STRINGSTRING
ADW22128.1 ADW22128.1 hemD2 hemD2 hemB hemB nnrD nnrD ADW22677.1 ADW22677.1 aroC2 aroC2 nth nth thrC thrC pheA pheA trpB trpB trpA trpA ADW22127.1 ADW22127.1 menC menC hemD1 hemD1 cobA cobA ADW21781.1 ADW21781.1 ADW21779.1 ADW21779.1 ADW21704.1 ADW21704.1 dapA2 dapA2 dapA1 dapA1 acnA acnA fumC fumC ADW21453.1 ADW21453.1 leuC leuC leuD leuD ilvD ilvD mqnA mqnA hisB hisB crt crt aroQ aroQ phhB phhB mutM mutM fabZ fabZ paaG1 paaG1 ADW20886.1 ADW20886.1 mgsA mgsA hacB hacB hacA hacA eno eno
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ADW22128.1Indigoidine synthase A like protein. (189 aa)
hemD2uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (212 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (326 aa)
nnrDCarbohydrate kinase family; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bo [...] (485 aa)
ADW22677.13-dehydroquinate synthase. (344 aa)
aroC2Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (217 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (351 aa)
pheAPrephenate dehydratase. (308 aa)
trpBTryptophan synthase, subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
trpATryptophan synthase, subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa)
ADW22127.1Indigoidine synthase A like protein. (92 aa)
menCO-succinylbenzoic acid (OSB) synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (369 aa)
hemD1uroporphyrinogen-III synthase. (254 aa)
cobAuroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (250 aa)
ADW21781.12-hydroxypentadienoic acidhydratase. (258 aa)
ADW21779.14-oxalocrotonate decarboxylase. (231 aa)
ADW21704.1N-acetylmuramic acid 6-phosphate etherase; MurNAc-6-petherase. (286 aa)
dapA2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
dapA1Dihydrodipicolinate synthase; Belongs to the DapA family. (284 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
ADW21453.1enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (253 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (556 aa)
mqnAConserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (270 aa)
hisBImidazoleglycerol-phosphate dehydratase. (194 aa)
crt3-hydroxybutyryl-CoA dehydratase; Crotonase; Belongs to the enoyl-CoA hydratase/isomerase family. (273 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa)
phhBPCD; pterin carbinolaminedehydratase; 4-alpha-hydroxy-tetrahydropterin dehydratase; PHS. (79 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (265 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa)
paaG1enoyl-CoA hydratase PaaG. (254 aa)
ADW20886.1Conserved hypothetical protein. (126 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (133 aa)
hacBHomoaconitase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa)
hacAHomoaconitase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (421 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (422 aa)
Your Current Organism:
Thermus scotoductus
NCBI taxonomy Id: 743525
Other names: T. scotoductus SA-01, Thermus scotoductus SA-01, Thermus scotoductus str. SA-01, Thermus scotoductus strain SA-01, Thermus sp. SA-01
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