STRINGSTRING
D0Z67_14865 D0Z67_14865 gyrA gyrA gyrB gyrB dnaB dnaB D0Z67_13990 D0Z67_13990 D0Z67_08425 D0Z67_08425 D0Z67_05290 D0Z67_05290 ruvA ruvA ruvB ruvB D0Z67_04430 D0Z67_04430 priA priA D0Z67_03955 D0Z67_03955 D0Z67_13415 D0Z67_13415 D0Z67_12835 D0Z67_12835 D0Z67_12820 D0Z67_12820 D0Z67_11945 D0Z67_11945 D0Z67_11665 D0Z67_11665 mfd mfd D0Z67_17705 D0Z67_17705 pcrA pcrA D0Z67_19330 D0Z67_19330 D0Z67_19335 D0Z67_19335 D0Z67_19355 D0Z67_19355 D0Z67_20335 D0Z67_20335 D0Z67_20350 D0Z67_20350 D0Z67_22560 D0Z67_22560 D0Z67_20890 D0Z67_20890 recG recG smc smc recD2 recD2 D0Z67_23695 D0Z67_23695 D0Z67_10860 D0Z67_10860 D0Z67_10870 D0Z67_10870 D0Z67_15955 D0Z67_15955 topA topA D0Z67_29220 D0Z67_29220 D0Z67_29330 D0Z67_29330 D0Z67_29045 D0Z67_29045 D0Z67_21785 D0Z67_21785 D0Z67_22370 D0Z67_22370 D0Z67_22230 D0Z67_22230 D0Z67_22035 D0Z67_22035 D0Z67_22080 D0Z67_22080 D0Z67_22150 D0Z67_22150 D0Z67_23910 D0Z67_23910 D0Z67_21160 D0Z67_21160 D0Z67_21380 D0Z67_21380
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
D0Z67_14865Unannotated protein. (1849 aa)
gyrAUnannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (873 aa)
gyrBUnannotated protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (688 aa)
dnaBUnannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (492 aa)
D0Z67_13990Unannotated protein. (527 aa)
D0Z67_08425Unannotated protein. (458 aa)
D0Z67_05290Unannotated protein. (737 aa)
ruvAUnannotated protein; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
ruvBUnannotated protein; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (356 aa)
D0Z67_04430Unannotated protein. (409 aa)
priAUnannotated protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (715 aa)
D0Z67_03955Unannotated protein. (1556 aa)
D0Z67_13415Unannotated protein. (351 aa)
D0Z67_12835Unannotated protein. (687 aa)
D0Z67_12820Unannotated protein. (551 aa)
D0Z67_11945Unannotated protein. (726 aa)
D0Z67_11665Unannotated protein. (313 aa)
mfdUnannotated protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1181 aa)
D0Z67_17705Unannotated protein. (406 aa)
pcrAUnannotated protein. (826 aa)
D0Z67_19330Unannotated protein; Belongs to the helicase family. UvrD subfamily. (1115 aa)
D0Z67_19335Unannotated protein; Belongs to the helicase family. UvrD subfamily. (1137 aa)
D0Z67_19355Unannotated protein. (722 aa)
D0Z67_20335Unannotated protein. (468 aa)
D0Z67_20350Unannotated protein. (757 aa)
D0Z67_22560Unannotated protein. (693 aa)
D0Z67_20890Unannotated protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (205 aa)
recGUnannotated protein; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (740 aa)
smcUnannotated protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1314 aa)
recD2Unannotated protein; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (766 aa)
D0Z67_23695Unannotated protein. (945 aa)
D0Z67_10860Unannotated protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (93 aa)
D0Z67_10870Unannotated protein. (771 aa)
D0Z67_15955Unannotated protein. (836 aa)
topAUnannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (943 aa)
D0Z67_29220Unannotated protein. (462 aa)
D0Z67_29330Unannotated protein. (203 aa)
D0Z67_29045Unannotated protein. (1753 aa)
D0Z67_21785Unannotated protein. (798 aa)
D0Z67_22370Unannotated protein. (116 aa)
D0Z67_22230Unannotated protein. (817 aa)
D0Z67_22035Unannotated protein. (661 aa)
D0Z67_22080Unannotated protein. (148 aa)
D0Z67_22150Unannotated protein. (707 aa)
D0Z67_23910Unannotated protein. (223 aa)
D0Z67_21160Unannotated protein. (541 aa)
D0Z67_21380Unannotated protein. (806 aa)
Your Current Organism:
Streptomyces seoulensis
NCBI taxonomy Id: 73044
Other names: CIP 105312, IFO 16255, IFO 16668, IMSNU 21266, JCM 10116, NBRC 16255, NBRC 16668, S. seoulensis, Streptomyces sp. USC028, Streptomyces sp. USC046, strain IMSNU-1
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