23 items (Drosophila guanche) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	DGUA_6G002750	Blast:Phosphoenolpyruvate carboxykinase. (647 aa)
	DGUA_6G016363	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (158 aa)
	DGUA_6G014087	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (140 aa)
	DGUA_6G007786	4-hydroxyphenylpyruvate dioxygenase. (380 aa)
	DGUA_6G011115	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. (264 aa)
	DGUA_6G002749	Blast:Phosphoenolpyruvate carboxykinase. (639 aa)
	DGUA_6G002711	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1197 aa)
	DGUA_6G019485	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (526 aa)
	DGUA_6G020098	Serine--pyruvate aminotransferase. (395 aa)
	DGUA_6G020085	Blast:Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial. (941 aa)
	DGUA_6G019484	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (399 aa)
	DGUA_6G016366	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (148 aa)
	DGUA_6G017468	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. (446 aa)
	DGUA_6G013318	S-adenosylmethionine decarboxylase proenzyme. (354 aa)
	DGUA_6G012483	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (363 aa)
	DGUA_6G011794	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (408 aa)
	DGUA_6G005489	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (365 aa)
	DGUA_6G012475	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
	DGUA_6G017359	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (107 aa)
	DGUA_6G014293	Pyruvate kinase; Belongs to the pyruvate kinase family. (554 aa)
	DGUA_6G017957	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (348 aa)
	DGUA_6G013795	Blast:Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase. (512 aa)
	DGUA_6G015475	Pyruvate kinase; Belongs to the pyruvate kinase family. (1152 aa)

Your Current Organism:

Drosophila guanche

NCBI taxonomy Id: 7266
Other names: D. guanche

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DGUA_6G002711	DGUA_6G002749	A0A3B0J1E1	A0A3B0J1F3	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Blast:Phosphoenolpyruvate carboxykinase.	0.948
DGUA_6G002711	DGUA_6G002750	A0A3B0J1E1	A0A3B0JNW7	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Blast:Phosphoenolpyruvate carboxykinase.	0.948
DGUA_6G002711	DGUA_6G005489	A0A3B0J1E1	A0A3B0K6H8	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.954
DGUA_6G002711	DGUA_6G007786	A0A3B0J1E1	A0A3B0JAW4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	4-hydroxyphenylpyruvate dioxygenase.	0.810
DGUA_6G002711	DGUA_6G011794	A0A3B0J1E1	A0A3B0JU78	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.925
DGUA_6G002711	DGUA_6G012475	A0A3B0J1E1	A0A3B0K7V0	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.538
DGUA_6G002711	DGUA_6G012483	A0A3B0J1E1	A0A3B0K0W2	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.538
DGUA_6G002711	DGUA_6G013795	A0A3B0J1E1	A0A3B0KEJ2	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Blast:Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase.	0.957
DGUA_6G002711	DGUA_6G014293	A0A3B0J1E1	A0A3B0KBJ3	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.945
DGUA_6G002711	DGUA_6G015475	A0A3B0J1E1	A0A3B0KH19	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.945
DGUA_6G002711	DGUA_6G017957	A0A3B0J1E1	A0A3B0KDQ3	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.538
DGUA_6G002711	DGUA_6G019484	A0A3B0J1E1	A0A3B0KTT8	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.932
DGUA_6G002711	DGUA_6G019485	A0A3B0J1E1	A0A3B0K4S1	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.932
DGUA_6G002749	DGUA_6G002711	A0A3B0J1F3	A0A3B0J1E1	Blast:Phosphoenolpyruvate carboxykinase.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.948
DGUA_6G002749	DGUA_6G002750	A0A3B0J1F3	A0A3B0JNW7	Blast:Phosphoenolpyruvate carboxykinase.	Blast:Phosphoenolpyruvate carboxykinase.	0.899
DGUA_6G002749	DGUA_6G005489	A0A3B0J1F3	A0A3B0K6H8	Blast:Phosphoenolpyruvate carboxykinase.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.925
DGUA_6G002749	DGUA_6G011794	A0A3B0J1F3	A0A3B0JU78	Blast:Phosphoenolpyruvate carboxykinase.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.810
DGUA_6G002749	DGUA_6G012475	A0A3B0J1F3	A0A3B0K7V0	Blast:Phosphoenolpyruvate carboxykinase.	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.420
DGUA_6G002749	DGUA_6G012483	A0A3B0J1F3	A0A3B0K0W2	Blast:Phosphoenolpyruvate carboxykinase.	Blast:Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.422
DGUA_6G002749	DGUA_6G013795	A0A3B0J1F3	A0A3B0KEJ2	Blast:Phosphoenolpyruvate carboxykinase.	Blast:Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase.	0.923