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cysK cysK metF metF hisB hisB hisH hisH hisG hisG hisZ hisZ lysC lysC tyrA tyrA aroF1 aroF1 asd asd hisD hisD aroE aroE ADW21679.1 ADW21679.1 lysA lysA metB1 metB1 metB2 metB2 metX metX ADW22020.1 ADW22020.1 metH metH hisA hisA trpC trpC trpA trpA trpB trpB pheA pheA hisF hisF hisI hisI ADW22567.1 ADW22567.1 thrC thrC aroA aroA aroC2 aroC2 aroK aroK ADW22677.1 ADW22677.1 thrB thrB trpF trpF trpD trpD pabA pabA trpE trpE aroF2 aroF2 ADW22911.1 ADW22911.1 metK metK ADW23049.1 ADW23049.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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cysKCysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
hisBImidazoleglycerol-phosphate dehydratase. (194 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit. (201 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (207 aa)
hisZATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (361 aa)
lysCAspartate kinase; Monofunctional class; Belongs to the aspartokinase family. (405 aa)
tyrAPrephenate dehydrogenase. (359 aa)
aroF1Phospho-2-dehydro-3-deoxyheptonate aldolase. (344 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (331 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (412 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (264 aa)
ADW21679.1Cobalamin biosynthesis aminotransferase. (331 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (387 aa)
metB1Homocysteine synthase; OAH sulfhydrylase; O-acetylhomoserinesulfhydrylase. (412 aa)
metB2Homocysteine synthase; OAH sulfhydrylase; O-acetylhomoserinesulfhydrylase. (421 aa)
metXHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (380 aa)
ADW22020.1Alternative anthranilate synthase component I+II. (616 aa)
metHMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1182 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase. (236 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (245 aa)
trpATryptophan synthase, subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa)
trpBTryptophan synthase, subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
pheAPrephenate dehydratase. (308 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa)
hisIHistidine biosynthesis bifunctional protein hisIE; In the N-terminal section; belongs to the PRA-CH family. (211 aa)
ADW22567.1Homoserine dehydrogenase. (332 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (351 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (441 aa)
aroC2Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)
ADW22677.13-dehydroquinate synthase. (344 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa)
trpFN-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (204 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (329 aa)
pabAPara-aminobenzoate synthase glutamine amidotransferase component II; ADC synthase. (193 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (462 aa)
aroF2Phospho-2-dehydro-3-deoxyheptonate aldolase. (354 aa)
ADW22911.1Aminotransferase, class I. (355 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa)
ADW23049.1Aspartate aminotransferase; Aspat; transaminase a. (385 aa)
Your Current Organism:
Thermus scotoductus
NCBI taxonomy Id: 743525
Other names: T. scotoductus SA-01, Thermus scotoductus SA-01, Thermus scotoductus str. SA-01, Thermus scotoductus strain SA-01, Thermus sp. SA-01
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