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ADZ77930.1 ADZ77930.1 ADZ78028.1 ADZ78028.1 gmk gmk guaA guaA apt apt purA purA ADZ80084.1 ADZ80084.1 guaB guaB purA-2 purA-2 surE-2 surE-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ADZ77930.1TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: phe:Phep_0044 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa)
ADZ78028.1Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (188 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (516 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa)
ADZ80084.1MazG family protein; KEGG: phe:Phep_1231 nucleoside triphosphate pyrophosphohydrolase; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core. (267 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
purA-2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
surE-2Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
Your Current Organism:
Sphingobacterium sp. 21
NCBI taxonomy Id: 743722
Other names: S. sp. 21
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