(11 nodes) Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, and ESCRT I complex network (Musca domestica)

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Your Input:
	A0A1I8M8H1	Uncharacterized protein. (414 aa)
	A0A1I8M9I9	VPS37 C-terminal domain-containing protein. (346 aa)
	A0A1I8MA52	GLUE N-terminal domain-containing protein. (401 aa)
	A0A1I8MAN6	Uncharacterized protein. (217 aa)
	A0A1I8MBC2	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (251 aa)
	A0A1I8MF28	Uncharacterized protein. (174 aa)
	A0A1I8MHY2	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (826 aa)
	A0A1I8MJL9	Uncharacterized protein. (682 aa)
	A0A1I8NGX6	Uncharacterized protein. (355 aa)
	T1P9M7_MUSDO	Modifier of rudimentary protein. (221 aa)
	T1PID4_MUSDO	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (209 aa)

Your Current Organism:

Musca domestica

NCBI taxonomy Id: 7370
Other names: house fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I8M8H1	A0A1I8M9I9	A0A1I8M8H1	A0A1I8M9I9	Uncharacterized protein.	VPS37 C-terminal domain-containing protein.	0.962
A0A1I8M8H1	A0A1I8MA52	A0A1I8M8H1	A0A1I8MA52	Uncharacterized protein.	GLUE N-terminal domain-containing protein.	0.963
A0A1I8M8H1	A0A1I8MAN6	A0A1I8M8H1	A0A1I8MAN6	Uncharacterized protein.	Uncharacterized protein.	0.895
A0A1I8M8H1	A0A1I8MBC2	A0A1I8M8H1	A0A1I8MBC2	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.912
A0A1I8M8H1	A0A1I8MF28	A0A1I8M8H1	A0A1I8MF28	Uncharacterized protein.	Uncharacterized protein.	0.904
A0A1I8M8H1	A0A1I8MHY2	A0A1I8M8H1	A0A1I8MHY2	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.989
A0A1I8M8H1	A0A1I8MJL9	A0A1I8M8H1	A0A1I8MJL9	Uncharacterized protein.	Uncharacterized protein.	0.939
A0A1I8M8H1	A0A1I8NGX6	A0A1I8M8H1	A0A1I8NGX6	Uncharacterized protein.	Uncharacterized protein.	0.982
A0A1I8M8H1	T1P9M7_MUSDO	A0A1I8M8H1	T1P9M7	Uncharacterized protein.	Modifier of rudimentary protein.	0.997
A0A1I8M8H1	T1PID4_MUSDO	A0A1I8M8H1	T1PID4	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.999
A0A1I8M9I9	A0A1I8M8H1	A0A1I8M9I9	A0A1I8M8H1	VPS37 C-terminal domain-containing protein.	Uncharacterized protein.	0.962
A0A1I8M9I9	A0A1I8MA52	A0A1I8M9I9	A0A1I8MA52	VPS37 C-terminal domain-containing protein.	GLUE N-terminal domain-containing protein.	0.834
A0A1I8M9I9	A0A1I8MAN6	A0A1I8M9I9	A0A1I8MAN6	VPS37 C-terminal domain-containing protein.	Uncharacterized protein.	0.699
A0A1I8M9I9	A0A1I8MBC2	A0A1I8M9I9	A0A1I8MBC2	VPS37 C-terminal domain-containing protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.793
A0A1I8M9I9	A0A1I8MF28	A0A1I8M9I9	A0A1I8MF28	VPS37 C-terminal domain-containing protein.	Uncharacterized protein.	0.859
A0A1I8M9I9	A0A1I8MHY2	A0A1I8M9I9	A0A1I8MHY2	VPS37 C-terminal domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.589
A0A1I8M9I9	A0A1I8MJL9	A0A1I8M9I9	A0A1I8MJL9	VPS37 C-terminal domain-containing protein.	Uncharacterized protein.	0.617
A0A1I8M9I9	A0A1I8NGX6	A0A1I8M9I9	A0A1I8NGX6	VPS37 C-terminal domain-containing protein.	Uncharacterized protein.	0.970
A0A1I8M9I9	T1P9M7_MUSDO	A0A1I8M9I9	T1P9M7	VPS37 C-terminal domain-containing protein.	Modifier of rudimentary protein.	0.968
A0A1I8M9I9	T1PID4_MUSDO	A0A1I8M9I9	T1PID4	VPS37 C-terminal domain-containing protein.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.970