STRINGSTRING
E6KV61_9PAST E6KV61_9PAST purD purD fadD fadD rpmF rpmF plsB plsB rpsF rpsF priB priB rplU rplU metE metE acrR acrR priA priA rpmE rpmE rpmG rpmG rpmB rpmB radC radC slmA slmA E6KVH4_9PAST E6KVH4_9PAST kdkA kdkA rplQ rplQ rpsD rpsD rpsK rpsK GCA_001059425_00307 GCA_001059425_00307 rpmJ rpmJ rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ E6KX09_9PAST E6KX09_9PAST dinG dinG rpsL rpsL rpsG rpsG dnaQ dnaQ rnhA rnhA E6KYR8_9PAST E6KYR8_9PAST GCA_001059425_00457 GCA_001059425_00457 bioB bioB nagE nagE hemH hemH lemA lemA E6KYH4_9PAST E6KYH4_9PAST guaB guaB rplY rplY ihfA ihfA sspB sspB truA truA rpsI rpsI rplM rplM matP matP GCA_001059425_00658 GCA_001059425_00658 dnaB dnaB sulA sulA rnfC rnfC nth nth tadA tadA fis fis GCA_001059425_00822 GCA_001059425_00822 menF menF ptpA ptpA recO recO rpsB rpsB metY metY ppx ppx argB argB rpsP rpsP E6KZS8_9PAST E6KZS8_9PAST E6L095_9PAST E6L095_9PAST nrdD2 nrdD2 rplK rplK rplA rplA rplJ rplJ rplL rplL nudC nudC hup2 hup2 dtd dtd YqgF YqgF E6KXG7_9PAST E6KXG7_9PAST ppa2 ppa2 rpmI rpmI ccdA ccdA folK folK ligA ligA infB infB nusA nusA cobB cobB recN recN yciA yciA topB topB recR recR YbaB YbaB E6KWG1_9PAST E6KWG1_9PAST ogt ogt rpmE2 rpmE2 rpmJ-2 rpmJ-2 rpmA rpmA dapF2 dapF2 E6KZ07_9PAST E6KZ07_9PAST tolA tolA tfoX tfoX ygfY ygfY lysA lysA recQ recQ topA2 topA2 engD engD tig2 tig2 ribF ribF pilF pilF E6KZL7_9PAST E6KZL7_9PAST hda hda dnaG dnaG rpsU rpsU recF recF yfiA yfiA rpmH rpmH RaiA RaiA ybeY ybeY tmcA tmcA E6L0M4_9PAST E6L0M4_9PAST ispE ispE rarA rarA rpsA rpsA ihfB ihfB E6KWX3_9PAST E6KWX3_9PAST ptsG ptsG hemA hemA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E6KV61_9PASTUnannotated protein. (130 aa)
purDUnannotated protein; Belongs to the GARS family. (429 aa)
fadDUnannotated protein. (595 aa)
rpmFUnannotated protein; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
plsBUnannotated protein; Belongs to the GPAT/DAPAT family. (813 aa)
rpsFUnannotated protein; Binds together with S18 to 16S ribosomal RNA. (125 aa)
priBUnannotated protein; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (108 aa)
rplUUnannotated protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (76 aa)
metEUnannotated protein; Binds to the 23S rRNA. (149 aa)
acrRUnannotated protein. (191 aa)
priAUnannotated protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa)
rpmEUnannotated protein; Binds the 23S rRNA. (70 aa)
rpmGUnannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (56 aa)
rpmBUnannotated protein; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
radCUnannotated protein; Belongs to the UPF0758 family. (219 aa)
slmAUnannotated protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (199 aa)
E6KVH4_9PASTUnannotated protein. (436 aa)
kdkAUnannotated protein; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. (241 aa)
rplQUnannotated protein. (129 aa)
rpsDUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rpsKUnannotated protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
GCA_001059425_00307Unannotated protein. (118 aa)
rpmJUnannotated protein; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rplOUnannotated protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmDUnannotated protein. (59 aa)
rpsEUnannotated protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (166 aa)
rplRUnannotated protein; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rplFUnannotated protein; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsHUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpsNUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rplEUnannotated protein; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rplXUnannotated protein; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (103 aa)
rplNUnannotated protein; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rpsQUnannotated protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (85 aa)
rpmCUnannotated protein; Belongs to the universal ribosomal protein uL29 family. (63 aa)
rplPUnannotated protein; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rpsCUnannotated protein; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (235 aa)
rplVUnannotated protein; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (110 aa)
rpsSUnannotated protein; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa)
rplBUnannotated protein; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rplWUnannotated protein; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa)
rplDUnannotated protein; Forms part of the polypeptide exit tunnel. (200 aa)
rplCUnannotated protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (208 aa)
rpsJUnannotated protein; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
E6KX09_9PASTUnannotated protein. (245 aa)
dinGUnannotated protein. (648 aa)
rpsLUnannotated protein; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa)
rpsGUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
dnaQUnannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (253 aa)
rnhAUnannotated protein; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (155 aa)
E6KYR8_9PASTUnannotated protein. (201 aa)
GCA_001059425_00457Unannotated protein. (330 aa)
bioBUnannotated protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (334 aa)
nagEUnannotated protein. (488 aa)
hemHUnannotated protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (353 aa)
lemAUnannotated protein. (193 aa)
E6KYH4_9PASTUnannotated protein. (255 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
rplYUnannotated protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (95 aa)
