STRINGSTRING
ftsL ftsL yhcM yhcM murA murA tolB tolB ybgF ybgF ftsK ftsK tig tig zapC zapC GCA_000819825_02835 GCA_000819825_02835 damX_2 damX_2 zipA zipA murB murB ftsN ftsN slmA slmA GCA_000819825_03723 GCA_000819825_03723 minC minC minD_1 minD_1 GCA_000819825_00408 GCA_000819825_00408 GCA_000819825_00441 GCA_000819825_00441 ftsE ftsE ftsX ftsX xerC_1 xerC_1 GCA_000819825_00913 GCA_000819825_00913 mukB mukB mukE mukE mukF mukF GCA_000819825_01112 GCA_000819825_01112 nlpI nlpI zapA zapA dedD dedD damX_1 damX_1 tapM tapM GCA_000819825_01570 GCA_000819825_01570 mrdB_2 mrdB_2 mrdB_1 mrdB_1 envC envC engB engB mpl mpl nlpD_1 nlpD_1 ftsB ftsB zapD zapD ftsZ ftsZ ftsA ftsA ftsQ ftsQ murC murC murG murG ftsW ftsW murD murD mraY mraY murF murF murE murE ftsI ftsI minE minE scpB scpB zapB zapB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ftsLUnannotated protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (104 aa)
yhcMUnannotated protein; Reduces the stability of FtsZ polymers in the presence of ATP. (364 aa)
murAUnannotated protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa)
tolBUnannotated protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (441 aa)
ybgFUnannotated protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (266 aa)
ftsKUnannotated protein. (833 aa)
tigUnannotated protein; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (436 aa)
zapCUnannotated protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (178 aa)
GCA_000819825_02835Unannotated protein. (1092 aa)
damX_2Unannotated protein. (269 aa)
zipAUnannotated protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (370 aa)
murBUnannotated protein; Cell wall formation. (345 aa)
ftsNUnannotated protein. (269 aa)
slmAUnannotated protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (198 aa)
GCA_000819825_03723Unannotated protein. (62 aa)
minCUnannotated protein; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (238 aa)
minD_1Unannotated protein. (270 aa)
GCA_000819825_00408Unannotated protein. (301 aa)
GCA_000819825_00441Unannotated protein. (222 aa)
ftsEUnannotated protein; Part of the ABC transporter FtsEX involved in cellular division. (223 aa)
ftsXUnannotated protein; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (317 aa)
xerC_1Unannotated protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (318 aa)
GCA_000819825_00913Unannotated protein. (183 aa)
mukBUnannotated protein. (1480 aa)
mukEUnannotated protein. (245 aa)
mukFUnannotated protein; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. (439 aa)
GCA_000819825_01112Unannotated protein. (162 aa)
nlpIUnannotated protein; May be involved in cell division. (314 aa)
zapAUnannotated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (110 aa)
dedDUnannotated protein. (255 aa)
damX_1Unannotated protein. (517 aa)
tapMUnannotated protein. (353 aa)
GCA_000819825_01570Unannotated protein. (275 aa)
mrdB_2Unannotated protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (367 aa)
mrdB_1Unannotated protein. (45 aa)
envCUnannotated protein. (467 aa)
engBUnannotated protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (205 aa)
mplUnannotated protein; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (454 aa)
nlpD_1Unannotated protein. (348 aa)
ftsBUnannotated protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (105 aa)
zapDUnannotated protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (240 aa)
ftsZUnannotated protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
ftsAUnannotated protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (419 aa)
ftsQUnannotated protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (250 aa)
murCUnannotated protein; Cell wall formation; Belongs to the MurCDEF family. (484 aa)
murGUnannotated protein; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa)
ftsWUnannotated protein; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (394 aa)
murDUnannotated protein; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (427 aa)
mraYUnannotated protein; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murFUnannotated protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (451 aa)
murEUnannotated protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (494 aa)
ftsIUnannotated protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (584 aa)
minEUnannotated protein; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (88 aa)
scpBUnannotated protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (189 aa)
zapBUnannotated protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (69 aa)
Your Current Organism:
Aeromonas encheleia
NCBI taxonomy Id: 73010
Other names: A. encheleia, ATCC 51929, Aeromonas eucrenophila subgroup II, Aeromonas sp. DSM 11577, Aeromonas sp. HG11, CECT 4342, CIP 104608, DSM 11577, LMG 16330, LMG:16330, NCTC 12917, strain S181, ten Aeromonas encheleia-like isolates
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