DGUA_6G014775 DGUA_6G018341 DGUA_6G018341 DGUA_6G008840 DGUA_6G008840 DGUA_6G004300 DGUA_6G004300 DGUA_6G008849 DGUA_6G008849 DGUA_6G014471 DGUA_6G014471 DGUA_6G009444 DGUA_6G009444 DGUA_6M02 DGUA_6M02 DGUA_6G019990 DGUA_6G019990 DGUA_6G015423 DGUA_6G015423 DGUA_6G015812 DGUA_6G015812 DGUA_6G019112 DGUA_6G019112 DGUA_6G020607 DGUA_6G020607 DGUA_6G009743 DGUA_6G009743 DGUA_6M01 DGUA_6M01 DGUA_6M28 DGUA_6M28 DGUA_6G019220 DGUA_6G019220 DGUA_6G020523 DGUA_6G020523 DGUA_6M04 DGUA_6M04 DGUA_6M27 DGUA_6M27
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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DGUA_6G000409Blast:Cytochrome c oxidase subunit 6A1, mitochondrial; Belongs to the cytochrome c oxidase subunit 6A family. (109 aa)
DGUA_6G001456NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
DGUA_6G001687Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (157 aa)
DGUA_6G000452Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (297 aa)
DGUA_6G002204Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (604 aa)
DGUA_6G007528Blast:Ubiquitin-conjugating enzyme E2 variant 1. (307 aa)
DGUA_6G002888Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (661 aa)
DGUA_6G010173Blast:Fumarate hydratase, mitochondrial. (496 aa)
DGUA_6G010234Citrate synthase; Belongs to the citrate synthase family. (521 aa)
DGUA_6G008030Blast:Probable isocitrate dehydrogenase. (750 aa)
DGUA_6G006619Blast:Probable fumarate hydratase, mitochondrial. (469 aa)
DGUA_6G007544Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (422 aa)
DGUA_6G010172Blast:Fumarate hydratase, mitochondrial. (493 aa)
DGUA_6G000694Malate dehydrogenase. (350 aa)
DGUA_6G000840Blast:Probable isocitrate dehydrogenase. (422 aa)
DGUA_6G006036NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (408 aa)
DGUA_6G012289Blast:UPF0369 protein C6orf57 homolog. (119 aa)
DGUA_6G006331Blast:Cytochrome c1, heme protein, mitochondrial. (347 aa)
DGUA_6G013280Malate dehydrogenase. (337 aa)
DGUA_6G000092Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (726 aa)
DGUA_6G004936Blast:Neutral ceramidase; Belongs to the mitochondrial carrier (TC 2.A.29) family. (689 aa)
DGUA_6G013998Blast:Cytochrome c oxidase assembly protein COX11, mitochondrial. (245 aa)
DGUA_6G014063NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (126 aa)
DGUA_6G014131Blast:Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
DGUA_6G005098Blast:Cytochrome c oxidase subunit 4 isoform 1, mitochondrial. (183 aa)
DGUA_6G014136Blast:Solute carrier family 25 member 36; Belongs to the mitochondrial carrier (TC 2.A.29) family. (366 aa)
DGUA_6G014019NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (118 aa)
DGUA_6G014187Blast:Cytochrome c oxidase subunit 5B, mitochondrial. (153 aa)
DGUA_6G001130Blast:Cytochrome c oxidase subunit 7C, mitochondrial. (82 aa)
DGUA_6G017385Blast:Probable cytochrome c oxidase subunit 7A, mitochondrial. (100 aa)
DGUA_6G017766Blast:Cytoplasmic aconitate hydratase. (789 aa)
DGUA_6G001774Blast:Coenzyme Q-binding protein COQ10, mitochondrial. (262 aa)
DGUA_6G013046Blast:LYR motif-containing protein 5; Belongs to the complex I LYR family. (85 aa)
DGUA_6G001245Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (158 aa)
DGUA_6G014130Blast:Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
DGUA_6G017630Blast:NADH dehydrogenase; Belongs to the complex I 20 kDa subunit family. (222 aa)
DGUA_6G000897Blast:Probable isocitrate dehydrogenase. (390 aa)
DGUA_6G017061Citrate synthase; Belongs to the citrate synthase family. (506 aa)
DGUA_6G017099Blast:Mitochondrial glutamate carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
DGUA_6G003799Blast:NADH dehydrogenase. (498 aa)
DGUA_6G001273Blast:Putative ATP synthase subunit f, mitochondrial. (107 aa)
DGUA_6G006837Uncharacterized protein. (146 aa)
DGUA_6G017819Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (184 aa)
DGUA_6G016493Blast:NADH dehydrogenase; Belongs to the complex I 49 kDa subunit family. (517 aa)
DGUA_6G015100Blast:2-oxoglutarate dehydrogenase, mitochondrial. (1018 aa)
DGUA_6G006660Malate dehydrogenase. (339 aa)
DGUA_6G004669Blast:Cytochrome c oxidase subunit 6A1, mitochondrial; Belongs to the cytochrome c oxidase subunit 6A family. (296 aa)
DGUA_6G004668Blast:Cytochrome c oxidase subunit 6A1, mitochondrial; Belongs to the cytochrome c oxidase subunit 6A family. (273 aa)
