STRINGSTRING
ADV25916.1 ADV25916.1 ADV25917.1 ADV25917.1 dut dut pyrE pyrE ADV26129.1 ADV26129.1 ADV26134.1 ADV26134.1 purD purD purH purH gmk gmk thyA thyA ADV26407.1 ADV26407.1 glyA glyA ADV26547.1 ADV26547.1 ADV26644.1 ADV26644.1 surE surE pcm pcm ADV26647.1 ADV26647.1 ADV26648.1 ADV26648.1 purE purE purK purK ADV26698.1 ADV26698.1 purN purN purM purM upp upp ADV27065.1 ADV27065.1 pyrD pyrD ADV27181.1 ADV27181.1 folD folD guaB guaB guaA guaA apt apt carB carB carA carA ADV27622.1 ADV27622.1 tmk tmk pyrB pyrB purT purT purA purA purF purF ADV28095.1 ADV28095.1 ADV28138.1 ADV28138.1 purL purL purC purC ADV28426.1 ADV28426.1 ADV28443.1 ADV28443.1 ADV28445.1 ADV28445.1 adk adk tdk tdk pyrF pyrF ADV28785.1 ADV28785.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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ADV25916.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (814 aa)
ADV25917.1Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (354 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (219 aa)
ADV26129.1Cytosine deaminase; KEGG: xcb:XC_0670 catalytic motif; other site; PFAM: CMP/dCMP deaminase zinc-binding. (158 aa)
ADV26134.1PFAM: PfkB domain protein; KEGG: xcv:XCV0716 putative carbohydrate kinase. (311 aa)
purDTIGRFAM: phosphoribosylamine/glycine ligase; KEGG: xal:XALc_0306 probable phosphoribosylamine--glycine ligase (GarS) (glycinamideribonucleotide synthetase) (phosphoribosylglycinamide synthetase) protein; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (430 aa)
purHSMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: smt:Smal_3662 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (528 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
ADV26407.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
ADV26547.1PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: xcv:XCV3507 inosine-uridine preferring nucleoside hydrolase; Belongs to the IUNH family. (313 aa)
ADV26644.1KEGG: xop:PXO_00166 Smr domain protein; PFAM: Smr protein/MutS2; SMART: Smr protein/MutS2. (183 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (264 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (229 aa)
ADV26647.1KEGG: smt:Smal_1460 hypothetical protein. (204 aa)
ADV26648.1Peptidase M23; KEGG: xop:PXO_00162 lipoprotein; PFAM: Peptidase M23; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding LysM. (278 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (393 aa)
ADV26698.1PFAM: Conserved hypothetical protein CHP00730; KEGG: sml:Smlt1620 putative lysine decarboxylase protein. (460 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (221 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: xal:XALc_2126 putative phosphoribosylaminoimidazole synthetase protein; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (350 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa)
ADV27065.1PFAM: amidohydrolase; KEGG: smt:Smal_2736 dihydroorotase. (450 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (352 aa)
ADV27181.1PFAM: phosphoribosyltransferase; KEGG: xac:XAC1335 hypoxanthine-guanine phosphoribosyltransferase. (195 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (522 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
carBKEGG: xal:XALc_1339 probable carbamoyl-phosphate synthetase large chain protein; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1080 aa)
carAKEGG: xcv:XCV1907 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (398 aa)
ADV27622.1KEGG: xca:xccb100_2781 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain-containing protein; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (223 aa)
pyrBKEGG: xca:xccb100_1415 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (314 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (395 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (489 aa)
ADV28095.1KEGG: xal:XALc_0564 probable FolC bifunctional protein [includes folylpolyglutamate synthase and dihydrofolate synthase]; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein. (424 aa)
ADV28138.1PFAM: glutaredoxin; KEGG: pmy:Pmen_3551 glutaredoxin. (118 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1292 aa)
purCTIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: sml:Smlt4318 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (317 aa)
ADV28426.1Uracil-xanthine permease; KEGG: ctt:CtCNB1_0089 putative pyrimidine permease; TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease. (431 aa)
ADV28443.1KEGG: pap:PSPA7_6297 hypothetical protein. (258 aa)
ADV28445.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (718 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (188 aa)
tdkKEGG: smt:Smal_0047 thymidine kinase; PFAM: thymidine kinase. (206 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (240 aa)
ADV28785.1PFAM: glutamine amidotransferase class-I; KEGG: xca:xccb100_4293 glutamine amidotransferase. (253 aa)
Your Current Organism:
Pseudoxanthomonas suwonensis 111
NCBI taxonomy Id: 743721
Other names: P. suwonensis 11-1, Pseudoxanthomonas suwonensis 11-1, Pseudoxanthomonas suwonensis str. 11-1, Pseudoxanthomonas suwonensis strain 11-1
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