STRINGSTRING
carA carA ADZ76931.1 ADZ76931.1 ADZ77299.1 ADZ77299.1 ADZ77413.1 ADZ77413.1 pyrH pyrH ADZ77691.1 ADZ77691.1 ADZ77716.1 ADZ77716.1 ADZ77816.1 ADZ77816.1 ADZ77930.1 ADZ77930.1 ADZ78028.1 ADZ78028.1 purD purD gmk gmk ADZ78769.1 ADZ78769.1 ADZ78771.1 ADZ78771.1 pyrB pyrB ADZ78786.1 ADZ78786.1 guaA guaA apt apt tdk tdk purH purH purN purN purC purC ADZ79473.1 ADZ79473.1 purA purA pyrE pyrE purE purE purK purK ADZ79780.1 ADZ79780.1 surE surE ADZ79948.1 ADZ79948.1 folD folD pyrD pyrD ADZ80084.1 ADZ80084.1 ADZ80158.1 ADZ80158.1 guaB guaB purL purL ADZ80420.1 ADZ80420.1 ADZ80518.1 ADZ80518.1 pyrF pyrF ADZ81175.1 ADZ81175.1 purA-2 purA-2 ADZ81625.1 ADZ81625.1 surE-2 surE-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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textmining
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carATIGRFAM: Carbamoyl-phosphate synthase, small subunit; KEGG: phe:Phep_0705 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (366 aa)
ADZ76931.1Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
ADZ77299.1PFAM: Phosphoribosyltransferase; KEGG: phe:Phep_4038 uracil phosphoribosyltransferase. (214 aa)
ADZ77413.1PFAM: Inosine/uridine-preferring nucleoside hydrolase domain; KEGG: dfe:Dfer_4323 inosine/uridine-preferring nucleoside hydrolase. (331 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa)
ADZ77691.1TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: phe:Phep_0124 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation. (938 aa)
ADZ77716.1PFAM: Phosphoribosyltransferase; KEGG: phe:Phep_3621 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase. (171 aa)
ADZ77816.1TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase; KEGG: phe:Phep_2365 deoxyguanosinetriphosphate triphosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD domain. (448 aa)
ADZ77930.1TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: phe:Phep_0044 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa)
ADZ78028.1Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa)
purDPhosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: phe:Phep_0267 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (426 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (188 aa)
ADZ78769.1KEGG: rbi:RB2501_07515 amidophosphoribosyltransferase; PFAM: Glutamine amidotransferase, class-II. (636 aa)
ADZ78771.1PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: phe:Phep_0992 CMP/dCMP deaminase zinc-binding. (149 aa)
pyrBPFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase, eukaryotic; KEGG: phe:Phep_1173 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa)
ADZ78786.1KEGG: phe:Phep_1174 uracil phosphoribosyltransferase; PFAM: Phosphoribosyltransferase. (183 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (516 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa)
tdkHAMAP: Thymidine kinase, subgroup; KEGG: phe:Phep_0802 thymidine kinase; PFAM: Thymidine kinase. (193 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: phe:Phep_0809 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain. (508 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa)
purCHAMAP: SAICAR synthetase; KEGG: phe:Phep_1864 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (318 aa)
ADZ79473.1KEGG: phe:Phep_3079 AMP nucleosidase; TIGRFAM: AMP nucleosidase, putative; PFAM: Nucleoside phosphorylase domain. (272 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
ADZ79780.1Guanine deaminase; KEGG: sli:Slin_2805 CMP/dCMP deaminase zinc-binding protein; PFAM: CMP/dCMP deaminase, zinc-binding. (160 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa)
ADZ79948.1KEGG: phe:Phep_3862 5 nucleotidase deoxy cytosolic type C. (188 aa)
folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (345 aa)
ADZ80084.1MazG family protein; KEGG: phe:Phep_1231 nucleoside triphosphate pyrophosphohydrolase; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core. (267 aa)
ADZ80158.1TIGRFAM: Adenylosuccinate lyase; KEGG: phe:Phep_2933 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal/plant; Lyase 1, N-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (445 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1219 aa)
ADZ80420.1Allantoinase; KEGG: phe:Phep_3229 dihydroorotase; PFAM: Amidohydrolase 1. (445 aa)
ADZ80518.1KEGG: cpi:Cpin_6522 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal. (391 aa)
pyrFKEGG: lby:Lbys_3332 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase domain; TIGRFAM: Orotidine 5'-phosphate decarboxylase, type 2; HAMAP: Orotidine 5'-phosphate decarboxylase, type 2; SMART: Orotidine 5'-phosphate decarboxylase domain; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa)
ADZ81175.1KEGG: phe:Phep_2916 uridine kinase; PFAM: Phosphoribulokinase/uridine kinase. (210 aa)
purA-2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
ADZ81625.1KEGG: phe:Phep_3185 dihydroorotase, multifunctional complex type; TIGRFAM: Dihydroorotase; PFAM: Amidohydrolase 1. (423 aa)
surE-2Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
Your Current Organism:
Sphingobacterium sp. 21
NCBI taxonomy Id: 743722
Other names: S. sp. 21
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