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| | D0Z67_14845 | Unannotated protein. (485 aa) |
| | gyrA | Unannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (873 aa) |
| | gyrB | Unannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (688 aa) |
| | recF | Unannotated protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (373 aa) |
| | D0Z67_14620 | Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...] (376 aa) |
| | dnaA | Unannotated protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (641 aa) |
| | rsmG | Unannotated protein; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (238 aa) |
| | D0Z67_14570 | Unannotated protein. (341 aa) |
| | D0Z67_14565 | Unannotated protein; Belongs to the ParB family. (364 aa) |
| | ssb | Unannotated protein. (196 aa) |
| | dnaB | Unannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (492 aa) |
| | D0Z67_14350 | Unannotated protein. (357 aa) |
| | D0Z67_14165 | Unannotated protein. (284 aa) |
| | dnaX | Unannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (737 aa) |
| | holA | Unannotated protein. (329 aa) |
| | dnaG | Unannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (634 aa) |
| | D0Z67_08235 | Unannotated protein. (368 aa) |
| | D0Z67_08230 | Unannotated protein. (288 aa) |
| | D0Z67_08225 | Unannotated protein. (196 aa) |
| | D0Z67_08220 | Unannotated protein. (418 aa) |
| | nfo | Unannotated protein; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (300 aa) |
| | D0Z67_05290 | Unannotated protein. (737 aa) |
| | D0Z67_05285 | Unannotated protein. (327 aa) |
| | D0Z67_05275 | Unannotated protein. (262 aa) |
| | D0Z67_05025 | Unannotated protein. (301 aa) |
| | D0Z67_04555 | Unannotated protein. (241 aa) |
| | priA | Unannotated protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (715 aa) |
| | xth | Unannotated protein. (274 aa) |
| | mfd | Unannotated protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1181 aa) |
| | D0Z67_11265 | Unannotated protein. (339 aa) |
| | ung | Unannotated protein; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa) |
| | D0Z67_02055 | Unannotated protein. (871 aa) |
| | rnhA | Unannotated protein; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (233 aa) |
| | pcrA | Unannotated protein. (826 aa) |
| | xseB | Unannotated protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (74 aa) |
| | xseA | Unannotated protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (406 aa) |
| | D0Z67_19330 | Unannotated protein; Belongs to the helicase family. UvrD subfamily. (1115 aa) |
| | D0Z67_19335 | Unannotated protein; Belongs to the helicase family. UvrD subfamily. (1137 aa) |
| | D0Z67_19355 | Unannotated protein. (722 aa) |
| | D0Z67_19895 | Unannotated protein. (293 aa) |
| | ku | Unannotated protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (351 aa) |
| | D0Z67_20335 | Unannotated protein. (468 aa) |
| | D0Z67_26165 | Unannotated protein; Belongs to the FPG family. (287 aa) |
| | D0Z67_25395 | Unannotated protein. (567 aa) |
| | uvrB | Unannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the [...] (640 aa) |
| | D0Z67_23215 | Unannotated protein. (241 aa) |
| | ligA | Unannotated protein; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (731 aa) |
| | mutM | Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (286 aa) |
| | smc | Unannotated protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1314 aa) |
| | lig | Unannotated protein; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (512 aa) |
| | D0Z67_03365 | Unannotated protein. (162 aa) |
| | D0Z67_03455 | Unannotated protein. (997 aa) |
| | sbcD | Unannotated protein; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (387 aa) |
| | ung-2 | Unannotated protein; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa) |
| | dinB | Unannotated protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (466 aa) |
| | D0Z67_06075 | Unannotated protein. (327 aa) |
| | D0Z67_09555 | Unannotated protein; Belongs to the FPG family. (269 aa) |
| | D0Z67_09795 | Unannotated protein. (156 aa) |
| | D0Z67_23380 | Unannotated protein. (480 aa) |
| | D0Z67_23385 | Unannotated protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (167 aa) |
| | xth-2 | Unannotated protein. (259 aa) |
| | nth | Unannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (285 aa) |
| | topA | Unannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (943 aa) |
| | D0Z67_16000 | Unannotated protein. (401 aa) |
| | disA | Unannotated protein; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. (374 aa) |
| | radA | Unannotated protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (469 aa) |
| | uvrC | Unannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (699 aa) |
| | uvrA | Unannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1001 aa) |
| | uvrB-2 | Unannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the [...] (715 aa) |
| | D0Z67_06765 | Unannotated protein. (232 aa) |
| | polA | Unannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (888 aa) |
| | D0Z67_07100 | Unannotated protein. (527 aa) |
| | D0Z67_07140 | Unannotated protein. (1179 aa) |
| | D0Z67_29435 | Unannotated protein; Belongs to the ParB family. (380 aa) |
| | D0Z67_29440 | Unannotated protein. (220 aa) |
| | D0Z67_21705 | Unannotated protein; Belongs to the FtsK/SpoIIIE/SftA family. (915 aa) |
| | recA | Unannotated protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (373 aa) |
| | recX | Unannotated protein; Modulates RecA activity; Belongs to the RecX family. (263 aa) |
| | recQ | Unannotated protein. (664 aa) |
| | D0Z67_05615 | Unannotated protein. (284 aa) |
| | D0Z67_05620 | Unannotated protein. (326 aa) |
| | dnaE | Unannotated protein; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (883 aa) |
| | der | Unannotated protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (494 aa) |
| | cmk | Unannotated protein. (231 aa) |
| | D0Z67_05715 | Unannotated protein. (340 aa) |
| | D0Z67_05720 | Unannotated protein; Belongs to the pseudouridine synthase RsuA family. (353 aa) |
| | scpB | Unannotated protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (229 aa) |
| | D0Z67_05730 | Unannotated protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (318 aa) |
| | D0Z67_05735 | Unannotated protein. (182 aa) |
| | D0Z67_05740 | Unannotated protein. (338 aa) |
| | D0Z67_00480 | Unannotated protein. (333 aa) |
| | D0Z67_22230 | Unannotated protein. (817 aa) |
| | lexA | Unannotated protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (258 aa) |
| | D0Z67_22060 | Unannotated protein. (201 aa) |
| | D0Z67_22065 | Unannotated protein; Belongs to the phosphoglycerate mutase family. (219 aa) |
| | D0Z67_22070 | Unannotated protein. (303 aa) |
| | rnhB | Unannotated protein; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (233 aa) |
| | D0Z67_22110 | Unannotated protein. (720 aa) |
| | D0Z67_22150 | Unannotated protein. (707 aa) |
| | D0Z67_24555 | Unannotated protein. (353 aa) |
| | D0Z67_24560 | Unannotated protein. (340 aa) |
| | D0Z67_23990 | Unannotated protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (169 aa) |
| | D0Z67_23985 | Unannotated protein. (502 aa) |
| | D0Z67_21300 | Unannotated protein. (788 aa) |
| | D0Z67_24275 | Unannotated protein. (220 aa) |
| | GCA_000725795_05843 | Unannotated protein. (442 aa) |
