STRINGSTRING
dxs dxs D0Z67_14425 D0Z67_14425 thiC thiC D0Z67_13700 D0Z67_13700 panD panD D0Z67_27295 D0Z67_27295 D0Z67_08410 D0Z67_08410 panB panB cobS cobS cobT cobT D0Z67_07720 D0Z67_07720 GCA_000725795_01113 GCA_000725795_01113 thiS thiS thiO thiO thiE thiE cbiE cbiE cobT-2 cobT-2 pdxS pdxS pdxT pdxT D0Z67_04150 D0Z67_04150 ribBA ribBA ribH ribH D0Z67_04120 D0Z67_04120 serC serC pdxH pdxH D0Z67_12485 D0Z67_12485 D0Z67_11890 D0Z67_11890 D0Z67_02430 D0Z67_02430 pdxH-2 pdxH-2 D0Z67_01690 D0Z67_01690 D0Z67_20070 D0Z67_20070 panD-2 panD-2 cobF cobF D0Z67_25295 D0Z67_25295 kbl kbl dxs-2 dxs-2 D0Z67_23075 D0Z67_23075 thiL thiL thiD thiD D0Z67_03085 D0Z67_03085 D0Z67_03175 D0Z67_03175 D0Z67_03295 D0Z67_03295 bioB bioB bioA bioA bioD bioD D0Z67_06235 D0Z67_06235 cobJ cobJ D0Z67_06225 D0Z67_06225 cobM cobM cobI cobI cobB-2 cobB-2 cobO cobO cobN cobN cobQ cobQ cobD cobD D0Z67_10140 D0Z67_10140 D0Z67_10525 D0Z67_10525 D0Z67_23350 D0Z67_23350 D0Z67_23355 D0Z67_23355 folK folK folB folB folP-2 folP-2 panC panC hemA-2 hemA-2 D0Z67_22300 D0Z67_22300 D0Z67_22225 D0Z67_22225 D0Z67_21515 D0Z67_21515 D0Z67_21260 D0Z67_21260 D0Z67_21295 D0Z67_21295 D0Z67_24230 D0Z67_24230 D0Z67_24345 D0Z67_24345 ribA ribA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dxsUnannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa)
D0Z67_14425Unannotated protein. (139 aa)
thiCUnannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (601 aa)
D0Z67_13700Unannotated protein. (377 aa)
panDUnannotated protein; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (135 aa)
D0Z67_27295Unannotated protein. (273 aa)
D0Z67_08410Unannotated protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (304 aa)
panBUnannotated protein; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (287 aa)
cobSUnannotated protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (266 aa)
cobTUnannotated protein; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (363 aa)
D0Z67_07720Unannotated protein. (399 aa)
GCA_000725795_01113Unannotated protein. (293 aa)
thiSUnannotated protein. (66 aa)
thiOUnannotated protein. (394 aa)
thiEUnannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (215 aa)
cbiEUnannotated protein. (405 aa)
cobT-2Unannotated protein; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1123 aa)
pdxSUnannotated protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (301 aa)
pdxTUnannotated protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa)
D0Z67_04150Unannotated protein. (201 aa)
ribBAUnannotated protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (439 aa)
ribHUnannotated protein; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (162 aa)
D0Z67_04120Unannotated protein. (156 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
pdxHUnannotated protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (230 aa)
D0Z67_12485Unannotated protein. (228 aa)
D0Z67_11890Unannotated protein. (350 aa)
D0Z67_02430Unannotated protein. (276 aa)
pdxH-2Unannotated protein. (212 aa)
D0Z67_01690Unannotated protein. (127 aa)
D0Z67_20070Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
panD-2Unannotated protein; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (139 aa)
cobFUnannotated protein. (233 aa)
D0Z67_25295Unannotated protein. (257 aa)
kblUnannotated protein; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (399 aa)
dxs-2Unannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (645 aa)
D0Z67_23075Unannotated protein. (264 aa)
thiLUnannotated protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (320 aa)
thiDUnannotated protein. (265 aa)
D0Z67_03085Unannotated protein. (115 aa)
D0Z67_03175Unannotated protein. (242 aa)
D0Z67_03295Unannotated protein. (376 aa)
bioBUnannotated protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (396 aa)
bioAUnannotated protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (425 aa)
bioDUnannotated protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa)
D0Z67_06235Unannotated protein. (195 aa)
cobJUnannotated protein. (563 aa)
D0Z67_06225Unannotated protein. (411 aa)
cobMUnannotated protein. (272 aa)
cobIUnannotated protein; Belongs to the precorrin methyltransferase family. (243 aa)
cobB-2Unannotated protein; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (529 aa)
cobOUnannotated protein. (199 aa)
cobNUnannotated protein. (1216 aa)
cobQUnannotated protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
cobDUnannotated protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (313 aa)
D0Z67_10140Unannotated protein. (477 aa)
D0Z67_10525Unannotated protein. (201 aa)
D0Z67_23350Unannotated protein. (416 aa)
D0Z67_23355Unannotated protein. (439 aa)
folKUnannotated protein. (203 aa)
folBUnannotated protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
folP-2Unannotated protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (306 aa)
panCUnannotated protein; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (333 aa)
hemA-2Unannotated protein. (420 aa)
D0Z67_22300Unannotated protein. (438 aa)
D0Z67_22225Unannotated protein. (352 aa)
D0Z67_21515Unannotated protein; Belongs to the ribF family. (315 aa)
D0Z67_21260Unannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
D0Z67_21295Unannotated protein. (136 aa)
D0Z67_24230Unannotated protein. (278 aa)
D0Z67_24345Unannotated protein. (258 aa)
ribAUnannotated protein; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (219 aa)
Your Current Organism:
Streptomyces seoulensis
NCBI taxonomy Id: 73044
Other names: CIP 105312, IFO 16255, IFO 16668, IMSNU 21266, JCM 10116, NBRC 16255, NBRC 16668, S. seoulensis, Streptomyces sp. USC028, Streptomyces sp. USC046, strain IMSNU-1
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