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dapA dapA ADZ76961.1 ADZ76961.1 ADZ76963.1 ADZ76963.1 dapB dapB metZ metZ ADZ77281.1 ADZ77281.1 ADZ77320.1 ADZ77320.1 ADZ77603.1 ADZ77603.1 ADZ77604.1 ADZ77604.1 argC argC ADZ77607.1 ADZ77607.1 ADZ77608.1 ADZ77608.1 argB argB ADZ77611.1 ADZ77611.1 argH argH asd asd dapF dapF ADZ77902.1 ADZ77902.1 ADZ77991.1 ADZ77991.1 thrB thrB ADZ77993.1 ADZ77993.1 cysS cysS ADZ78068.1 ADZ78068.1 ADZ78069.1 ADZ78069.1 trpC trpC metK metK ADZ78168.1 ADZ78168.1 ADZ78476.1 ADZ78476.1 ADZ78544.1 ADZ78544.1 ADZ78590.1 ADZ78590.1 ADZ78830.1 ADZ78830.1 ilvA ilvA leuB leuB ADZ78834.1 ADZ78834.1 ADZ78835.1 ADZ78835.1 leuC leuC leuA leuA ADZ78838.1 ADZ78838.1 ilvC ilvC ADZ78840.1 ADZ78840.1 ADZ78841.1 ADZ78841.1 ADZ78843.1 ADZ78843.1 ilvD ilvD ADZ78854.1 ADZ78854.1 ADZ78982.1 ADZ78982.1 ADZ79474.1 ADZ79474.1 ADZ79538.1 ADZ79538.1 ADZ79582.1 ADZ79582.1 trpD trpD trpF trpF trpB trpB trpA trpA aroQ aroQ ADZ79714.1 ADZ79714.1 lysA lysA aroC aroC aroA aroA ADZ79764.1 ADZ79764.1 ADZ79919.1 ADZ79919.1 metXA metXA ADZ79921.1 ADZ79921.1 ADZ80087.1 ADZ80087.1 ADZ80454.1 ADZ80454.1 ADZ80542.1 ADZ80542.1 ADZ80659.1 ADZ80659.1 ADZ80660.1 ADZ80660.1 ADZ81103.1 ADZ81103.1 ADZ81148.1 ADZ81148.1 ADZ81160.1 ADZ81160.1 ADZ81185.1 ADZ81185.1 hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI aroK aroK metE metE
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa)
ADZ76961.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa)
ADZ76963.1KEGG: phe:Phep_3800 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (246 aa)
metZCystathionine gamma-lyase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (389 aa)
ADZ77281.1KEGG: phe:Phep_0239 L-serine dehydratase 1; TIGRFAM: Iron-sulphur-dependent L-serine dehydratase single chain form; PFAM: Serine dehydratase-like, alpha subunit; Serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (475 aa)
ADZ77320.1TIGRFAM: Branched-chain amino acid aminotransferase II; KEGG: phe:Phep_0259 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV. (384 aa)
ADZ77603.1KEGG: phe:Phep_4210 hypothetical protein. (231 aa)
ADZ77604.1TIGRFAM: Argininosuccinate synthase; KEGG: phe:Phep_4209 argininosuccinate synthase; PFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
ADZ77607.1Acetylornithine transaminase; KEGG: phe:Phep_4207 aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (379 aa)
ADZ77608.1KEGG: phe:Phep_4206 N-acetylornithine carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (332 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (281 aa)
ADZ77611.1PFAM: Peptidase M20; Peptidase M20, dimerisation; KEGG: phe:Phep_4203 peptidase M20. (355 aa)
argHPFAM: Lyase 1, N-terminal; TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: phe:Phep_4202 argininosuccinate lyase. (443 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (263 aa)
ADZ77902.1KEGG: cpi:Cpin_1671 shikimate dehydrogenase substrate binding domain protein; PFAM: Shikimate dehydrogenase substrate binding, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase. (259 aa)
ADZ77991.1TIGRFAM: Threonine synthase; KEGG: phe:Phep_3802 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (437 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (325 aa)
ADZ77993.1TIGRFAM: Aspartate kinase domain; KEGG: phe:Phep_3804 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding. (815 aa)
cysSSMART: Cysteinyl-tRNA synthetase, class Ia, DALR; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: phe:Phep_0485 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; Belongs to the class-I aminoacyl-tRNA synthetase family. (487 aa)
ADZ78068.1KEGG: phe:Phep_4170 anthranilate synthase; PFAM: Chorismate binding, C-terminal; Anthranilate synthase component I, N-terminal. (469 aa)
ADZ78069.1TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; KEGG: phe:Phep_4169 glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal. (197 aa)
trpCKEGG: phe:Phep_4168 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (417 aa)
ADZ78168.1KEGG: cpi:Cpin_1938 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (386 aa)
ADZ78476.1PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: gfo:GFO_0761 Cys/Met metabolism pyridoxal-phosphate-dependent enzyme. (381 aa)
ADZ78544.1Hypothetical protein; KEGG: sli:Slin_4776 pyridoxal-5'-phosphate-dependent protein beta subunit. (224 aa)
ADZ78590.1PFAM: Bacterial transferase hexapeptide repeat; KEGG: dge:Dgeo_0348 serine O-acetyltransferase. (183 aa)
ADZ78830.13-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (412 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa)
