STRINGSTRING
cyaY_2 cyaY_2 nsrR nsrR hmp hmp hemG hemG nfuA nfuA fdx fdx hscA hscA hscB hscB iscA iscA nifU nifU iscS iscS iscR iscR KKB00297.1 KKB00297.1 KKB00298.1 KKB00298.1 KKB00299.1 KKB00299.1 KKB00300.1 KKB00300.1 KKB00334.1 KKB00334.1 KKB00335.1 KKB00335.1 djlA djlA dusC dusC bolA bolA hemE hemE hemN_2 hemN_2 crcB crcB cof cof fis fis dus_3 dus_3 hemC hemC ubiF_2 ubiF_2 ubiH ubiH pepP pepP KKA99765.1 KKA99765.1 zapA zapA KKA99767.1 KKA99767.1 tsaA tsaA rraA rraA KKA99774.1 KKA99774.1 ubiE ubiE KKA99776.1 KKA99776.1 ubiB ubiB tatA tatA tatB tatB tatC tatC hemB hemB yjjV yjjV ubiD ubiD minD minD ubiF ubiF miaB miaB hemA hemA pad1 pad1 grxD grxD KKA99218.1 KKA99218.1 KKA99219.1 KKA99219.1 KKA99220.1 KKA99220.1 hemH hemH ubiG ubiG KKA98579.1 KKA98579.1 lipB lipB lipA lipA ftsP ftsP hemL hemL hemN_1 hemN_1 dusA dusA ubiA ubiA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cyaY_2Frataxin; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (102 aa)
nsrRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
hmpDihydropteridine reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the globin family. (399 aa)
hemGProtoporphyrinogen oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
nfuAAmino acid ABC transporter substrate-binding protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (194 aa)
fdx2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
hscAChaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (621 aa)
hscBCo-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (172 aa)
iscAIron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. (107 aa)
nifUScaffolding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (127 aa)
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa)
iscRTranscriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (156 aa)
KKB00297.1tRNA (cytidine/uridine-2'-O-)-methyltransferase; Catalyzes the fromation of 2'O-methylated cytidine or 2'O-methylated uridine at position 32 in tRNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
KKB00298.1Inositol monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily. (268 aa)
KKB00299.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
KKB00300.1Peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
KKB00334.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (286 aa)
KKB00335.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
djlAMolecular chaperone DnaJ; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. (286 aa)
dusCtRNA-dihydrouridine synthase C; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (312 aa)
bolABolA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BolA/IbaG family. (103 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
hemN_2Coproporphyrinogen III oxidase; Catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (455 aa)
crcBChromosome condensation protein CrcB; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (127 aa)
cofMembrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
fisFis family transcriptional regulator; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (99 aa)
dus_3tRNA-dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (332 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa)
ubiF_2Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
ubiH2-octaprenyl-6-methoxyphenyl hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
pepPProline aminopeptidase P II; Exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
KKA99765.1Hypothetical protein; The crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0149 family. (183 aa)
zapACell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (100 aa)
KKA99767.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (191 aa)
tsaAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
rraARegulator of ribonuclease activity A; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. (165 aa)
KKA99774.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
ubiEUbiquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (263 aa)
KKA99776.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
ubiBUbiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (545 aa)
tatAPreprotein translocase subunit TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (75 aa)
tatBPreprotein translocase subunit TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (190 aa)
tatCTwin-arginine protein translocation system subunit TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (259 aa)
hemBDelta-aminolevulinic acid dehydratase; Catalyzes the formation of porphobilinogen from 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (337 aa)
yjjVDeoxyribonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
ubiD3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (490 aa)
minDSodium:proton antiporter; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (374 aa)
ubiF2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
miaB(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (474 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (434 aa)
pad13-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (196 aa)
grxDGlutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaredoxin family. Monothiol subfamily. (112 aa)
KKA99218.1Methanol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
KKA99219.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
KKA99220.1LemA family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (323 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (237 aa)
KKA98579.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0250 family. (100 aa)
lipBLipoate--protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (217 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (320 aa)
ftsPCell division protein FtsQ; Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress; Belongs to the FtsP family. (469 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
hemN_1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (384 aa)
dusAtRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (332 aa)
ubiA4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (287 aa)
Your Current Organism:
Avibacterium paragallinarum
NCBI taxonomy Id: 728
Other names: A. paragallinarum, ATCC 29545, CCUG 12835, CIP 103453, DSM 18554, Haemophilus gallinarum, Haemophilus paragallinarum, NCTC 11296
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