(48 nodes) Chromosome Maintenance network (Musca domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1I8NL57	Uncharacterized protein. (237 aa)
	A0A1I8MX39	Uncharacterized protein. (135 aa)
	A0A1I8MWB4	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (233 aa)
	T1PGT4_MUSDO	Ribosomal protein L7Ae/L30e/S12e/Gadd47. (160 aa)
	T1PG32_MUSDO	SNF2 family. (1019 aa)
	T1P9S7_MUSDO	Serine/threonine-protein phosphatase. (303 aa)
	T1P7S3_MUSDO	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A1I8NL95	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
	A0A1I8MY21	TM2 domain-containing protein. (238 aa)
	A0A1I8NKZ5	Uncharacterized protein. (192 aa)
	A0A1I8NIA9	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (478 aa)
	A0A1I8NHT7	Uncharacterized protein. (64 aa)
	A0A1I8NHI0	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
	A0A1I8NG87	SHQ1 domain-containing protein. (473 aa)
	A0A1I8NG43	Uncharacterized protein. (1604 aa)
	A0A1I8NDH7	Uncharacterized protein. (2559 aa)
	A0A1I8M3D2	Uncharacterized protein. (965 aa)
	A0A1I8M4U6	Uncharacterized protein. (2208 aa)
	A0A1I8MVR6	Uncharacterized protein. (2932 aa)
	A0A1I8MV60	Uncharacterized protein. (192 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (663 aa)
	A0A1I8MJM0	Uncharacterized protein. (426 aa)
	A0A1I8MNT3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	A0A1I8MP59	WD_REPEATS_REGION domain-containing protein. (621 aa)
	A0A1I8MP82	AAA domain-containing protein. (332 aa)
	A0A1I8M557	AAA domain-containing protein. (333 aa)
	A0A1I8M652	AAA domain-containing protein. (360 aa)
	A0A1I8M6E0	3'-5' exonuclease domain-containing protein. (596 aa)
	A0A1I8M993	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (602 aa)
	A0A1I8MAJ5	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
	A0A1I8MBT6	PUA domain-containing protein. (515 aa)
	A0A1I8MQY4	Uncharacterized protein. (148 aa)
	A0A1I8MEM5	Uncharacterized protein. (490 aa)
	A0A1I8MIW8	Uncharacterized protein. (433 aa)
	A0A1I8MJD9	Uncharacterized protein. (1796 aa)
	A0A1I8ND53	Uncharacterized protein. (187 aa)
	A0A1I8NAR6	Uncharacterized protein. (189 aa)
	A0A1I8N9D2	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A1I8N8A4	Uncharacterized protein. (217 aa)
	A0A1I8N7R7	Uncharacterized protein. (860 aa)
	A0A1I8N760	Uncharacterized protein. (630 aa)
	A0A1I8N525	AAA domain-containing protein. (983 aa)
	A0A1I8N427	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (428 aa)
	A0A1I8N2Y3	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	A0A1I8N232	3'-5' exonuclease domain-containing protein. (298 aa)
	A0A1I8N220	Uncharacterized protein. (1266 aa)
	A0A1I8N0I4	AAA domain-containing protein. (356 aa)
	A0A1I8MZ83	Uncharacterized protein. (1447 aa)

Your Current Organism:

Musca domestica

NCBI taxonomy Id: 7370
Other names: house fly

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I8M3D2	A0A1I8MVR6	A0A1I8M3D2	A0A1I8MVR6	Uncharacterized protein.	Uncharacterized protein.	0.893
A0A1I8M3D2	A0A1I8MZ83	A0A1I8M3D2	A0A1I8MZ83	Uncharacterized protein.	Uncharacterized protein.	0.893
A0A1I8M3D2	A0A1I8N220	A0A1I8M3D2	A0A1I8N220	Uncharacterized protein.	Uncharacterized protein.	0.893
A0A1I8M557	A0A1I8M652	A0A1I8M557	A0A1I8M652	AAA domain-containing protein.	AAA domain-containing protein.	0.999
A0A1I8M557	A0A1I8MEM5	A0A1I8M557	A0A1I8MEM5	AAA domain-containing protein.	Uncharacterized protein.	0.611
A0A1I8M557	A0A1I8MIW8	A0A1I8M557	A0A1I8MIW8	AAA domain-containing protein.	Uncharacterized protein.	0.572
A0A1I8M557	A0A1I8MJM0	A0A1I8M557	A0A1I8MJM0	AAA domain-containing protein.	Uncharacterized protein.	0.947
A0A1I8M557	A0A1I8MNT3	A0A1I8M557	A0A1I8MNT3	AAA domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.662
A0A1I8M557	A0A1I8MP82	A0A1I8M557	A0A1I8MP82	AAA domain-containing protein.	AAA domain-containing protein.	0.999
A0A1I8M557	A0A1I8MQY4	A0A1I8M557	A0A1I8MQY4	AAA domain-containing protein.	Uncharacterized protein.	0.954
A0A1I8M557	A0A1I8N0I4	A0A1I8M557	A0A1I8N0I4	AAA domain-containing protein.	AAA domain-containing protein.	0.999
A0A1I8M557	A0A1I8N525	A0A1I8M557	A0A1I8N525	AAA domain-containing protein.	AAA domain-containing protein.	0.985
A0A1I8M557	A0A1I8N7R7	A0A1I8M557	A0A1I8N7R7	AAA domain-containing protein.	Uncharacterized protein.	0.662
A0A1I8M557	A0A1I8NG43	A0A1I8M557	A0A1I8NG43	AAA domain-containing protein.	Uncharacterized protein.	0.633
A0A1I8M652	A0A1I8M557	A0A1I8M652	A0A1I8M557	AAA domain-containing protein.	AAA domain-containing protein.	0.999
A0A1I8M652	A0A1I8MEM5	A0A1I8M652	A0A1I8MEM5	AAA domain-containing protein.	Uncharacterized protein.	0.658
A0A1I8M652	A0A1I8MIW8	A0A1I8M652	A0A1I8MIW8	AAA domain-containing protein.	Uncharacterized protein.	0.578
A0A1I8M652	A0A1I8MJM0	A0A1I8M652	A0A1I8MJM0	AAA domain-containing protein.	Uncharacterized protein.	0.959
A0A1I8M652	A0A1I8MNT3	A0A1I8M652	A0A1I8MNT3	AAA domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.728
A0A1I8M652	A0A1I8MP82	A0A1I8M652	A0A1I8MP82	AAA domain-containing protein.	AAA domain-containing protein.	0.999