STRINGSTRING
aroE aroE ADW21179.1 ADW21179.1 ADW22868.1 ADW22868.1 ADW22869.1 ADW22869.1 aroF2 aroF2 ADW22971.1 ADW22971.1 ADW22991.1 ADW22991.1 gdhA1 gdhA1 ADW22677.1 ADW22677.1 aroK aroK aroC2 aroC2 ADW22655.1 ADW22655.1 aroA aroA ADW22561.1 ADW22561.1 ppc ppc aroH aroH nadA nadA lysA lysA ADW21694.1 ADW21694.1 dapA2 dapA2 ADW21597.1 ADW21597.1 dapA1 dapA1 fumC fumC asd asd mdh mdh lysC lysC sfcA sfcA ADW21191.1 ADW21191.1 folB folB folP folP folK folK ADW21082.1 ADW21082.1 aroQ aroQ ADW21128.1 ADW21128.1 ADW21132.1 ADW21132.1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (264 aa)
ADW21179.1N-acyl-L-amino acid amidohydrolase. (437 aa)
ADW22868.1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (516 aa)
ADW22869.1Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase. (307 aa)
aroF2Phospho-2-dehydro-3-deoxyheptonate aldolase. (354 aa)
ADW22971.1Carboxypeptidase G2. (371 aa)
ADW22991.1Deacetylase. (356 aa)
gdhA1Glutamate dehydrogenase; GDH; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa)
ADW22677.13-dehydroquinate synthase. (344 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)
aroC2Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa)
ADW22655.1Glutamate synthase, NADPH, large subunit. (1492 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (441 aa)
ADW22561.1Zinc finger, cdgsh-type. (69 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (861 aa)
aroHChorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (122 aa)
nadAQuinolinate synthetase complex, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (307 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (387 aa)
ADW21694.1Acetylornithine deacetylase. (385 aa)
dapA2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
ADW21597.1ArgE/DapE/Acy1 family peptidase. (437 aa)
dapA1Dihydrodipicolinate synthase; Belongs to the DapA family. (284 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (331 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa)
lysCAspartate kinase; Monofunctional class; Belongs to the aspartokinase family. (405 aa)
sfcANAD-dependent malic enzyme; NAD-ME. (576 aa)
ADW21191.1Conserved hypothetical protein. (241 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (272 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (159 aa)
ADW21082.1Conserved domain protein. (64 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa)
ADW21128.1Peptidase, M20/M25/M40 family. (327 aa)
ADW21132.1Folylpolyglutamate synthase/dihydrofolate synthase. (390 aa)
Your Current Organism:
Thermus scotoductus
NCBI taxonomy Id: 743525
Other names: T. scotoductus SA-01, Thermus scotoductus SA-01, Thermus scotoductus str. SA-01, Thermus scotoductus strain SA-01, Thermus sp. SA-01
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