ADZ78834.1(R)-citramalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; KEGG: phe:Phep_3427 pyruvate carboxyltransferase; SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (504 aa)
ADZ78835.13-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (464 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (503 aa)
ADZ78838.1KEGG: phe:Phep_3423 ABC transporter related; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core. (487 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa)
ADZ78840.1KEGG: phe:Phep_3421 hypothetical protein. (163 aa)
ADZ78841.1KEGG: phe:Phep_3420 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Amino acid-binding ACT; Acetolactate synthase, small subunit, C-terminal. (196 aa)
ADZ78843.1TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: phe:Phep_3419 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (583 aa)
ilvDPFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: phe:Phep_3418 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (564 aa)
ADZ78854.1PFAM: Dihydrodipicolinate synthetase; KEGG: phe:Phep_2814 dihydrodipicolinate synthetase; Belongs to the DapA family. (313 aa)
ADZ78982.1KEGG: phe:Phep_0858 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (272 aa)
ADZ79474.1Cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cystathionine beta-synthase, core; KEGG: phe:Phep_1434 cysteine synthase; SMART: Cystathionine beta-synthase, core. (454 aa)
ADZ79538.1Aminodeoxychorismate synthase; KEGG: phe:Phep_1201 chorismate binding; PFAM: Chorismate binding, C-terminal. (427 aa)
ADZ79582.1KEGG: ddi:DDB_G0271136 GAF domain-containing protein. (157 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa)
trpFKEGG: phe:Phep_3025 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (207 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa)
ADZ79714.1TIGRFAM: Aspartate kinase domain; KEGG: phe:Phep_2333 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (438 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (392 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (415 aa)
ADZ79764.13-deoxy-7-phosphoheptulonate synthase; PFAM: Chorismate mutase, type II; DAHP synthetase I/KDSA; KEGG: phe:Phep_1512 DAHP synthetase I/KdsA; SMART: Chorismate mutase. (368 aa)
ADZ79919.1TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: phe:Phep_1875 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (463 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (352 aa)
ADZ79921.1KEGG: phe:Phep_1873 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding. (393 aa)
ADZ80087.1Aminodeoxychorismate lyase; KEGG: phe:Phep_1220 aminotransferase class IV; PFAM: Aminotransferase, class IV. (288 aa)
ADZ80454.1Acetylornithine transaminase; KEGG: phe:Phep_0869 aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
ADZ80542.1PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; KEGG: phe:Phep_1400 Glu/Leu/Phe/Val dehydrogenase dimerisation region; SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (360 aa)
ADZ80659.1TIGRFAM: Cysteine synthase B; Cysteine synthase K/M; KEGG: phe:Phep_2362 cysteine synthase B; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (289 aa)
ADZ80660.1KEGG: phe:Phep_2363 serine O-acetyltransferase. (278 aa)
ADZ81103.1PFAM: Dihydrodipicolinate synthetase; KEGG: phe:Phep_2224 dihydrodipicolinate synthetase; Belongs to the DapA family. (320 aa)
ADZ81148.1Cysteine synthase; KEGG: phe:Phep_1609 pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (359 aa)
ADZ81160.1KEGG: phe:Phep_2908 cystathionine gamma-lyase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (379 aa)
ADZ81185.1TIGRFAM: Aspartate kinase domain; KEGG: phe:Phep_2925 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (422 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
hisCPFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: cpi:Cpin_1819 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (354 aa)
hisBPFAM: Imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: phe:Phep_3194 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (381 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisAHAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: phe:Phep_3196 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imid azole-4-carboxamideisomerase; PFAM: Histidine biosynthesis. (249 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (262 aa)
hisIPFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: phe:Phep_3198 phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (195 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (773 aa)
Your Current Organism:
Sphingobacterium sp. 21
NCBI taxonomy Id: 743722
Other names: S. sp. 21
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