DGUA_6G002775Blast:NADH dehydrogenase. (634 aa)
DGUA_6G012404Blast:Cytochrome c oxidase subunit 6C. (80 aa)
DGUA_6G010336Blast:NADH dehydrogenase. (102 aa)
DGUA_6G008972Blast:Cytochrome c oxidase assembly factor 6 homolog. (92 aa)
DGUA_6G004667COX6C domain-containing protein. (84 aa)
DGUA_6G009411Blast:Putative methyltransferase NSUN7. (719 aa)
DGUA_6G012120Uncharacterized protein. (62 aa)
DGUA_6G007293Blast:2-oxoglutarate dehydrogenase, mitochondrial. (1150 aa)
DGUA_6G012128Blast:Putative apoptosis-inducing factor 1, mitochondrial. (690 aa)
DGUA_6G011526Blast:NADH dehydrogenase. (175 aa)
DGUA_6G009656Blast:Probable NADH dehydrogenase. (240 aa)
DGUA_6G009691Blast:Cytochrome b-c1 complex subunit 8. (89 aa)
DGUA_6G019836Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (85 aa)
DGUA_6G013976Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (788 aa)
DGUA_6G012902Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (230 aa)
DGUA_6G018704Uncharacterized protein. (71 aa)
DGUA_6G015816Uncharacterized protein. (143 aa)
DGUA_6G018322Blast:Succinate dehydrogenase cytochrome b560 subunit, mitochondrial. (152 aa)
DGUA_6G018343Blast:Succinate dehydrogenase cytochrome b560 subunit, mitochondrial. (248 aa)
DGUA_6G020569Blast:Cyclic nucleotide-binding domain-containing protein 2. (274 aa)
DGUA_6G016815Blast:NADH dehydrogenase. (217 aa)
DGUA_6G006262Blast:Complex III assembly factor LYRM7; Belongs to the complex I LYR family. (137 aa)
DGUA_6G019333Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (341 aa)
DGUA_6G019463Blast:NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family. (735 aa)
DGUA_6G014188Blast:Cytochrome c oxidase subunit 5B, mitochondrial. (120 aa)
DGUA_6G017669Blast:Probable complex I intermediate-associated protein 30, mitochondrial. (295 aa)
DGUA_6G017688Blast:Isocitrate dehydrogenase. (378 aa)
DGUA_6G005824Blast:Protein DJ-1. (214 aa)
DGUA_6M05Nad5-1. (481 aa)
DGUA_6M39Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (375 aa)
DGUA_6G016333Blast:Malate dehydrogenase, mitochondrial; Belongs to the LDH/MDH superfamily. (336 aa)
DGUA_6G004539Blast:Cytochrome c oxidase subunit 4 isoform 2, mitochondrial. (182 aa)
DGUA_6G004739NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (476 aa)
DGUA_6G016304Blast:Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate. (478 aa)
DGUA_6G017017Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (451 aa)
DGUA_6G013635NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (142 aa)
DGUA_6G014963Blast:Transmembrane protein 11 homolog, mitochondrial. (172 aa)
DGUA_6G017098Blast:Mitochondrial glutamate carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
DGUA_6G014301Uncharacterized protein. (165 aa)
DGUA_6G016421Blast:ATP synthase subunit O, mitochondrial. (210 aa)
DGUA_6G017388Blast:Probable cytochrome c oxidase subunit 7A, mitochondrial. (90 aa)
DGUA_6G014775Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (328 aa)
DGUA_6G018341Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (790 aa)
DGUA_6G008840Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
DGUA_6G004300Blast:NADH dehydrogenase. (144 aa)
DGUA_6G008849Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (354 aa)
DGUA_6G014471Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (641 aa)
DGUA_6G009444Blast:Cytochrome b-c1 complex subunit 2, mitochondrial. (441 aa)
DGUA_6M02Nad4-1_b. (107 aa)
DGUA_6G019990Blast:Cytochrome c oxidase subunit 5A, mitochondrial. (149 aa)
DGUA_6G015423Blast:Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (900 aa)
DGUA_6G015812Blast:Glucosidase 2 subunit beta. (558 aa)
DGUA_6G019112ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (506 aa)
DGUA_6G020607Blast:NADH dehydrogenase. (257 aa)
DGUA_6G009743Uncharacterized protein. (51 aa)
DGUA_6M01Nad4-1_a. (97 aa)
DGUA_6M28Nad2-1. (36 aa)
DGUA_6G019220Blast:Transcriptional activator protein Pur-beta; Belongs to the complex I 49 kDa subunit family. (473 aa)
DGUA_6G020523Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (354 aa)
DGUA_6M04NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (419 aa)
DGUA_6M27NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (158 aa)
Your Current Organism:
Drosophila guanche
NCBI taxonomy Id: 7266
Other names: D. guanche
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