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EHB67941.1 EHB67941.1 EHB67942.1 EHB67942.1 ilvC ilvC leuB leuB leuA leuA EHB68411.1 EHB68411.1 EHB65868.1 EHB65868.1 leuA-2 leuA-2 ilvD ilvD leuC leuC leuD leuD EHB63571.1 EHB63571.1 ilvD-2 ilvD-2 EHB43977.1 EHB43977.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Your Input:
EHB67941.1KEGG: gym:GYMC10_5142 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. (580 aa)
EHB67942.1KEGG: gym:GYMC10_5141 acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (161 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
EHB68411.1TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: gym:GYMC10_4593 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa)
EHB65868.1TIGRFAM: branched-chain amino acid aminotransferase; KEGG: gym:GYMC10_6109 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (364 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; KEGG: gym:GYMC10_1610 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (562 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
EHB63571.1PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; KEGG: aoe:Clos_0886 thiamine pyrophosphate protein central region; Belongs to the TPP enzyme family. (541 aa)
ilvD-2TIGRFAM: dihydroxy-acid dehydratase; KEGG: gym:GYMC10_2819 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (562 aa)
EHB43977.1PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: pfo:Pfl01_5358 dihydroxy-acid dehydratase. (171 aa)
Your Current Organism:
Paenibacillus lactis
NCBI taxonomy Id: 743719
Other names: P. lactis 154, Paenibacillus lactis 154, Paenibacillus lactis str. 154, Paenibacillus lactis strain 154
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