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| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (407 aa) |
| | cysK | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa) |
| | argB1 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (248 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa) |
| | lysS1 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (376 aa) |
| | hacA | Homoaconitase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (421 aa) |
| | hacB | Homoaconitase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | lysX | Lysine biosynthesis enzyme LysX; Belongs to the RimK family. (298 aa) |
| | argC1 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (346 aa) |
| | argB2 | Acetylglutamate kinase; Catalyzes the phosphorylation of LysW-gamma-alpha- aminoadipate; Belongs to the acetylglutamate kinase family. LysZ subfamily. (269 aa) |
| | ADW20838.1 | Carbon-nitrogen hydrolase family protein. (288 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa) |
| | argH1 | Argininosuccinate lyase. (462 aa) |
| | ADW20916.1 | Acetyltransferase; Belongs to the acetyltransferase family. (179 aa) |
| | carA | Carbamoyl-phosphate synthase, small, subunit; Belongs to the CarA family. (391 aa) |
| | ADW20922.1 | L-threo-3-hydroxyaspartate dehydratase. (312 aa) |
| | ADW20971.1 | Serine-pyruvate aminotransferase. (353 aa) |
| | lysK | Acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine. (362 aa) |
| | rocD | Ornithine aminotransferase; Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (397 aa) |
| | csd | SCL; selenocysteine beta-lyase; selenocysteine reductase; selenocysteine lyase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (404 aa) |
| | ADW21082.1 | Conserved domain protein. (64 aa) |
| | ADW21128.1 | Peptidase, M20/M25/M40 family. (327 aa) |
| | glnA | Glutamine synthetase, type I. (446 aa) |
| | ADW21179.1 | N-acyl-L-amino acid amidohydrolase. (437 aa) |
| | ADW21213.1 | Transcriptional regulator. (396 aa) |
| | rocF | Arginase; Belongs to the arginase family. (327 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit. (201 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (317 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (349 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvPA | Glycine decarboxylase, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (438 aa) |
| | gcvPB | Glycine decarboxylase, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (474 aa) |
| | lysC | Aspartate kinase; Monofunctional class; Belongs to the aspartokinase family. (405 aa) |
| | tyrA | Prephenate dehydrogenase. (359 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (556 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (345 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | ADW21411.1 | L-threonine 3-dehydrogenase. (343 aa) |
| | mtnA | S-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (330 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (331 aa) |
| | mqnB | Futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (225 aa) |
| | ilvB | Acetolactate synthase, large subunit. (562 aa) |
| | ilvN | Acetolactate synthase, small subunit. (170 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (518 aa) |
| | ADW21469.1 | 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (550 aa) |
| | dapA1 | Dihydrodipicolinate synthase; Belongs to the DapA family. (284 aa) |
| | ADW21547.1 | Conserved hypothetical protein. (691 aa) |
| | patA | PAT; PATase; putrescine--2-oxoglutaricacid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (416 aa) |
| | argH2 | Argininosuccinate lyase; Asal 2; arginosuccinase 2. (482 aa) |
| | ADW21597.1 | ArgE/DapE/Acy1 family peptidase. (437 aa) |
| | speB | Agmatinase; Belongs to the arginase family. (290 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | gabT1 | L-aibat; gaba-at; gaba aminotransferase; glutamate:succinic semialdehydetransaminase; gaba transaminase; gamma-amino-n-butyratetransaminase; (s)-3-amino-2-methylpropionate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (152 aa) |
| | serA | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (521 aa) |
| | dapA2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | ADW21679.1 | Cobalamin biosynthesis aminotransferase. (331 aa) |
| | ADW21690.1 | Cyclase family protein. (269 aa) |
| | ADW21694.1 | Acetylornithine deacetylase. (385 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (387 aa) |
| | puuD | Gamma-glu-gaba hydrolase. (228 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (444 aa) |
| | ADW21799.1 | Ferredoxin-nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (576 aa) |
| | gabT2 | L-aibat; gaba-at; gaba aminotransferase; glutamate:succinic semialdehydetransaminase; gaba transaminase; gamma-amino-n-butyratetransaminase; (s)-3-amino-2-methylpropionate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (447 aa) |
| | gabT3 | 4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa) |
| | metB1 | Homocysteine synthase; OAH sulfhydrylase; O-acetylhomoserinesulfhydrylase. (412 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (422 aa) |
| | metB2 | Homocysteine synthase; OAH sulfhydrylase; O-acetylhomoserinesulfhydrylase. (421 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (380 aa) |
| | ADW21969.1 | Aminotransferase. (372 aa) |
| | ADW22001.1 | Conserved hypothetical protein. (285 aa) |
| | ADW22020.1 | Alternative anthranilate synthase component I+II. (616 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1182 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit. (1035 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (123 aa) |
| | ADW22036.1 | Soluble hydrogenase, small subunit. (352 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (245 aa) |
| | argJ | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (381 aa) |
| | argC2 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (301 aa) |
| | pdxT | Glutamine amidotransferase, subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa) |
| | ADW22202.1 | Aminotransferase, class V. (343 aa) |
| | ADW22286.1 | Conserved hypothetical protein. (346 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (261 aa) |
| | ADW22333.1 | Conserved hypothetical protein. (219 aa) |
| | ADW22393.1 | Zinc-dependent dehydrogenase. (370 aa) |
| | trpA | Tryptophan synthase, subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa) |
| | trpB | Tryptophan synthase, subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa) |
| | pheA | Prephenate dehydratase. (308 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (221 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (503 aa) |
| | ADW22553.1 | methylcrotonoyl-CoA carboxylase beta chain; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; MCCase subunitbeta; 3-methylcrotonyl-CoA carboxylase 2. (560 aa) |
| | ADW22561.1 | Zinc finger, cdgsh-type. (69 aa) |
| | ADW22567.1 | Homoserine dehydrogenase. (332 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (351 aa) |
| | ADW22655.1 | Glutamate synthase, NADPH, large subunit. (1492 aa) |
| | icd2 | Isocitrate dehydrogenase, NADP-dependent; Idp; oxalosuccinatedecarboxylase; idh; nadp(+)-specific icdh. (334 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (549 aa) |
| | trpF | N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (204 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (227 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (463 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (158 aa) |
| | gdhA1 | Glutamate dehydrogenase; GDH; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa) |
| | ald1 | Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (369 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (329 aa) |
| | pabA | Para-aminobenzoate synthase glutamine amidotransferase component II; ADC synthase. (193 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (462 aa) |
| | ADW22868.1 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (516 aa) |
| | ADW22869.1 | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase. (307 aa) |
| | ADW22879.1 | Zinc-binding dehydrogenase. (344 aa) |
| | ald2 | Alanine dehydrogenase; Stage V sporulation protein N. (352 aa) |
| | ADW22913.1 | Thiosulfate sulfurtransferase. (230 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (630 aa) |
| | ADW22971.1 | Carboxypeptidase G2. (371 aa) |
| | ADW22991.1 | Deacetylase. (356 aa) |
| | glmS2 | Glutamine-fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (604 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (423 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (366 aa) |