ihfAUnannotated protein; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (98 aa)
sspBUnannotated protein. (146 aa)
truAUnannotated protein; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (261 aa)
rpsIUnannotated protein; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplMUnannotated protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
matPUnannotated protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (148 aa)
GCA_001059425_00658Unannotated protein. (144 aa)
dnaBUnannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa)
sulAUnannotated protein. (297 aa)
rnfCUnannotated protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (749 aa)
nthUnannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
tadAUnannotated protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (175 aa)
fisUnannotated protein; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (98 aa)
GCA_001059425_00822Unannotated protein. (89 aa)
menFUnannotated protein; Catalyzes the conversion of chorismate to isochorismate. (435 aa)
ptpAUnannotated protein; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (157 aa)
recOUnannotated protein; Involved in DNA repair and RecF pathway recombination. (216 aa)
rpsBUnannotated protein; Belongs to the universal ribosomal protein uS2 family. (240 aa)
metYUnannotated protein. (422 aa)
ppxUnannotated protein. (351 aa)
argBUnannotated protein; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa)
rpsPUnannotated protein; Belongs to the bacterial ribosomal protein bS16 family. (82 aa)
E6KZS8_9PASTUnannotated protein. (532 aa)
E6L095_9PASTUnannotated protein. (454 aa)
nrdD2Unannotated protein; Participates in transcription elongation, termination and antitermination. (183 aa)
rplKUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
rplAUnannotated protein; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplJUnannotated protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (163 aa)
rplLUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa)
nudCUnannotated protein; Belongs to the Nudix hydrolase family. NudC subfamily. (261 aa)
hup2Unannotated protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
dtdUnannotated protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (144 aa)
YqgFUnannotated protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (139 aa)
E6KXG7_9PASTUnannotated protein. (293 aa)
ppa2Unannotated protein; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
rpmIUnannotated protein; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
ccdAUnannotated protein. (213 aa)
folKUnannotated protein. (168 aa)
ligAUnannotated protein. (276 aa)
infBUnannotated protein; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (829 aa)
nusAUnannotated protein; Participates in both transcription termination and antitermination. (498 aa)
cobBUnannotated protein; Belongs to the sirtuin family. Class III subfamily. (236 aa)
recNUnannotated protein; May be involved in recombinational repair of damaged DNA. (558 aa)
yciAUnannotated protein. (153 aa)
topBUnannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (640 aa)
recRUnannotated protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (200 aa)
YbaBUnannotated protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (109 aa)
E6KWG1_9PASTUnannotated protein. (357 aa)
ogtUnannotated protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (179 aa)
rpmE2Unannotated protein. (88 aa)
rpmJ-2Unannotated protein; Belongs to the bacterial ribosomal protein bL36 family. (46 aa)
rpmAUnannotated protein; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
dapF2Unannotated protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
E6KZ07_9PASTUnannotated protein. (190 aa)
tolAUnannotated protein. (371 aa)
tfoXUnannotated protein. (211 aa)
ygfYUnannotated protein. (84 aa)
lysAUnannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa)
recQUnannotated protein. (629 aa)
topA2Unannotated protein. (182 aa)
engDUnannotated protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (363 aa)
tig2Unannotated protein; Binds directly to 16S ribosomal RNA. (87 aa)
ribFUnannotated protein; Belongs to the ribF family. (312 aa)
pilFUnannotated protein. (183 aa)
E6KZL7_9PASTUnannotated protein. (150 aa)
hdaUnannotated protein; Belongs to the DnaA family. (234 aa)
dnaGUnannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (586 aa)
rpsUUnannotated protein; Belongs to the bacterial ribosomal protein bS21 family. (71 aa)
recFUnannotated protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (358 aa)
yfiAUnannotated protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (453 aa)
rpmHUnannotated protein; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
RaiAUnannotated protein. (107 aa)
ybeYUnannotated protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (154 aa)
tmcAUnannotated protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (645 aa)
E6L0M4_9PASTUnannotated protein. (181 aa)
ispEUnannotated protein; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (306 aa)
rarAUnannotated protein. (446 aa)
rpsAUnannotated protein; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (548 aa)
ihfBUnannotated protein; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (94 aa)
E6KWX3_9PASTUnannotated protein. (112 aa)
ptsGUnannotated protein. (497 aa)
hemAUnannotated protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (434 aa)
Your Current Organism:
Aggregatibacter segnis
NCBI taxonomy Id: 739
Other names: A. segnis, ATCC 33393, CCUG 10787, CCUG 12838, CIP 103292, DSM 21418, Haemophilus segnis, NCTC 10977, strain HK 316, strain HK316
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