40 items (Musca domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T1P884_MUSDO	Non-specific serine/threonine protein kinase. (522 aa)
	A0A1I8M0T8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1247 aa)
	A0A1I8M2D0	BZIP domain-containing protein. (449 aa)
	A0A1I8M2V3	RING-type domain-containing protein. (456 aa)
	A0A1I8M3V4	J domain-containing protein. (2431 aa)
	A0A1I8M3W7	Receptor protein-tyrosine kinase. (1438 aa)
	A0A1I8M6E8	ORC_WH_C domain-containing protein. (724 aa)
	A0A1I8MEW6	Protein kinase domain-containing protein. (1290 aa)
	A0A1I8MF96	Uncharacterized protein. (445 aa)
	A0A1I8MHJ7	KA1 domain-containing protein. (182 aa)
	A0A1I8MHY2	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (826 aa)
	A0A1I8MME5	Receptor protein-tyrosine kinase. (1592 aa)
	A0A1I8MNR0	Beta-TrCP_D domain-containing protein. (99 aa)
	A0A1I8MQR6	EGF-like domain-containing protein. (281 aa)
	A0A1I8MRB5	COesterase domain-containing protein. (1008 aa)
	A0A1I8MRZ3	ORC_WH_C domain-containing protein. (724 aa)
	A0A1I8MX15	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1400 aa)
	A0A1I8MZ76	BTB domain-containing protein. (727 aa)
	T1PA53_MUSDO	RNA recognition protein. (422 aa)
	A0A1I8N025	Uncharacterized protein. (785 aa)
	T1P976_MUSDO	Mitogen-activated protein kinase. (380 aa)
	A0A1I8N2R0	Uncharacterized protein. (740 aa)
	A0A1I8N3A7	VIR_N domain-containing protein. (1902 aa)
	A0A1I8N3C6	Uncharacterized protein. (1984 aa)
	A0A1I8N449	Non-specific serine/threonine protein kinase. (1013 aa)
	A0A1I8N4M1	Uncharacterized protein. (900 aa)
	A0A1I8N5K7	Uncharacterized protein. (1944 aa)
	A0A1I8N603	Uncharacterized protein. (134 aa)
	A0A1I8N6L2	Uncharacterized protein. (2230 aa)
	A0A1I8N8F0	Uncharacterized protein. (6040 aa)
	A0A1I8N968	WD_REPEATS_REGION domain-containing protein. (416 aa)
	A0A1I8NAS8	UBA domain-containing protein. (411 aa)
	A0A1I8ND78	WD_REPEATS_REGION domain-containing protein. (524 aa)
	A0A1I8NDP7	Mitogen-activated protein kinase. (371 aa)
	T1PJX3_MUSDO	Dual specificity phosphatase. (399 aa)
	A0A1I8NE79	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1076 aa)
	A0A1I8NEI6	Uncharacterized protein. (1222 aa)
	A0A1I8NFS4	Uncharacterized protein. (360 aa)
	A0A1I8NGF6	Uncharacterized protein; Belongs to the DOCK family. (1995 aa)
	A0A1I8NL85	Uncharacterized protein. (119 aa)

Your Current Organism:

Musca domestica

NCBI taxonomy Id: 7370
Other names: house fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I8M0T8	A0A1I8M3W7	A0A1I8M0T8	A0A1I8M3W7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Receptor protein-tyrosine kinase.	0.903
A0A1I8M0T8	A0A1I8MF96	A0A1I8M0T8	A0A1I8MF96	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.497
A0A1I8M0T8	A0A1I8MME5	A0A1I8M0T8	A0A1I8MME5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Receptor protein-tyrosine kinase.	0.828
A0A1I8M0T8	A0A1I8MX15	A0A1I8M0T8	A0A1I8MX15	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.623
A0A1I8M0T8	A0A1I8NAS8	A0A1I8M0T8	A0A1I8NAS8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	UBA domain-containing protein.	0.497
A0A1I8M0T8	A0A1I8NE79	A0A1I8M0T8	A0A1I8NE79	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.951
A0A1I8M0T8	T1P884_MUSDO	A0A1I8M0T8	T1P884	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Non-specific serine/threonine protein kinase.	0.608
A0A1I8M3W7	A0A1I8M0T8	A0A1I8M3W7	A0A1I8M0T8	Receptor protein-tyrosine kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.903
A0A1I8M3W7	A0A1I8MF96	A0A1I8M3W7	A0A1I8MF96	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.992
A0A1I8M3W7	A0A1I8MHY2	A0A1I8M3W7	A0A1I8MHY2	Receptor protein-tyrosine kinase.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.796
A0A1I8M3W7	A0A1I8MME5	A0A1I8M3W7	A0A1I8MME5	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.642
A0A1I8M3W7	A0A1I8MQR6	A0A1I8M3W7	A0A1I8MQR6	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.985
A0A1I8M3W7	A0A1I8N2R0	A0A1I8M3W7	A0A1I8N2R0	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.996
A0A1I8M3W7	A0A1I8NAS8	A0A1I8M3W7	A0A1I8NAS8	Receptor protein-tyrosine kinase.	UBA domain-containing protein.	0.927
A0A1I8M3W7	A0A1I8NE79	A0A1I8M3W7	A0A1I8NE79	Receptor protein-tyrosine kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.814
A0A1I8M3W7	T1P884_MUSDO	A0A1I8M3W7	T1P884	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase.	0.456
A0A1I8MEW6	A0A1I8NDP7	A0A1I8MEW6	A0A1I8NDP7	Protein kinase domain-containing protein.	Mitogen-activated protein kinase.	0.988
A0A1I8MEW6	T1P976_MUSDO	A0A1I8MEW6	T1P976	Protein kinase domain-containing protein.	Mitogen-activated protein kinase.	0.988
A0A1I8MEW6	T1PJX3_MUSDO	A0A1I8MEW6	T1PJX3	Protein kinase domain-containing protein.	Dual specificity phosphatase.	0.733
A0A1I8MF96	A0A1I8M0T8	A0A1I8MF96	A0A1I8M0T8	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.497