(30 nodes) U2 snRNP, and Spliceosomal tri-snRNP complex assembly network (Musca domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1I8M231	Uncharacterized protein. (259 aa)
	A0A1I8M2N1	Uncharacterized protein. (953 aa)
	A0A1I8M2N4	Sm domain-containing protein; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (88 aa)
	A0A1I8M381	Uncharacterized protein. (816 aa)
	A0A1I8M4W9	RRM domain-containing protein. (417 aa)
	A0A1I8M532	RRM domain-containing protein. (121 aa)
	A0A1I8M5J8	CPSF_A domain-containing protein. (1225 aa)
	A0A1I8M6W8	Small nuclear ribonucleoprotein-associated protein. (199 aa)
	A0A1I8M6Y5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (85 aa)
	A0A1I8M8R6	Small nuclear ribonucleoprotein G. (76 aa)
	A0A1I8MDV4	U1 small nuclear ribonucleoprotein C; Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA; Belongs to the U1 small nuclear ribonucleoprotein C family. (153 aa)
	A0A1I8MEL0	Small nuclear ribonucleoprotein Sm D3. (147 aa)
	A0A1I8MGN7	TOG domain-containing protein. (1317 aa)
	A0A1I8MIY3	Nop domain-containing protein. (500 aa)
	A0A1I8MJ60	Uncharacterized protein. (907 aa)
	A0A1I8MK54	WD_REPEATS_REGION domain-containing protein. (256 aa)
	A0A1I8MMX1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (124 aa)
	A0A1I8MQB4	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (94 aa)
	A0A1I8MTD7	Uncharacterized protein. (2142 aa)
	A0A1I8MX17	Uncharacterized protein. (331 aa)
	A0A1I8N0K5	Tr-type G domain-containing protein. (975 aa)
	A0A1I8N319	Uncharacterized protein. (156 aa)
	A0A1I8NBC0	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
	A0A1I8NCD0	Uncharacterized protein; Belongs to the DEAD box helicase family. (769 aa)
	A0A1I8NEX1	Sm domain-containing protein. (140 aa)
	T1P8H2_MUSDO	Small nuclear ribonucleoprotein Sm D2. (119 aa)
	T1P8J3_MUSDO	PRP1 splicing factor. (931 aa)
	T1PIW3_MUSDO	PROCN domain protein. (2388 aa)
	T1PJC0_MUSDO	RNA recognition protein. (216 aa)
	T1PMH9_MUSDO	PSP domain-containing protein. (808 aa)

Your Current Organism:

Musca domestica

NCBI taxonomy Id: 7370
Other names: house fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I8M231	A0A1I8M2N1	A0A1I8M231	A0A1I8M2N1	Uncharacterized protein.	Uncharacterized protein.	0.944
A0A1I8M231	A0A1I8M2N4	A0A1I8M231	A0A1I8M2N4	Uncharacterized protein.	Sm domain-containing protein; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.995
A0A1I8M231	A0A1I8M381	A0A1I8M231	A0A1I8M381	Uncharacterized protein.	Uncharacterized protein.	0.748
A0A1I8M231	A0A1I8M4W9	A0A1I8M231	A0A1I8M4W9	Uncharacterized protein.	RRM domain-containing protein.	0.991
A0A1I8M231	A0A1I8M532	A0A1I8M231	A0A1I8M532	Uncharacterized protein.	RRM domain-containing protein.	0.917
A0A1I8M231	A0A1I8M5J8	A0A1I8M231	A0A1I8M5J8	Uncharacterized protein.	CPSF_A domain-containing protein.	0.996
A0A1I8M231	A0A1I8M6W8	A0A1I8M231	A0A1I8M6W8	Uncharacterized protein.	Small nuclear ribonucleoprotein-associated protein.	0.995
A0A1I8M231	A0A1I8M6Y5	A0A1I8M231	A0A1I8M6Y5	Uncharacterized protein.	Splicing factor 3B subunit 5; Belongs to the SF3B5 family.	0.989
A0A1I8M231	A0A1I8M8R6	A0A1I8M231	A0A1I8M8R6	Uncharacterized protein.	Small nuclear ribonucleoprotein G.	0.995
A0A1I8M231	A0A1I8MDV4	A0A1I8M231	A0A1I8MDV4	Uncharacterized protein.	U1 small nuclear ribonucleoprotein C; Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA; Belongs to the U1 small nuclear ribonucleoprotein C family.	0.992
A0A1I8M231	A0A1I8MEL0	A0A1I8M231	A0A1I8MEL0	Uncharacterized protein.	Small nuclear ribonucleoprotein Sm D3.	0.996
A0A1I8M231	A0A1I8MGN7	A0A1I8M231	A0A1I8MGN7	Uncharacterized protein.	TOG domain-containing protein.	0.996
A0A1I8M231	A0A1I8MIY3	A0A1I8M231	A0A1I8MIY3	Uncharacterized protein.	Nop domain-containing protein.	0.935
A0A1I8M231	A0A1I8MJ60	A0A1I8M231	A0A1I8MJ60	Uncharacterized protein.	Uncharacterized protein.	0.989
A0A1I8M231	A0A1I8MK54	A0A1I8M231	A0A1I8MK54	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.896
A0A1I8M231	A0A1I8MMX1	A0A1I8M231	A0A1I8MMX1	Uncharacterized protein.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.995
A0A1I8M231	A0A1I8MQB4	A0A1I8M231	A0A1I8MQB4	Uncharacterized protein.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.944
A0A1I8M231	A0A1I8MTD7	A0A1I8M231	A0A1I8MTD7	Uncharacterized protein.	Uncharacterized protein.	0.989
A0A1I8M231	A0A1I8MX17	A0A1I8M231	A0A1I8MX17	Uncharacterized protein.	Uncharacterized protein.	0.994
A0A1I8M231	A0A1I8N0K5	A0A1I8M231	A0A1I8N0K5	Uncharacterized protein.	Tr-type G domain-containing protein.	0.991